Abstract
In this report we show that inactivation of the putative nitroreductase SA0UHSC_00833 (ntrA) increases the sensitivity of Staphylococcus aureus to S-nitrosoglutathione (GSNO) and augments its resistance to nitrofurans. S. aureus NtrA is a bifunctional enzyme that exhibits nitroreductase and GSNO reductase activity. A phylogenetic analysis suggests that NtrA is a member of a novel family of nitroreductases that seems to play a dual role in vivo, promoting nitrofuran activation and protecting the cell against transnitrosylation.
| Original language | Unknown |
|---|---|
| Pages (from-to) | 3403-3406 |
| Journal | Journal of Bacteriology |
| Volume | 191 |
| Issue number | 10 |
| DOIs | |
| Publication status | Published - 1 Jan 2009 |