A GBF1-Dependent Mechanism for Environmentally Responsive Regulation of ER-Golgi Transport

Mafalda Lopes-da-Silva, Jessica J. McCormack, Jemima J. Burden, Kimberly J. Harrison-Lavoie, Francesco Ferraro, Daniel F. Cutler

Research output: Contribution to journalArticle

Abstract

da Silva et al. examine how the secretory pathway is coupled to environmental cues. They show that suppression of GBF1, the GEF for two Golgi Arfs (1 and 4), slows exit from the ER and the TGN. GBF1 can be phosphorylated by AMPK, and metabolic activation or inhibition of AMPK controls anterograde traffic.

Original languageEnglish
Pages (from-to)786-+
JournalDevelopmental Cell
Volume49
Issue number5
DOIs
Publication statusPublished - 3 Jun 2019

Cite this

Lopes-da-Silva, M., McCormack, J. J., Burden, J. J., Harrison-Lavoie, K. J., Ferraro, F., & Cutler, D. F. (2019). A GBF1-Dependent Mechanism for Environmentally Responsive Regulation of ER-Golgi Transport. Developmental Cell, 49(5), 786-+. https://doi.org/10.1016/j.devcel.2019.04.006