TY - JOUR
T1 - A Decade of Biochemical and Structural Studies of the DNA Repair Machinery of Deinococcus radiodurans
T2 - Major Findings, Functional and Mechanistic Insight and Challenges
AU - Timmins, Joanna
AU - Moe, Elin
PY - 2016/1/1
Y1 - 2016/1/1
N2 - The Deinococcus radiodurans bacterium is extremely resistant to ionising radiation and desiccation and can withstand a 200-fold higher radiation dose than most other bacteria with no loss of viability. The mechanisms behind this extreme resistance are not fully understood, but it is clear that several factors contribute to this phenotype. Efficient scavenging of reactive oxygen species and repair of damaged DNA are two of these. In this review, we summarise the results froma decade of structural and functional studies of the DNA repair machinery of Deinococcus radiodurans and discuss how these studies have contributed to an improved understanding of the molecular mechanisms underlying DNA repair and to the outstanding resistance of Deinococcus radiodurans to DNA damaging agents.
AB - The Deinococcus radiodurans bacterium is extremely resistant to ionising radiation and desiccation and can withstand a 200-fold higher radiation dose than most other bacteria with no loss of viability. The mechanisms behind this extreme resistance are not fully understood, but it is clear that several factors contribute to this phenotype. Efficient scavenging of reactive oxygen species and repair of damaged DNA are two of these. In this review, we summarise the results froma decade of structural and functional studies of the DNA repair machinery of Deinococcus radiodurans and discuss how these studies have contributed to an improved understanding of the molecular mechanisms underlying DNA repair and to the outstanding resistance of Deinococcus radiodurans to DNA damaging agents.
UR - http://www.scopus.com/inward/record.url?scp=84969815928&partnerID=8YFLogxK
U2 - 10.1016/j.csbj.2016.04.001
DO - 10.1016/j.csbj.2016.04.001
M3 - Article
AN - SCOPUS:84969815928
VL - 14
SP - 168
EP - 176
JO - Computational and Structural Biotechnology Journal
JF - Computational and Structural Biotechnology Journal
SN - 2001-0370
ER -