A radical approach towards indolizidine 167B

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Abstract

The alkaloids (+)- and (-)-indolizidine 167B were synthesized via radical addition of a carbon radical to a chiral acrylamide. Further cyclization in the presence of BBr3, treatment with 'nickel boride' and stereospecific hydrogenation over palladium/carbon in acetic acid were other key steps in this synthesis.

Original languageEnglish
Pages (from-to)455-458
Number of pages4
JournalTetrahedron Letters
Volume43
Issue number3
DOIs
Publication statusPublished - 14 Jan 2002

Keywords

  • Alkaloids
  • Indolizidines
  • Radicals and radical reactions
  • Stereocontrol

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