A homocisteinemia como factor de risco de doença cerebrovascular precoce

Translated title of the contribution: Homocysteinemia as a risk factor in early cerebrovascular disease

R. P. Reis, J. Azinheira, H. P. Reis, M. Pereira, A. Baptista, M. Crespo, J. E. Pina, N. C. Ferreira, A. S. Luís

Research output: Contribution to journalArticlepeer-review

8 Citations (Scopus)
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PURPOSE: To determine whether hyperhomocysteinemia represents a risk factor of early thrombotic cerebrovascular disease. METHOD: In a group of patients under 55 years of age (n = 33, 19 males) which had suffered a stroke from 3 months to 1 year before the study, defined by clinical criteria and presence of cerebral infarction confirmed by tomography, without history or predisposition to embolic disease. The patients were matched with a group of normal controls of checkup program, in terms of age, and sex. Patients and controls with a history of alcoholism, clinical or laboratory signs of renal or hepatic insufficiency or with a history of recent ingestion of Group B vitamins were excluded since these conditions would influence homocysteinemia levels. We measured the plasmatic basal homocysteinemia of patients and controls (HC) and 6 hours later a methionine overload of 0.1 g/Kg body weight (LOAD HC). RESULTS: Patients; Controls; Signific.; Age 46.0 +/- 7.7; 45.9 +/- 7.8; NS; Basal HC. 10.1 +/- 3.4; 8.5 +/- 1.7; p < 0.05; Load HC 28.0 +/- 7.6; 22.7 +/- 5.5; p < 0.01. CONCLUSION: In this study hyperhomocysteinemia appears as a risk factor for thrombotic cerebrovascular disease before the age of 55;-The measurement of homocysteinemia after the methionine loading test was more discriminative than the basal measurement;-A larger number of patients and controls will be necessary to establish the relative importance of homocysteinemia among other vascular risk factors in cerebrovascular disease.

Translated title of the contributionHomocysteinemia as a risk factor in early cerebrovascular disease
Original languagePortuguese
Pages (from-to)285-289
Number of pages5
JournalActa Médica Portuguesa
Issue number5
Publication statusPublished - 1 May 1994


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