Acute lymphoblastic leukemia presenting with bilateral serous macular detachment

L. Vieira, N.A. Silva, M.D. Medeiros, R. Flores, V. Maduro

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6 Citations (Scopus)


Acute lymphoblastic leukemia is a malignant hematopoietic neoplasia, which is rare in adults. Although ocular fundus alterations may be commonly observed in the course of the disease, such alterations are rarely the presenting signs of the disease. Here we describe the case of a patient with painless and progressiveloss of visual acuity (right eye, 2/10; left eye, 3/10) developing over two weeks, accompanied by fever and cervical lymphadenopathy. Fundus examination showed bilateral macular serous detachment, which was confirmed by optical coherence tomography. Fluorescein angiography revealed hyperfluorescent pinpoints in the posterior poles. The limits of the macular detachment were revealed in the late phase of the angiogram. The results of blood count analysis triggered a thorough, systematic patient examination. The diagnosis of acute lymphoblastic leukemia B (CD10+) was established, and intensive systemic chemotherapy was immediately initiated. One year after the diagnosis, the patient remains in complete remission without any ophthalmologic alterations.
Original languageEnglish
Pages (from-to)382-384
Number of pages3
JournalArquivos Brasileiros de Oftalmologia
Issue number6
Publication statusPublished - 2015


  • Acute lymphoblastic leukemia
  • Fluorescein angiography
  • Optical coherence tomography
  • Serous macular detachment
  • Visual acuity
  • case report
  • complication
  • female
  • fluorescence angiography
  • human
  • middle aged
  • optical coherence tomography
  • pathology
  • Precursor Cell Lymphoblastic Leukemia-Lymphoma
  • retina macula lutea
  • Retinal Detachment
  • treatment outcome
  • visual acuity
  • Female
  • Fluorescein Angiography
  • Humans
  • Macula Lutea
  • Middle Aged
  • Tomography, Optical Coherence
  • Treatment Outcome
  • Visual Acuity


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