TY - JOUR
T1 - A look beyond dietary (poly)phenols
T2 - The low molecular weight phenolic metabolites and their concentrations in human circulation
AU - Carregosa, Diogo
AU - Pinto, Catarina
AU - Ávila-Gálvez, María Ángeles
AU - Bastos, Paulo
AU - Berry, David
AU - Santos, Cláudia Nunes
N1 - Funding Information:
European Research Council (ERC) under the European Union's Horizon 2020 research and innovation programme under grant agreement No 804229. iNOVA4Health Research Unit (LISBOA‐01‐0145‐FEDER‐007344), which is cofunded by Fundação para a Ciência e Tecnologia (FCT) / Ministério da Ciéncia e do Ensino Superior, through national funds, and by FEDER under the PT2020 Partnership Agreement, European Research Council (Starting Grant: FunKeyGut 741623). FCT (2020.04630.BD).
Funding Information:
This work has received funding from the European Research Council (ERC) under the European Union's Horizon 2020 research and innovation programme under grant agreement No 804229. iNOVA4Health Research Unit (LISBOA‐01‐0145‐FEDER‐007344), which is cofunded by Fundação para a Ciência e Tecnologia (FCT) / Ministério da Ciência e do Ensino Superior, through national funds, and by FEDER under the PT2020 Partnership Agreement, is acknowledged. D.B. acknowledges funding by the European Research Council (Starting Grant: FunKeyGut 741623). Authors would like to acknowledge FCT for financial support of D.C. (2020.04630.BD).
Publisher Copyright:
© 2022 The Authors. Comprehensive Reviews in Food Science and Food Safety published by Wiley Periodicals LLC on behalf of Institute of Food Technologists.
PY - 2022/9
Y1 - 2022/9
N2 - A large number of epidemiological studies have shown that consumption of fruits, vegetables, and beverages rich in (poly)phenols promote numerous health benefits from cardiovascular to neurological diseases. Evidence on (poly)phenols has been applied mainly to flavonoids, yet the role of phenolic acids has been largely overlooked. Such phenolics present in food combine with those resulting from gut microbiota catabolism of flavonoids and chlorogenic acids and those produced by endogenous pathways, resulting in large concentrations of low molecular weight phenolic metabolites in human circulation. Independently of the origin, in human intervention studies using diets rich in (poly)phenols, a total of 137 low molecular weight phenolic metabolites have been detected and quantified in human circulation with largely unknown biological function. In this review, we will pinpoint two main aspects of the low molecular weight phenolic metabolites: (i) the microbiota responsible for their generation, and (ii) the analysis (quali- and quantitative) in human circulation and their respective pharmacokinetics. In doing so, we aim to drive scientific advances regarding the ubiquitous roles of low molecular weight phenolic metabolites using physiologically relevant concentrations and under (patho)physiologically relevant conditions in humans.
AB - A large number of epidemiological studies have shown that consumption of fruits, vegetables, and beverages rich in (poly)phenols promote numerous health benefits from cardiovascular to neurological diseases. Evidence on (poly)phenols has been applied mainly to flavonoids, yet the role of phenolic acids has been largely overlooked. Such phenolics present in food combine with those resulting from gut microbiota catabolism of flavonoids and chlorogenic acids and those produced by endogenous pathways, resulting in large concentrations of low molecular weight phenolic metabolites in human circulation. Independently of the origin, in human intervention studies using diets rich in (poly)phenols, a total of 137 low molecular weight phenolic metabolites have been detected and quantified in human circulation with largely unknown biological function. In this review, we will pinpoint two main aspects of the low molecular weight phenolic metabolites: (i) the microbiota responsible for their generation, and (ii) the analysis (quali- and quantitative) in human circulation and their respective pharmacokinetics. In doing so, we aim to drive scientific advances regarding the ubiquitous roles of low molecular weight phenolic metabolites using physiologically relevant concentrations and under (patho)physiologically relevant conditions in humans.
KW - metabolism
KW - microbiota
KW - polyphenols
UR - http://www.scopus.com/inward/record.url?scp=85137251237&partnerID=8YFLogxK
U2 - 10.1111/1541-4337.13006
DO - 10.1111/1541-4337.13006
M3 - Article
AN - SCOPUS:85137251237
SN - 1541-4337
VL - 21
SP - 3931
EP - 3962
JO - Comprehensive Reviews in Food Science and Food Safety
JF - Comprehensive Reviews in Food Science and Food Safety
IS - 5
ER -
