A Different Approach to the EGFR Inhibitor Gefitinib Involving Solid-Phase Synthesis

André Sequeira; Ana Lourenço; Luísa Maria Ferreira; Paula Sério Branco; Zita Mendes; Nuno M.T. Lourenço; Margarida Figueiredo; Luísa C.R. Carvalho

doi:10.1055/s-0037-1610127

A Different Approach to the EGFR Inhibitor Gefitinib Involving Solid-Phase Synthesis

André Sequeira, Ana Lourenço, Luísa Maria Ferreira, Paula Sério Branco, Zita Mendes, Nuno M.T. Lourenço, Margarida Figueiredo, Luísa C.R. Carvalho

Research output: Contribution to journal › Article › peer-review

4 Citations (Scopus)

Abstract

An efficient solid-phase synthesis approach is here reported for the first time to prepare the EGFR inhibitor Gefitinib. The five-step synthetic strategy used FMP resin as the solid support, and FTIR and colorimetric assays were used to track the reaction’s progress. Gefitinib was obtained with an overall yield of 40%.

Original language	English
Journal	Synlett
DOIs	https://doi.org/10.1055/s-0037-1610127
Publication status	Published - 2018

Keywords

colorimetric assays
FMP resin
Gefitinib
quinazoline
solid-phase synthesis

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10.1055/s-0037-1610127

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title = "A Different Approach to the EGFR Inhibitor Gefitinib Involving Solid-Phase Synthesis",

abstract = "An efficient solid-phase synthesis approach is here reported for the first time to prepare the EGFR inhibitor Gefitinib. The five-step synthetic strategy used FMP resin as the solid support, and FTIR and colorimetric assays were used to track the reaction{\textquoteright}s progress. Gefitinib was obtained with an overall yield of 40\%.",

keywords = "colorimetric assays, FMP resin, Gefitinib, quinazoline, solid-phase synthesis",

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year = "2018",

doi = "10.1055/s-0037-1610127",

language = "English",

journal = "Synlett",

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TY - JOUR

T1 - A Different Approach to the EGFR Inhibitor Gefitinib Involving Solid-Phase Synthesis

AU - Sequeira, André

AU - Lourenço, Ana

AU - Ferreira, Luísa Maria

AU - Branco, Paula Sério

AU - Mendes, Zita

AU - Lourenço, Nuno M.T.

AU - Figueiredo, Margarida

AU - Carvalho, Luísa C.R.

N1 - info:eu-repo/grantAgreement/FCT/5876/147218/PT# info:eu-repo/grantAgreement/FCT/3599-PPCDT/127013/PT# co-financed by the ERDF under the PT2020 Partnership Agreement (POCI-01-0145-FEDER-007265). Sem pdf.

PY - 2018

Y1 - 2018

N2 - An efficient solid-phase synthesis approach is here reported for the first time to prepare the EGFR inhibitor Gefitinib. The five-step synthetic strategy used FMP resin as the solid support, and FTIR and colorimetric assays were used to track the reaction’s progress. Gefitinib was obtained with an overall yield of 40%.

AB - An efficient solid-phase synthesis approach is here reported for the first time to prepare the EGFR inhibitor Gefitinib. The five-step synthetic strategy used FMP resin as the solid support, and FTIR and colorimetric assays were used to track the reaction’s progress. Gefitinib was obtained with an overall yield of 40%.

KW - colorimetric assays

KW - FMP resin

KW - Gefitinib

KW - quinazoline

KW - solid-phase synthesis

UR - https://www.scopus.com/pages/publications/85046757006

U2 - 10.1055/s-0037-1610127

DO - 10.1055/s-0037-1610127

M3 - Article

AN - SCOPUS:85046757006

SN - 0936-5214

JO - Synlett

JF - Synlett

ER -

A Different Approach to the EGFR Inhibitor Gefitinib Involving Solid-Phase Synthesis

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Keywords

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