A Simple Route Toward New Clomiphene Metabolites

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Abstract

A new clomiphene metabolite, extremely useful for doping analysis, was synthesized in 19% overall yield. The approach involved a Grignard reaction via a N-acylbenzotriazole intermediate to afford a key aromatic ketone and a HWE reaction. Both stereoisomers were separated and identified.
Original languageUnknown
Pages (from-to)753-756
JournalSynlett
Volumen/d
Issue number5
Publication statusPublished - 1 Jan 2010

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