Acute Aquatic Toxicity and Biodegradability of Fluorinated Ionic Liquids

Research output: Contribution to journalArticle

3 Citations (Scopus)

Abstract

Several novel fluorinated ionic liquids (FILs), fully miscible with water and with excellent surfactant behavior, have been studied for pharmacological applications. The use of these novel FILs as drug delivery systems can improve the bioavailability, stability and efficacy of therapeutic proteins. An initial screening of toxicity in four different human cell lines indicated that some of the FILs possess low cytotoxicity. An environmental hazard assessment of these compounds, in the context of Green Pharmacy, is necessary before a pharmaceutical application takes place. In this work, ecotoxicity tests have been performed in aquatic species with different levels of biological organization (Vibrio fischeri, Daphnia magna and Lemna minor) to evaluate intrinsic hazard that these FILs might pose after being released to the aquatic environment from the human body or from industrial processes. Additionally, the biodegradability of these compounds has been evaluated using microorganisms from wastewater treatment plants. ©

Original languageEnglish
Pages (from-to)3733-3741
Number of pages9
JournalACS Sustainable Chemistry and Engineering
Volume7
Issue number4
DOIs
Publication statusPublished - 18 Feb 2019

Fingerprint

Ionic Liquids
Biodegradability
Ionic liquids
Toxicity
toxicity
Hazards
drug
environmental hazard
Cytotoxicity
hazard assessment
Surface-Active Agents
Wastewater treatment
Microorganisms
Drug products
aquatic environment
bioavailability
surfactant
Screening
Surface active agents
microorganism

Keywords

  • Aquatic environment
  • Biodegradation
  • Daphnia magna
  • Ecotoxicity
  • Fluorosurfactants
  • Lemna minor
  • Pharmaceuticals
  • Vibrio fischeri

Cite this

@article{b538102e850840ed9e5eed8ce41d104d,
title = "Acute Aquatic Toxicity and Biodegradability of Fluorinated Ionic Liquids",
abstract = "Several novel fluorinated ionic liquids (FILs), fully miscible with water and with excellent surfactant behavior, have been studied for pharmacological applications. The use of these novel FILs as drug delivery systems can improve the bioavailability, stability and efficacy of therapeutic proteins. An initial screening of toxicity in four different human cell lines indicated that some of the FILs possess low cytotoxicity. An environmental hazard assessment of these compounds, in the context of Green Pharmacy, is necessary before a pharmaceutical application takes place. In this work, ecotoxicity tests have been performed in aquatic species with different levels of biological organization (Vibrio fischeri, Daphnia magna and Lemna minor) to evaluate intrinsic hazard that these FILs might pose after being released to the aquatic environment from the human body or from industrial processes. Additionally, the biodegradability of these compounds has been evaluated using microorganisms from wastewater treatment plants. {\circledC}",
keywords = "Aquatic environment, Biodegradation, Daphnia magna, Ecotoxicity, Fluorosurfactants, Lemna minor, Pharmaceuticals, Vibrio fischeri",
author = "Vieira, {Nicole S. M.} and Stefan Stolte and Ara{\'u}jo, {Jo{\~a}o M. M.} and Rebelo, {Lu{\'i}s Paulo N.} and Pereiro, {Ana B.} and Marta Markiewicz",
note = "The authors thank the financial support from FCT/MCTES (Portugal), through grant SFRH/BD/100563/2014 (N.S.M.V.) and {"}Investigador FCT 2014{"} (IF/00190/2014 to A.B.P and IF/00210/2014 to J.M.M.A.), and projects PTDC/EQU-EQU/29737/2017, PTDC/QEQ-FTT/3289/2014, IF/00210/2014/CP1244/CT0003. This work was supported by the Associate Laboratory for Green Chemistry - LAQV which is financed by national funds from FCT/MCTES (UID/QUI/50006/2019). Financial support was also obtained through the STSM-CM1206-151216-081721 COST Action. The authors also acknowledge the financial support of the University of Bremen and the European Union FP7 COFUND within Marie Curie Actions BremenTrac Program (grant agreement No.600411) and the {"}M8 Postdoc-Initiative PLUS{"}, funded by the German Excellence Initiative.",
year = "2019",
month = "2",
day = "18",
doi = "10.1021/acssuschemeng.8b03653",
language = "English",
volume = "7",
pages = "3733--3741",
journal = "ACS SUSTAINABLE CHEMISTRY & ENGINEERING",
issn = "2168-0485",
publisher = "AMER CHEMICAL SOC",
number = "4",

}

Acute Aquatic Toxicity and Biodegradability of Fluorinated Ionic Liquids. / Vieira, Nicole S. M.; Stolte, Stefan; Araújo, João M. M.; Rebelo, Luís Paulo N.; Pereiro, Ana B.; Markiewicz, Marta.

In: ACS Sustainable Chemistry and Engineering, Vol. 7, No. 4, 18.02.2019, p. 3733-3741.

Research output: Contribution to journalArticle

TY - JOUR

T1 - Acute Aquatic Toxicity and Biodegradability of Fluorinated Ionic Liquids

AU - Vieira, Nicole S. M.

AU - Stolte, Stefan

AU - Araújo, João M. M.

AU - Rebelo, Luís Paulo N.

AU - Pereiro, Ana B.

AU - Markiewicz, Marta

N1 - The authors thank the financial support from FCT/MCTES (Portugal), through grant SFRH/BD/100563/2014 (N.S.M.V.) and "Investigador FCT 2014" (IF/00190/2014 to A.B.P and IF/00210/2014 to J.M.M.A.), and projects PTDC/EQU-EQU/29737/2017, PTDC/QEQ-FTT/3289/2014, IF/00210/2014/CP1244/CT0003. This work was supported by the Associate Laboratory for Green Chemistry - LAQV which is financed by national funds from FCT/MCTES (UID/QUI/50006/2019). Financial support was also obtained through the STSM-CM1206-151216-081721 COST Action. The authors also acknowledge the financial support of the University of Bremen and the European Union FP7 COFUND within Marie Curie Actions BremenTrac Program (grant agreement No.600411) and the "M8 Postdoc-Initiative PLUS", funded by the German Excellence Initiative.

PY - 2019/2/18

Y1 - 2019/2/18

N2 - Several novel fluorinated ionic liquids (FILs), fully miscible with water and with excellent surfactant behavior, have been studied for pharmacological applications. The use of these novel FILs as drug delivery systems can improve the bioavailability, stability and efficacy of therapeutic proteins. An initial screening of toxicity in four different human cell lines indicated that some of the FILs possess low cytotoxicity. An environmental hazard assessment of these compounds, in the context of Green Pharmacy, is necessary before a pharmaceutical application takes place. In this work, ecotoxicity tests have been performed in aquatic species with different levels of biological organization (Vibrio fischeri, Daphnia magna and Lemna minor) to evaluate intrinsic hazard that these FILs might pose after being released to the aquatic environment from the human body or from industrial processes. Additionally, the biodegradability of these compounds has been evaluated using microorganisms from wastewater treatment plants. ©

AB - Several novel fluorinated ionic liquids (FILs), fully miscible with water and with excellent surfactant behavior, have been studied for pharmacological applications. The use of these novel FILs as drug delivery systems can improve the bioavailability, stability and efficacy of therapeutic proteins. An initial screening of toxicity in four different human cell lines indicated that some of the FILs possess low cytotoxicity. An environmental hazard assessment of these compounds, in the context of Green Pharmacy, is necessary before a pharmaceutical application takes place. In this work, ecotoxicity tests have been performed in aquatic species with different levels of biological organization (Vibrio fischeri, Daphnia magna and Lemna minor) to evaluate intrinsic hazard that these FILs might pose after being released to the aquatic environment from the human body or from industrial processes. Additionally, the biodegradability of these compounds has been evaluated using microorganisms from wastewater treatment plants. ©

KW - Aquatic environment

KW - Biodegradation

KW - Daphnia magna

KW - Ecotoxicity

KW - Fluorosurfactants

KW - Lemna minor

KW - Pharmaceuticals

KW - Vibrio fischeri

UR - http://www.scopus.com/inward/record.url?scp=85062055757&partnerID=8YFLogxK

U2 - 10.1021/acssuschemeng.8b03653

DO - 10.1021/acssuschemeng.8b03653

M3 - Article

VL - 7

SP - 3733

EP - 3741

JO - ACS SUSTAINABLE CHEMISTRY & ENGINEERING

JF - ACS SUSTAINABLE CHEMISTRY & ENGINEERING

SN - 2168-0485

IS - 4

ER -