A promising road with challenges: where are gold nanoparticles in translational research?

Chenchen Bao, Joao Conde, Ester Polo, Pablo del Pino, Maria Moros, Pedro Baptista, Valeria Grazu, Daxiang Cui, Jesus M. de la Fuente

Research output: Contribution to journalArticle

45 Citations (Scopus)

Abstract

Nanoenabled technology holds great potential for health issues and biological research. Among the numerous inorganic nanoparticles that are available today, gold nanoparticles are fully developed as therapeutic and diagnostic agents both in vitro and in vivo due to their physicochemical properties. Owing to this, substantial work has been conducted in terms of developing biosensors for noninvasive and targeted tumor diagnosis and treatment. Some studies have even expanded into clinical trials. This article focuses on the fundamentals and synthesis of gold nanoparticles, as well as the latest, most promising applications in cancer research, such as molecular diagnostics, immunosensors, surface-enhanced Raman spectroscopy and bioimaging. Challenges to their further translational development are also discussed.

Original languageEnglish
Pages (from-to)2353-2370
Number of pages18
JournalNanomedicine
Volume9
Issue number15
DOIs
Publication statusPublished - 2014

Keywords

  • biomedical diagnostics
  • gold nanoparticles
  • nanomedicine
  • translational research
  • SURFACE-PLASMON RESONANCE
  • IN-VIVO
  • GENOMIC DNA
  • COLORIMETRIC DETECTION
  • PHOTOTHERMAL THERAPY
  • COMPUTED-TOMOGRAPHY
  • CONTRAST AGENT
  • METAL NANOPARTICLES
  • OPTICAL-DETECTION
  • IMAGING-SYSTEM

Cite this

Bao, C., Conde, J., Polo, E., del Pino, P., Moros, M., Baptista, P., ... de la Fuente, J. M. (2014). A promising road with challenges: where are gold nanoparticles in translational research? Nanomedicine, 9(15), 2353-2370. https://doi.org/10.2217/NNM.14.155