A Hypothetical Model of The Flavodoxin—Tetraheme Cytochrome C3complex of Sulfate-reducing Bacteria

D. E. Stewart, J. LeGall, I. Moura, José J. G. Moura, H. D. Peck, A. V. Xavier, P. K. Weiner, J. E. Wampler

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48 Citations (Scopus)

Abstract

A hypothetical model of the flavodoxin—tetraheme cytochrome c3electron-transfer complex from the sulfate-reducing bacterium Desulfovibrio vulgaris has been constructed by using interactive computer graphics based onelectrostatic potential field calculations and previous NMR experiments. Features of the proposed complex are (1) van derWaals contact between the flavin mononucleotide prosthetic group of flavodoxin and one heme of the cytochrome, (2) uniquecomplementarity of electrostatic fields between the region surrounding this heme and the region surrounding the exposed portion of the flavin mononucleotide group of flavodoxin, and (3) no steric interferences between the two polypeptide chains in the complex. This complex is consistent with all structural and spectroscopic data available.

Original languageEnglish
Pages (from-to)2444-2450
Number of pages7
JournalBiochemistry
Volume27
Issue number7
DOIs
Publication statusPublished - 1 Apr 1988

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