Addressing the question of the limits of knowledge implies, first of all, the assumption that human beings have always longed for the Absolute, as expressed in diverse religions. However, when discussing science, problems must be properly characterized. Firstly, the genesis of the endeavour generally known as Modern Science must be contextualized. Subsequently, in today’s science of AI, it should be borne in mind that it is an area of knowledge related not only to cognition but also to the creation of sensors, processors and actuators that are critical to the creation of new knowledge. To this end, specific scientific methods need to be made explicit. As for the specific question of limits, it will be argued that the production of knowledge has not proven to be limited a priori. Certainly, such limits remain unknown. Either way, the question of limits is worth exploring. Lastly, the notion of symbiosis plays a key role in the increasingly diversified surrounding cognitive environment.