Abstract
The alkaloids (+)- and (-)-indolizidine 167B were synthesized via radical addition of a carbon radical to a chiral acrylamide. Further cyclization in the presence of BBr3, treatment with 'nickel boride' and stereospecific hydrogenation over palladium/carbon in acetic acid were other key steps in this synthesis.
Original language | English |
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Pages (from-to) | 455-458 |
Number of pages | 4 |
Journal | Tetrahedron Letters |
Volume | 43 |
Issue number | 3 |
DOIs | |
Publication status | Published - 14 Jan 2002 |
Keywords
- Alkaloids
- Indolizidines
- Radicals and radical reactions
- Stereocontrol