Adenosine in Peripheral Chemoreception: New Insights into a Historically Overlooked Molecule - Invited Article

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Abstract

In the present article we review in a concise manner the literature on the general biology of adenosine signalling. In the first section we describe briefly the historical aspects of adenosine research. In the second section is presented the biochemical characteristics of this nucleoside, namely its metabolism and regulation, and its physiological actions. In the third section we have succinctly described the role of adenosine and its metabolism in hypoxia. The final section is devoted to the role of adenosine in chemoreception in the carotid body, providing a review of the literature on the presence of adenosine receptors in the carotid body; on the effects of adenosine at presynaptic level in carotid body chemoreceptor cells, as well as, its metabolism and regulation; and at postsynaptic level in carotid sinus nerve activity. Additionally, a review on the effects of adenosine in ventilation was done. This review discusses evidence for a key role of adenosine in the hypoxic response of carotid body and emphasizes new research likely to be important in the future.
Original languageEnglish
Title of host publicationAdvances in Experimental Medicine and Biology
EditorsC Gonzalez, CA Nurse, C Peers
Place of PublicationBerlin
PublisherSPRINGER-VERLAG BERLIN
Pages145-159
Volume648
ISBN (Print)978-90-481-2258-5
DOIs
Publication statusPublished - 2009
Event17th Meeting of the International-Society-for-Arterial-Chemoreception (ISAC) Location: Valladolid, SPAIN -
Duration: 1 Jan 2008 → …

Conference

Conference17th Meeting of the International-Society-for-Arterial-Chemoreception (ISAC) Location: Valladolid, SPAIN
Period1/01/08 → …

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    Conde, S., & Monteiro, E. C. (2009). Adenosine in Peripheral Chemoreception: New Insights into a Historically Overlooked Molecule - Invited Article. In C. Gonzalez, CA. Nurse, & C. Peers (Eds.), Advances in Experimental Medicine and Biology (Vol. 648, pp. 145-159). Berlin: SPRINGER-VERLAG BERLIN. https://doi.org/10.1007/978-90-481-2259-2_17