Acute liver failure due to radiographically occult infiltration of urothelial cancer

Valentina Tosatto; João Cabral Pimentel; Cristiano Cruz; André Almeida; Matteo Boattini

doi:10.4322/acr.2021.256

Acute liver failure due to radiographically occult infiltration of urothelial cancer

Valentina Tosatto, João Cabral Pimentel, Cristiano Cruz, André Almeida, Matteo Boattini

NOVA Medical School|Faculdade de Ciências Médicas (NMS|FCM)

Research output: Contribution to journal › Article › peer-review

25 Downloads (Pure)

Abstract

Introduction: Acute liver failure (ALF) due to diffuse infiltrating solid malignancy without any focal lesions on radiographic imaging is rare. Case report: A 70-year-old man was admitted due to mental confusion, abdominal pain, and ALF. Three years before, he had undergone a left nephrectomy for urothelial carcinoma followed by adjuvant chemotherapy. The abdominal computed tomography (CT) showed hepatomegaly and ascites. Ascitic fluid had transudate characteristics, with no malignant cells. Percutaneous liver biopsy (LB) showed diffuse liver infiltration of metastatic urothelial carcinoma. The patient rapidly deteriorated and died in a week due to ALF. Discussion: History of solid cancer and hepatomegaly and/or liver failure without other obvious explanation should encourage to perform LB. Conclusion: LB is warranted to avoid misdiagnosis, prolonged hospital stays, and delay in palliative care.

Original language	English
Article number	e2021256
Journal	Autopsy and Case Reports
Volume	11
DOIs	https://doi.org/10.4322/acr.2021.256
Publication status	Published - 2021

Keywords

Biopsy
Neoplasms
Palliative care

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

Access to Document

10.4322/acr.2021.256Licence: CC BY

autopsy-11-e2021256Final published version, 635 KBLicence: CC BY

Cite this

@article{01797d56d09141829fbd3c46c84c269c,

title = "Acute liver failure due to radiographically occult infiltration of urothelial cancer",

abstract = "Introduction: Acute liver failure (ALF) due to diffuse infiltrating solid malignancy without any focal lesions on radiographic imaging is rare. Case report: A 70-year-old man was admitted due to mental confusion, abdominal pain, and ALF. Three years before, he had undergone a left nephrectomy for urothelial carcinoma followed by adjuvant chemotherapy. The abdominal computed tomography (CT) showed hepatomegaly and ascites. Ascitic fluid had transudate characteristics, with no malignant cells. Percutaneous liver biopsy (LB) showed diffuse liver infiltration of metastatic urothelial carcinoma. The patient rapidly deteriorated and died in a week due to ALF. Discussion: History of solid cancer and hepatomegaly and/or liver failure without other obvious explanation should encourage to perform LB. Conclusion: LB is warranted to avoid misdiagnosis, prolonged hospital stays, and delay in palliative care.",

keywords = "Biopsy, Neoplasms, Palliative care",

author = "Valentina Tosatto and Pimentel, {Jo{\~a}o Cabral} and Cristiano Cruz and Andr{\'e} Almeida and Matteo Boattini",

year = "2021",

doi = "10.4322/acr.2021.256",

language = "English",

volume = "11",

journal = "Autopsy and Case Reports",

issn = "2236-1960",

publisher = "Hospital Universitario da Universidade de Sao Paulo",

}

TY - JOUR

T1 - Acute liver failure due to radiographically occult infiltration of urothelial cancer

AU - Tosatto, Valentina

AU - Pimentel, João Cabral

AU - Cruz, Cristiano

AU - Almeida, André

AU - Boattini, Matteo

PY - 2021

Y1 - 2021

N2 - Introduction: Acute liver failure (ALF) due to diffuse infiltrating solid malignancy without any focal lesions on radiographic imaging is rare. Case report: A 70-year-old man was admitted due to mental confusion, abdominal pain, and ALF. Three years before, he had undergone a left nephrectomy for urothelial carcinoma followed by adjuvant chemotherapy. The abdominal computed tomography (CT) showed hepatomegaly and ascites. Ascitic fluid had transudate characteristics, with no malignant cells. Percutaneous liver biopsy (LB) showed diffuse liver infiltration of metastatic urothelial carcinoma. The patient rapidly deteriorated and died in a week due to ALF. Discussion: History of solid cancer and hepatomegaly and/or liver failure without other obvious explanation should encourage to perform LB. Conclusion: LB is warranted to avoid misdiagnosis, prolonged hospital stays, and delay in palliative care.

AB - Introduction: Acute liver failure (ALF) due to diffuse infiltrating solid malignancy without any focal lesions on radiographic imaging is rare. Case report: A 70-year-old man was admitted due to mental confusion, abdominal pain, and ALF. Three years before, he had undergone a left nephrectomy for urothelial carcinoma followed by adjuvant chemotherapy. The abdominal computed tomography (CT) showed hepatomegaly and ascites. Ascitic fluid had transudate characteristics, with no malignant cells. Percutaneous liver biopsy (LB) showed diffuse liver infiltration of metastatic urothelial carcinoma. The patient rapidly deteriorated and died in a week due to ALF. Discussion: History of solid cancer and hepatomegaly and/or liver failure without other obvious explanation should encourage to perform LB. Conclusion: LB is warranted to avoid misdiagnosis, prolonged hospital stays, and delay in palliative care.

KW - Biopsy

KW - Neoplasms

KW - Palliative care

UR - http://www.scopus.com/inward/record.url?scp=85104879935&partnerID=8YFLogxK

U2 - 10.4322/acr.2021.256

DO - 10.4322/acr.2021.256

M3 - Article

AN - SCOPUS:85104879935

SN - 2236-1960

VL - 11

JO - Autopsy and Case Reports

JF - Autopsy and Case Reports

M1 - e2021256

ER -

Acute liver failure due to radiographically occult infiltration of urothelial cancer

Abstract

Keywords

UN SDGs

Access to Document

Other files and links

Fingerprint

Cite this