TY - JOUR
T1 - Ability of Antibiotic-Resistant Nonvaccine-Type Pneumococcal Clones to Cause Otitis Media in an Infant Mouse Model of Pneumococcal-Influenza Virus Coinfection
AU - Frazão, Nelson
AU - Hermans, Peter W M
AU - Van Selm, Saskia
AU - Sá-Leão, Raquel
AU - De Lencastre, Hermínia
AU - Tomasz, Alexander
AU - Diavatopoulos, Dimitri
PY - 2016/1/1
Y1 - 2016/1/1
N2 - The introduction of the 7-valent pneumococcal conjugate vaccine in Portugal resulted in reduced carriage in children by vaccine-type strains and an increased carriage of three major antibiotic-resistant clones, ST2191, ST276, and ST63 expressing capsules 6A, 19A, and 15A, respectively. Pneumococcal otitis media (OM), a frequent infection among preschool age children, is often associated with viral coinfection. To evaluate the ability of these three antibiotic-resistant clones to cause disease, we used an infant mouse model of influenza virus pneumococcal coinfection. The 6A and 19A clonal types induced OM, while 15A induced pneumococcal pneumonia and bloodstream infection, suggesting potential for invasive disease.
AB - The introduction of the 7-valent pneumococcal conjugate vaccine in Portugal resulted in reduced carriage in children by vaccine-type strains and an increased carriage of three major antibiotic-resistant clones, ST2191, ST276, and ST63 expressing capsules 6A, 19A, and 15A, respectively. Pneumococcal otitis media (OM), a frequent infection among preschool age children, is often associated with viral coinfection. To evaluate the ability of these three antibiotic-resistant clones to cause disease, we used an infant mouse model of influenza virus pneumococcal coinfection. The 6A and 19A clonal types induced OM, while 15A induced pneumococcal pneumonia and bloodstream infection, suggesting potential for invasive disease.
UR - http://www.scopus.com/inward/record.url?scp=84954101743&partnerID=8YFLogxK
U2 - 10.1089/mdr.2015.0109
DO - 10.1089/mdr.2015.0109
M3 - Article
AN - SCOPUS:84954101743
VL - 22
SP - 97
EP - 101
JO - Microbial Drug Resistance
JF - Microbial Drug Resistance
SN - 1076-6294
IS - 1
ER -