A radical approach towards indolizidine 167B

Marta C. Corvo; M. M. A. Pereira

doi:10.1016/S0040-4039(01)02189-X

A radical approach towards indolizidine 167B

Marta C. Corvo, M. M. A. Pereira

Research output: Contribution to journal › Article

42 Citations (Scopus)

Abstract

The alkaloids (+)- and (-)-indolizidine 167B were synthesized via radical addition of a carbon radical to a chiral acrylamide. Further cyclization in the presence of BBr₃, treatment with 'nickel boride' and stereospecific hydrogenation over palladium/carbon in acetic acid were other key steps in this synthesis.

Original language	English
Pages (from-to)	455-458
Number of pages	4
Journal	Tetrahedron Letters
Volume	43
Issue number	3
DOIs	https://doi.org/10.1016/S0040-4039(01)02189-X
Publication status	Published - 14 Jan 2002

Keywords

Alkaloids
Indolizidines
Radicals and radical reactions
Stereocontrol

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10.1016/S0040-4039(01)02189-XLicence: CC BY-NC-ND

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Corvo, M. C., & Pereira, M. M. A. (2002). A radical approach towards indolizidine 167B. Tetrahedron Letters, 43(3), 455-458. https://doi.org/10.1016/S0040-4039(01)02189-X

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abstract = "The alkaloids (+)- and (-)-indolizidine 167B were synthesized via radical addition of a carbon radical to a chiral acrylamide. Further cyclization in the presence of BBr3, treatment with 'nickel boride' and stereospecific hydrogenation over palladium/carbon in acetic acid were other key steps in this synthesis.",

keywords = "Alkaloids, Indolizidines, Radicals and radical reactions, Stereocontrol",

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AB - The alkaloids (+)- and (-)-indolizidine 167B were synthesized via radical addition of a carbon radical to a chiral acrylamide. Further cyclization in the presence of BBr3, treatment with 'nickel boride' and stereospecific hydrogenation over palladium/carbon in acetic acid were other key steps in this synthesis.

KW - Alkaloids

KW - Indolizidines

KW - Radicals and radical reactions

KW - Stereocontrol

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