A simple sol-gel route to the construction of hydroxyapatite inverted colloidal crystals for bone tissue engineering

Carlos João, Rute Almeida, Jorge AMC Silva, João Borges

Research output: Contribution to journalArticle

13 Citations (Scopus)

Abstract

Hydroxyapatite (HAp) scaffolds with uniform pore size and interconnected pore network were constructed based on the inverted colloidal crystal (ICC) geometry and a simple sol-gel formulation. Monodisperse polystyrene microspheres were self-assembled and annealed into a hexagonal close packed structure. HAp sol-gel was infiltrated in this template followed by thermal treatment for simultaneous HAp matrix sintering and polymeric colloidal crystal calcination. The resultant ICC scaffolds exhibit an ordered architecture that was able to offer a favorable environment for human osteoblasts adhesion and proliferation, an essential feature for bone ingrowth in tissue engineering applications.
Original languageEnglish
Pages (from-to)407-410
Number of pages4
JournalMaterials Letters
Volume185
DOIs
Publication statusPublished - 15 Dec 2016

Keywords

  • Hydroxyapatite
  • Sol-gel
  • Inverted colloidal crystals
  • Bone tissue engineering

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