Acemetacin and indomethacin detection using modified carbon microelectrodes

Lénia M. Calado; Cristina M. Cordas; João P. Sousa

Acemetacin and indomethacin detection using modified carbon microelectrodes

Lénia M. Calado, Cristina M. Cordas, João P. Sousa

Research output: Contribution to journal › Article › peer-review

Abstract

In the present work, mercury thin film modified carbon microelectrodes were tested towards detection of the pharmacological compounds acemetacin and indomethacin. The compounds were characterized electrochemically by adsorptive stripping differential pulse and square wave voltammetry (AdSDPV and AdSSWV). Best results were obtained via AdSDPV for both compounds (Acemetacin: LOD=1.05×10^-7 M, LOQ=3.51× 10^-7 M; Indomethacin: LOD=1.34× 10^-7 M, LOQ=4.47× 10^-7 M). These results are comparable to earlier reports using classical hanging drop mercury electrodes, but with environmental advantages due to the limited mercury amount that is used and the easy way to recover it. Detection and quantification limits are lower than the obtained with currently used analytical techniques.

Original language	English
Pages (from-to)	665-671
Number of pages	7
Journal	Analytical and Bioanalytical Electrochemistry
Volume	5
Issue number	6
Publication status	Published - Oct 2013

Keywords

Acemetacin
Electroanalytical techniques
Indomethacin
Microelectrodes
Thin mercury film

Cite this

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title = "Acemetacin and indomethacin detection using modified carbon microelectrodes",

abstract = "In the present work, mercury thin film modified carbon microelectrodes were tested towards detection of the pharmacological compounds acemetacin and indomethacin. The compounds were characterized electrochemically by adsorptive stripping differential pulse and square wave voltammetry (AdSDPV and AdSSWV). Best results were obtained via AdSDPV for both compounds (Acemetacin: LOD=1.05×10-7 M, LOQ=3.51× 10-7 M; Indomethacin: LOD=1.34× 10-7 M, LOQ=4.47× 10-7 M). These results are comparable to earlier reports using classical hanging drop mercury electrodes, but with environmental advantages due to the limited mercury amount that is used and the easy way to recover it. Detection and quantification limits are lower than the obtained with currently used analytical techniques.",

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AU - Calado, Lénia M.

AU - Cordas, Cristina M.

AU - Sousa, João P.

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N2 - In the present work, mercury thin film modified carbon microelectrodes were tested towards detection of the pharmacological compounds acemetacin and indomethacin. The compounds were characterized electrochemically by adsorptive stripping differential pulse and square wave voltammetry (AdSDPV and AdSSWV). Best results were obtained via AdSDPV for both compounds (Acemetacin: LOD=1.05×10-7 M, LOQ=3.51× 10-7 M; Indomethacin: LOD=1.34× 10-7 M, LOQ=4.47× 10-7 M). These results are comparable to earlier reports using classical hanging drop mercury electrodes, but with environmental advantages due to the limited mercury amount that is used and the easy way to recover it. Detection and quantification limits are lower than the obtained with currently used analytical techniques.

AB - In the present work, mercury thin film modified carbon microelectrodes were tested towards detection of the pharmacological compounds acemetacin and indomethacin. The compounds were characterized electrochemically by adsorptive stripping differential pulse and square wave voltammetry (AdSDPV and AdSSWV). Best results were obtained via AdSDPV for both compounds (Acemetacin: LOD=1.05×10-7 M, LOQ=3.51× 10-7 M; Indomethacin: LOD=1.34× 10-7 M, LOQ=4.47× 10-7 M). These results are comparable to earlier reports using classical hanging drop mercury electrodes, but with environmental advantages due to the limited mercury amount that is used and the easy way to recover it. Detection and quantification limits are lower than the obtained with currently used analytical techniques.

KW - Acemetacin

KW - Electroanalytical techniques

KW - Indomethacin

KW - Microelectrodes

KW - Thin mercury film

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JF - Analytical and Bioanalytical Electrochemistry

IS - 6

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Acemetacin and indomethacin detection using modified carbon microelectrodes

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