A computational method for the identification of dengue, zika and chikungunya virus species and genotypes

Vagner S. Fonseca, Pieter J. K. Libin, Kristof Theys, Nuno Rodrigues Faria, Márcio Roberto Texeira Nunes, Maria I. Restovic, Murilo Freire, Marta Giovanetti, Lize Cuypers, Ann Nowé, AB Abecasis, Koen Deforche, Gilberto A. Santiago, Isadora Cristina de Siqueira, Emmanuel J. San, Kaliane C.B. Machado, Vasco Ariston De Carvalho Azevedo, Ana Maria Bispo de Filippis, Rivaldo Venâncio da Cunha, Oliver George PybusAM Vandamme, L. C. J. Alcantara, Túlio de Oliveira

Research output: Contribution to journalArticle

8 Citations (Scopus)

Abstract

In recent years, an increasing number of outbreaks of Dengue, Chikungunya and Zika viruses have been reported in Asia and the Americas. Monitoring virus genotype diversity is crucial to understand the emergence and spread of outbreaks, both aspects that are vital to develop effective prevention and treatment strategies. Hence, we developed an efficient method to classify virus sequences with respect to their species and sub-species (i.e. serotype and/or genotype). This tool provides an easy-to-use software implementation of this new method and was validated on a large dataset assessing the classification performance with respect to whole-genome sequences and partial-genome sequences.
Original languageEnglish
Article numbere0007231
Number of pages15
JournalPLoS Neglected Tropical Diseases
Volume13
Issue number5
DOIs
Publication statusPublished - 8 May 2019

UN Sustainable Development Goals (SDGs)

  • SDG 3 - Good Health and Well-Being

Fingerprint Dive into the research topics of 'A computational method for the identification of dengue, zika and chikungunya virus species and genotypes'. Together they form a unique fingerprint.

  • Cite this

    Fonseca, V. S., Libin, P. J. K., Theys, K., Faria, N. R., Nunes, M. R. T., Restovic, M. I., Freire, M., Giovanetti, M., Cuypers, L., Nowé, A., Abecasis, AB., Deforche, K., Santiago, G. A., de Siqueira, I. C., San, E. J., Machado, K. C. B., Azevedo, V. A. D. C., de Filippis, A. M. B., da Cunha, R. V., ... de Oliveira, T. (2019). A computational method for the identification of dengue, zika and chikungunya virus species and genotypes. PLoS Neglected Tropical Diseases, 13(5), [e0007231]. https://doi.org/10.1371/journal.pntd.0007231