A Mathematical Treatment of the Fluorescence Capillary-Fill Device

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Abstract

A mathematical model in the form of two coupled diffusion equations is provided for a competitive chemical reaction between an antigen and a labeled antigen for antibody sites on a cell wall; boundary conditions are such that the problem is both nonlinear and nonlocal. This is then recharacterized first as a pair of coupled singular integro-differential equations and then as a system of four Volterra integral equations. The latter permits a proof of existence and uniqueness of the solution of the original problem. Small and large time asymptotic solutions are derived and, from the first characterization, a regular perturbation solution is obtained. Numerical schemes are briefly discussed and graphical results are presented for human immunoglobulin
Original languageUnknown
Pages (from-to)1081-1112
JournalSiam Journal On Applied Mathematics
Volume72
Issue number4
DOIs
Publication statusPublished - 1 Jan 2012

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