@article{6ace07bd0df041268d7c272847bf21ee,
title = "A Different Approach to the EGFR Inhibitor Gefitinib Involving Solid-Phase Synthesis",
abstract = "An efficient solid-phase synthesis approach is here reported for the first time to prepare the EGFR inhibitor Gefitinib. The five-step synthetic strategy used FMP resin as the solid support, and FTIR and colorimetric assays were used to track the reaction{\textquoteright}s progress. Gefitinib was obtained with an overall yield of 40%.",
keywords = "colorimetric assays, FMP resin, Gefitinib, quinazoline, solid-phase synthesis",
author = "Andr{\'e} Sequeira and Ana Louren{\c c}o and Ferreira, {Lu{\'i}sa Maria} and Branco, {Paula S{\'e}rio} and Zita Mendes and Louren{\c c}o, {Nuno M.T.} and Margarida Figueiredo and Carvalho, {Lu{\'i}sa C.R.}",
note = "info:eu-repo/grantAgreement/FCT/5876/147218/PT# info:eu-repo/grantAgreement/FCT/3599-PPCDT/127013/PT# co-financed by the ERDF under the PT2020 Partnership Agreement (POCI-01-0145-FEDER-007265). Sem pdf.",
year = "2018",
doi = "10.1055/s-0037-1610127",
language = "English",
journal = "Synlett",
issn = "0936-5214",
publisher = "Georg Thieme Verlag",
}