A Novel Nitroreductase of Staphylococcus aureus with S-Nitrosoglutathione Reductase Activity

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Abstract

In this report we show that inactivation of the putative nitroreductase SA0UHSC_00833 (ntrA) increases the sensitivity of Staphylococcus aureus to S-nitrosoglutathione (GSNO) and augments its resistance to nitrofurans. S. aureus NtrA is a bifunctional enzyme that exhibits nitroreductase and GSNO reductase activity. A phylogenetic analysis suggests that NtrA is a member of a novel family of nitroreductases that seems to play a dual role in vivo, promoting nitrofuran activation and protecting the cell against transnitrosylation.
Original languageUnknown
Pages (from-to)3403-3406
JournalJournal of Bacteriology
Volume191
Issue number10
DOIs
Publication statusPublished - 1 Jan 2009

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