A review of methods for the reconstruction and analysis of integrated genome-scale models of metabolism and regulation

Fernando Cruz, José P. Faria, Miguel P. Rocha, Isabel Rocha, Oscar Dias

Research output: Contribution to journalReview article

1 Citation (Scopus)

Abstract

The current survey aims to describe the main methodologies for extending the reconstruction and analysis of genome-scale metabolic models and phenotype simulation with Flux Balance Analysis mathematical frameworks, via the integration of Transcriptional Regulatory Networks and/or gene expression data. Although the surveyed methods are aimed at improving phenotype simulations obtained from these models, the perspective of reconstructing integrated genome-scale models of metabolism and gene expression for diverse prokaryotes is still an open challenge.

Original languageEnglish
Pages (from-to)1889-1903
Number of pages15
JournalBiochemical Society Transactions
Volume48
Issue number5
DOIs
Publication statusPublished - Oct 2020

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