TY - JOUR
T1 - A review on medicinal plants used for treating ototoxicity and acoustic trauma induced hearing loss
AU - Mahmoudian-Sani, Mohammad Reza
AU - Sheikhshabani, Somayeh Hashemi
AU - Mirfakhar, Farzaneh Sadat
AU - Asgharzade, Samira
PY - 2019
Y1 - 2019
N2 - Hearing loss induced by chemotherapy and acoustic trauma is mainly associated with two factors, free radical formation and apoptosis pathway activation. Despite numerous efforts on reducing the effects of these factors, no definite strategy is still determined to interfere with and control these processes. In recent studies, various protective agents, including antioxidants have been used on animal models, to inhibit the formation of free radicals thus improving hearing loss.In this review article we will discuss the role of traditional herbal medicine in treatment of noise/drug induced hearing loss, focusing on medicinal plants’ active substances,as well as their mechanisms of action in reducing or preventing the formation of free radicals thus increasing the rate of survival of cochlea cells. Data have been gathered since year 2000, from scientific publications including the following keywords: deafness, drug toxicity, acute trauma, medicinal herbs and oxidative stress. The study includes all herbs and medicinal plants that have been experimentally used in studies on animal models and clinical trials. The results from these studies indicate the effectiveness of most of these herbs and their active substances through their antioxidative properties. Medicinal plants reported in this review can thus be considered as effective remedies intreating noise/drug induced hearing loss,yet further studies need to be done.
AB - Hearing loss induced by chemotherapy and acoustic trauma is mainly associated with two factors, free radical formation and apoptosis pathway activation. Despite numerous efforts on reducing the effects of these factors, no definite strategy is still determined to interfere with and control these processes. In recent studies, various protective agents, including antioxidants have been used on animal models, to inhibit the formation of free radicals thus improving hearing loss.In this review article we will discuss the role of traditional herbal medicine in treatment of noise/drug induced hearing loss, focusing on medicinal plants’ active substances,as well as their mechanisms of action in reducing or preventing the formation of free radicals thus increasing the rate of survival of cochlea cells. Data have been gathered since year 2000, from scientific publications including the following keywords: deafness, drug toxicity, acute trauma, medicinal herbs and oxidative stress. The study includes all herbs and medicinal plants that have been experimentally used in studies on animal models and clinical trials. The results from these studies indicate the effectiveness of most of these herbs and their active substances through their antioxidative properties. Medicinal plants reported in this review can thus be considered as effective remedies intreating noise/drug induced hearing loss,yet further studies need to be done.
KW - Acoustic Trauma/ physiopathology
KW - Antioxidants/ therapeutic use
KW - Hearing Loss
KW - Hearing Loss/ prevention & control
KW - Herbal Medicine/ instrumentation
KW - Medicinal/ drug effects
KW - Noise-Induced/ therapy
KW - Ototoxicity
KW - Oxidative stress/ drug effects
KW - Plants
UR - http://www.scopus.com/inward/record.url?scp=85078362543&partnerID=8YFLogxK
U2 - 10.1590/s2175-97902019000218311
DO - 10.1590/s2175-97902019000218311
M3 - Review article
AN - SCOPUS:85078362543
SN - 1984-8250
VL - 55
JO - Brazilian Journal of Pharmaceutical Sciences
JF - Brazilian Journal of Pharmaceutical Sciences
M1 - e18311
ER -