Acidic porous carbons involved in the green and selective synthesis of benzodiazepines

M. Godino-Ojer, I. Matos, M. Bernardo, R. Carvalho, Olivia Salomé Soares, C. Durán-Valle, I. M. Fonseca, E. Pérez Mayoral

Research output: Contribution to journalArticle

Abstract

Eco-sustainable and recyclable porous carbons are reported as metal-free catalysts for the synthesis of benzodiazepines for the first time. The porous carbons were able to efficiently catalyse the synthesis of benzodiazepine 1 from o-phenylendiamine 2 and acetone 3 under mild conditions. Both acidic functions and the porosity of the catalysts were determinant features. High conversion values were obtained when using HNO3 oxidized carbons. The highest selectivity to benzodiazepine 1 was obtained in the presence of the most microporous catalyst N-N, which is indicative of the great influence of porous properties. Stronger acid sites and high microporosity of the carbon treated with H2SO4 yield benzodiazepine 1 with total selectivity.

Original languageEnglish
JournalCatalysis Today
DOIs
Publication statusAccepted/In press - 1 Jan 2019

Keywords

  • Activated carbons
  • Benzodiazepines
  • Heterocyclic chemistry
  • Heterogeneous catalytic systems

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