Abstract
The current survey aims to describe the main methodologies for extending the reconstruction and analysis of genome-scale metabolic models and phenotype simulation with Flux Balance Analysis mathematical frameworks, via the integration of Transcriptional Regulatory Networks and/or gene expression data. Although the surveyed methods are aimed at improving phenotype simulations obtained from these models, the perspective of reconstructing integrated genome-scale models of metabolism and gene expression for diverse prokaryotes is still an open challenge.
Original language | English |
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Pages (from-to) | 1889-1903 |
Number of pages | 15 |
Journal | Biochemical Society Transactions |
Volume | 48 |
Issue number | 5 |
DOIs | |
Publication status | Published - Oct 2020 |