A Workflow for the Application of Biclustering to Mass Spectrometry Data

H. López-Fernández, Miguel Reboiro-Jato, S. C. Madeira, Rubén López-Cortés, Júlio D. Nunes-Miranda, H. M. Santos, Florentino Fdez-Riverola, D. Glez-Peña

Research output: Chapter in Book/Report/Conference proceedingConference contributionpeer-review

3 Citations (Scopus)

Abstract

Biclustering techniques have been successfully applied to analyze microarray data and they begin to be applied to the analysis of mass spectrometry data, a high-throughput technology for proteomic data analysis which has been an active research area during the last years. In this work, we propose a novel workflow to the application of biclustering to MALDI-TOF mass spectrometry data, supported by a software desktop application which covering all of its stages. We evaluate the adequacy of applying biclustering to analyze mass spectrometry by comparing between biclustering and hierarchical clustering over two real datasets. Results are promising since they revealed the ability of these techniques to extract useful information, opening a door to further works. © Springer International Publishing Switzerland 2013.
Original languageEnglish
Title of host publication7th International Conference on Practical Applications of Computational Biology & Bioinformatics (PACBB 2013)
EditorsM. Mohamad , L. Nanni, M. Rocha , F. Fdez-Riverola
Place of PublicationHeidelberg
PublisherSpringer International Publishing
Pages145-153
Number of pages9
ISBN (Electronic)978-3-319-00578-2
ISBN (Print)978-3-319-00577-5
DOIs
Publication statusPublished - 2013
Event7th International Conference on Practical Applications of Computational Biology & Bioinformatics (PACBB 2013) - Salamanca, Spain
Duration: 22 May 201324 May 2013
Conference number: 7th

Publication series

NameAdvances in Intelligent Systems and Computing
Publisher Springer International Publishing
Volume222
ISSN (Print)2194-5357
ISSN (Electronic)2194-5365

Conference

Conference7th International Conference on Practical Applications of Computational Biology & Bioinformatics (PACBB 2013)
Abbreviated titlePACBB 2013
CountrySpain
CitySalamanca
Period22/05/1324/05/13

Keywords

  • BiBit
  • biclustering
  • Bimax
  • BiMS
  • mass spectrometry
  • Application programs
  • Bioinformatics
  • Data processing
  • Bi-clustering
  • Hier-archical clustering
  • High-throughput technologies
  • MALDI-TOF mass spectrometry
  • Mass spectrometry data
  • Mass spectrometry

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