A Tentative Classification of Antioxidants

Which Role They Play when Protecting Biological Targets from Oxidative Stress Induced Damage?

Abel José de Sousa Costa Vieira, Pedro Santos

Research output: Contribution to journal › Article

Abstract

By studying the protection of oxidative stress induced damage
in biomolecules by several groups of antioxidants, from the “side
of the antioxidant”, that is, by observing the reaction of the
antioxidant itself with an oxidizing species and characterizing the
resulting products, it was possible to classify the antioxidants into
three different kinds. An antioxidant can act as a scavenger of the
oxidizing species, repair a damaged biological molecule, or give
new products with antioxidising activity, starting an antioxidising
cascade. These three effects – scavenging, repair and cascade –
can act in a separate or a cumulative way. This new classification
of antioxidants by type of action can bring a new insight on
the comprehension of the protection mechanisms and open
perspectives to the design of new and more efficient antioxidants
Original languageEnglish
Pages (from-to)1-3
JournalJ Med Chem Drug Des
DOIs
Publication statusPublished - 2017

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Oxidative stress
Antioxidants
Repair
Scavenging
Biomolecules
Molecules

Keywords

  • Antioxidants
  • Scavenging
  • Repair
  • Cascade

Cite this

Vieira, Abel José de Sousa Costa ; Santos, Pedro. / A Tentative Classification of Antioxidants : Which Role They Play when Protecting Biological Targets from Oxidative Stress Induced Damage?. In: J Med Chem Drug Des. 2017 ; pp. 1-3.
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abstract = "By studying the protection of oxidative stress induced damage in biomolecules by several groups of antioxidants, from the “side of the antioxidant”, that is, by observing the reaction of the antioxidant itself with an oxidizing species and characterizing the resulting products, it was possible to classify the antioxidants into three different kinds. An antioxidant can act as a scavenger of the oxidizing species, repair a damaged biological molecule, or give new products with antioxidising activity, starting an antioxidising cascade. These three effects – scavenging, repair and cascade – can act in a separate or a cumulative way. This new classification of antioxidants by type of action can bring a new insight on the comprehension of the protection mechanisms and open perspectives to the design of new and more efficient antioxidants",
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Vieira, AJDSC & Santos, P 2017, 'A Tentative Classification of Antioxidants: Which Role They Play when Protecting Biological Targets from Oxidative Stress Induced Damage?', J Med Chem Drug Des, pp. 1-3. https://doi.org/10.16966/jmcdd.101

A Tentative Classification of Antioxidants : Which Role They Play when Protecting Biological Targets from Oxidative Stress Induced Damage? / Vieira, Abel José de Sousa Costa; Santos, Pedro.

In: J Med Chem Drug Des, 2017, p. 1-3.

Research output: Contribution to journal › Article

TY - JOUR

T1 - A Tentative Classification of Antioxidants

T2 - Which Role They Play when Protecting Biological Targets from Oxidative Stress Induced Damage?

AU - Vieira, Abel José de Sousa Costa

AU - Santos, Pedro

PY - 2017

Y1 - 2017

N2 - By studying the protection of oxidative stress induced damage in biomolecules by several groups of antioxidants, from the “side of the antioxidant”, that is, by observing the reaction of the antioxidant itself with an oxidizing species and characterizing the resulting products, it was possible to classify the antioxidants into three different kinds. An antioxidant can act as a scavenger of the oxidizing species, repair a damaged biological molecule, or give new products with antioxidising activity, starting an antioxidising cascade. These three effects – scavenging, repair and cascade – can act in a separate or a cumulative way. This new classification of antioxidants by type of action can bring a new insight on the comprehension of the protection mechanisms and open perspectives to the design of new and more efficient antioxidants

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KW - Antioxidants

KW - Scavenging

KW - Repair

KW - Cascade

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Vieira AJDSC, Santos P. A Tentative Classification of Antioxidants: Which Role They Play when Protecting Biological Targets from Oxidative Stress Induced Damage? J Med Chem Drug Des. 2017;1-3. https://doi.org/10.16966/jmcdd.101

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