A GBF1-Dependent Mechanism for Environmentally Responsive Regulation of ER-Golgi Transport

Mafalda Lopes-da-Silva; Jessica J. McCormack; Jemima J. Burden; Kimberly J. Harrison-Lavoie; Francesco Ferraro; Daniel F. Cutler

doi:10.1016/j.devcel.2019.04.006

A GBF1-Dependent Mechanism for Environmentally Responsive Regulation of ER-Golgi Transport

Mafalda Lopes-da-Silva, Jessica J. McCormack, Jemima J. Burden, Kimberly J. Harrison-Lavoie, Francesco Ferraro, Daniel F. Cutler

Research output: Contribution to journal › Article › peer-review

34 Citations (Scopus)

Abstract

da Silva et al. examine how the secretory pathway is coupled to environmental cues. They show that suppression of GBF1, the GEF for two Golgi Arfs (1 and 4), slows exit from the ER and the TGN. GBF1 can be phosphorylated by AMPK, and metabolic activation or inhibition of AMPK controls anterograde traffic.

Original language	English
Pages (from-to)	786-+
Journal	Developmental Cell
Volume	49
Issue number	5
DOIs	https://doi.org/10.1016/j.devcel.2019.04.006
Publication status	Published - 3 Jun 2019

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title = "A GBF1-Dependent Mechanism for Environmentally Responsive Regulation of ER-Golgi Transport",

abstract = "da Silva et al. examine how the secretory pathway is coupled to environmental cues. They show that suppression of GBF1, the GEF for two Golgi Arfs (1 and 4), slows exit from the ER and the TGN. GBF1 can be phosphorylated by AMPK, and metabolic activation or inhibition of AMPK controls anterograde traffic.",

author = "Mafalda Lopes-da-Silva and McCormack, {Jessica J.} and Burden, {Jemima J.} and Harrison-Lavoie, {Kimberly J.} and Francesco Ferraro and Cutler, {Daniel F.}",

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AU - Lopes-da-Silva, Mafalda

AU - McCormack, Jessica J.

AU - Burden, Jemima J.

AU - Harrison-Lavoie, Kimberly J.

AU - Ferraro, Francesco

AU - Cutler, Daniel F.

PY - 2019/6/3

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N2 - da Silva et al. examine how the secretory pathway is coupled to environmental cues. They show that suppression of GBF1, the GEF for two Golgi Arfs (1 and 4), slows exit from the ER and the TGN. GBF1 can be phosphorylated by AMPK, and metabolic activation or inhibition of AMPK controls anterograde traffic.

AB - da Silva et al. examine how the secretory pathway is coupled to environmental cues. They show that suppression of GBF1, the GEF for two Golgi Arfs (1 and 4), slows exit from the ER and the TGN. GBF1 can be phosphorylated by AMPK, and metabolic activation or inhibition of AMPK controls anterograde traffic.

U2 - 10.1016/j.devcel.2019.04.006

DO - 10.1016/j.devcel.2019.04.006

M3 - Article

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VL - 49

SP - 786-+

JO - Developmental Cell

JF - Developmental Cell

IS - 5

ER -

A GBF1-Dependent Mechanism for Environmentally Responsive Regulation of ER-Golgi Transport

Abstract

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