15 years on siRNA delivery: Beyond the State-of-the-Art on inorganic nanoparticles for RNAi therapeutics

Joao Conde, Alfredo Ambrosone, Yulan Hernandez, Furong Tian, Mark McCully, Catherine C. Berry, Pedro Miguel Ribeiro Viana Baptista, Claudia Tortiglione, Jesus M. de la Fuente

Research output: Contribution to journalLiterature review

44 Citations (Scopus)

Abstract

RNAi has always captivated scientists due to its tremendous power to modulate the phenotype of living organisms. This natural and powerful biological mechanism can now be harnessed to downregulate specific gene expression in diseased cells, opening up endless opportunities. Since most of the conventional siRNA delivery methods are limited by a narrow therapeutic index and significant side and off-target effects, we are now in the dawn of a new age in gene therapy driven by nanotechnology vehicles for RNAi therapeutics. Here, we outlook the "do's and dont's" of the inorganic RNAi nanomaterials developed in the last 15 years and the different strategies employed are compared and scrutinized, offering important suggestions for the next 15. (C) 2015 Elsevier Ltd. All rights reserved.

Original languageEnglish
Pages (from-to)421-450
Number of pages30
JournalNano today
Volume10
Issue number4
DOIs
Publication statusPublished - Aug 2015

Keywords

  • RNAi therapy
  • siRNA delivery
  • Inorganic nanoparticles
  • Targeting
  • Nanotoxicity
  • Nanomedicine
  • MESOPOROUS SILICA NANOPARTICLES
  • SMALL INTERFERING RNA
  • COATED GOLD NANOPARTICLES
  • IRON-OXIDE NANOPARTICLES
  • OVERCOME DRUG-RESISTANCE
  • SUPPORTED LIPID-BILAYERS
  • LEUKEMIA K562 CELLS
  • DOUBLE-STRANDED-RNA
  • IN-VIVO
  • QUANTUM DOTS

Cite this

Conde, J., Ambrosone, A., Hernandez, Y., Tian, F., McCully, M., Berry, C. C., ... de la Fuente, J. M. (2015). 15 years on siRNA delivery: Beyond the State-of-the-Art on inorganic nanoparticles for RNAi therapeutics. Nano today, 10(4), 421-450. https://doi.org/10.1016/j.nantod.2015.06.008