A Different Approach to the EGFR Inhibitor Gefitinib Involving Solid-Phase Synthesis

André Sequeira, Ana Lourenço, Luísa Maria Ferreira, Paula Sério Branco, Zita Mendes, Nuno M.T. Lourenço, Margarida Figueiredo, Luísa C.R. Carvalho

Research output: Contribution to journalArticle

2 Citations (Scopus)

Abstract

An efficient solid-phase synthesis approach is here reported for the first time to prepare the EGFR inhibitor Gefitinib. The five-step synthetic strategy used FMP resin as the solid support, and FTIR and colorimetric assays were used to track the reaction’s progress. Gefitinib was obtained with an overall yield of 40%.

Original languageEnglish
JournalSynlett
DOIs
Publication statusPublished - 2018

Keywords

  • colorimetric assays
  • FMP resin
  • Gefitinib
  • quinazoline
  • solid-phase synthesis

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