A discrete-choice experiment to assess patients’ preferences for osteoarthritis treatment: An ESCEO working group

Mickael Hiligsmann, Elaine Dennison, Charlotte Beaudart, Gabriel Herrero-Beaumont, Jaime Branco, Olivier Bruyère, Philip G. Conaghan, Cyrus Cooper, Nasser Al-Daghri, Famida Jiwa, Willem Lems, Daniel Pinto, Rene Rizzoli, Thierry Thomas, Daniel Uebelhart, Nicolas Veronese, Jean Yves Reginster

Research output: Contribution to journalArticle

Abstract

Objective: To evaluate the preferences of patients with osteoarthritis for treatment. Methods: A discrete-choice experiment was conducted among adult OA patients who were presented with 12 choice sets of two treatment options and asked in each to select the treatment they would prefer. Based on literature reviews, expert consultation, patient survey and expert meeting, treatment options were characterized by seven attributes: improvement in pain, improvement in walking, ability to manage domestic activities, ability to manage social activities, improvement in overall energy and well-being, risk of moderate/severe side effects and impact on disease progression. Random parameters logit model was used to estimate patients’ preferences and a latent class model was conducted to explore preferences classes. Results: 253 OA patients from seven European countries were included (74% women; mean age 71.3 years). For all seven treatment attributes, significant differences were observed between levels. Given the range of levels of each attribute, the most important treatment attribute in this group was impact on disease progression (29.5%) followed by walking improvement (17.1%) and pain improvement (16.3%). The latent class model identified two preference classes. In the first class (probability of 56%), patients valued impact of disease progression the most (39%). In the second class, walking improvement and improvement in overall energy and well-being were the most important (23%). Conclusion: This study suggests that all seven treatment attributes were important for OA patients. Overall, given the range of levels, the most important outcomes were impact on disease progression and improvement in pain and walking.

Original languageEnglish
Pages (from-to)859-866
Number of pages8
JournalSeminars in Arthritis and Rheumatism
Volume50
Issue number5
DOIs
Publication statusPublished - Oct 2020

Keywords

  • Discrete-choice experiment
  • Osteoarthritis
  • Outcomes
  • Patient preferences

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    Hiligsmann, M., Dennison, E., Beaudart, C., Herrero-Beaumont, G., Branco, J., Bruyère, O., Conaghan, P. G., Cooper, C., Al-Daghri, N., Jiwa, F., Lems, W., Pinto, D., Rizzoli, R., Thomas, T., Uebelhart, D., Veronese, N., & Reginster, J. Y. (2020). A discrete-choice experiment to assess patients’ preferences for osteoarthritis treatment: An ESCEO working group. Seminars in Arthritis and Rheumatism, 50(5), 859-866. https://doi.org/10.1016/j.semarthrit.2020.08.005