Tiago Fleming Outeiro

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Tiago Fleming Outeiro

Prof. Dr.

Former affiliations
 https://orcid.org/0000-0003-1679-1727
Calculated based on number of publications stored in Pure and citations from Scopus
20112024

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  • 2024

    A small TAT-TrkB peptide prevents BDNF receptor cleavage and restores synaptic physiology in Alzheimer's disease

    Fonseca-Gomes, J., Costa-Coelho, T., Ferreira-Manso, M., Inteiro-Oliveira, S., Vaz, S. H., Alemãn-Serrano, N., Atalaia-Barbacena, H., Ribeiro-Rodrigues, L., Ramalho, R. M., Pinto, R., Vicente Miranda, H., Tanqueiro, S. R., de Almeida-Borlido, C., Ramalho, M. J., Miranda-Lourenço, C., Belo, R. F., Ferreira, C. B., Neves, V., Rombo, D. M., Viais, R., & 23 othersMartins, I. C., Jerónimo-Santos, A., Caetano, A., Manso, N., Mäkinen, P., Marttinen, M., Takalo, M., Bremang, M., Pike, I., Haapasalo, A., Loureiro, J. A., Pereira, M. C., Santos, N. C., Outeiro, T. F., Castanho, M. A. R. B., Fernandes, A., Hiltunen, M., Duarte, C. B., Castrén, E., de Mendonça, A., Sebastião, A. M., Rodrigues, T. M. & Diógenes, M. J., 2 Oct 2024, In: Molecular therapy : the journal of the American Society of Gene Therapy. 32, 10, p. 3372-3401 30 p.

    Research output: Contribution to journal › Article › peer-review

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    3 Citations (Scopus)
    20 Downloads (Pure)
  • 2023

    Genipin prevents alpha-synuclein aggregation and toxicity by affecting endocytosis, metabolism and lipid storage

    Rosado-Ramos, R., Poças, G. M., Marques, D., Foito, A., M Sevillano, D., Lopes-da-Silva, M., Gonçalves, L. G., Menezes, R., Ottens, M., Stewart, D., Ibáñez de Opakua, A., Zweckstetter, M., Seabra, M. C., Mendes, C. S., Outeiro, T. F., Domingos, P. M. & Santos, C. N., 6 Apr 2023, In: Nature Communications. 14, 1, p. 1918 1 p., 1918.

    Research output: Contribution to journal › Article › peer-review

    Open Access
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    9 Citations (Scopus)
    75 Downloads (Pure)
  • 2022

    Glycation modulates glutamatergic signaling and exacerbates Parkinson’s disease-like phenotypes

    Chegão, A., Guarda, M., Alexandre, B. M., Shvachiy, L., Temido-Ferreira, M., Marques-Morgado, I., Fernandes Gomes, B., Matthiesen, R., Lopes, L. V., Florindo, P. R., Gomes, R. A., Gomes-Alves, P., Coelho, J. E., Outeiro, T. F. & Vicente Miranda, H., 25 Apr 2022, In: npj Parkinson's Disease. 8, 1, 51.

    Research output: Contribution to journal › Article › peer-review

    Open Access
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    29 Citations (Scopus)
    62 Downloads (Pure)
  • 2021

    MPV17 Mutations Are Associated With a Quiescent Energetic Metabolic Profile

    Jacinto, S., Guerreiro, P., de Oliveira, R. M., Cunha-Oliveira, T., Santos, M. J., Grazina, M., Rego, A. C. & Outeiro, T. F., 17 Mar 2021, In: Frontiers in Cellular Neuroscience. 15, 641264.

    Research output: Contribution to journal › Article › peer-review

    Open Access
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    14 Citations (Scopus)
    35 Downloads (Pure)

  • Small molecule fisetin modulates alpha-Synuclein aggregation

    Rosado-Ramos, R., Godinho-Pereira, J., Marques, D., Figueira, I., Outeiro, T. F., Menezes, R. & Dos Santos, C. N., 1 Jun 2021, In: Molecules. 26, 11, 3353.

    Research output: Contribution to journal › Article › peer-review

    Open Access
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    16 Citations (Scopus)
    48 Downloads (Pure)
  • 2020

    Age-related shift in LTD is dependent on neuronal adenosine A receptors interplay with mGluR5 and NMDA receptors

    Temido-Ferreira, M., Ferreira, D. G., Batalha, V. L., Marques-Morgado, I., Coelho, J. E., Pereira, P., Gomes, R., Pinto, A., Carvalho, S., Canas, P. M., Cuvelier, L., Buée-Scherrer, V., Faivre, E., Baqi, Y., Müller, C. E., Pimentel, J., Schiffmann, S. N., Buée, L., Bader, M., Outeiro, T. F., & 5 othersBlum, D., Cunha, R. A., Marie, H., Pousinha, P. A. & Lopes, L. V., Aug 2020, In: Molecular Psychiatry. 25, 8, p. 1876-1900

    Research output: Contribution to journal › Article › peer-review

    136 Citations (Scopus)

  • Bioprospection of Natural Sources of Polyphenols with Therapeutic Potential for Redox-Related Diseases

    Menezes, R., Foito, A., Jardim, C., Costa, I., Garcia, G., Rosado-Ramos, R., Freitag, S., Alexander, C. J., Outeiro, T. F., Stewart, D. & Santos, C. N., Sept 2020, In: Antioxidants. 9, 9, 789.

    Research output: Contribution to journal › Article › peer-review

    Open Access
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    12 Citations (Scopus)
    63 Downloads (Pure)

  • Hsp27 reduces glycation-induced toxicity and aggregation of alpha-synuclein

    Vicente Miranda, H., Chegão, A., Oliveira, M. S., Fernandes Gomes, B., Enguita, F. J. & Outeiro, T. F., 1 May 2020, In: Faseb Journal. 34, 5, p. 6718-6728 11 p.

    Research output: Contribution to journal › Article › peer-review

    Open Access
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    20 Citations (Scopus)
    29 Downloads (Pure)

  • Identification of antiparkinsonian drugs in the 6-hydroxydopamine zebrafish model

    Vaz, R. L., Sousa, S., Chapela, D., van der Linde, H. C., Willemsen, R., Correia, A. D., Outeiro, T. F. & Afonso, N. D., 1 Feb 2020, In: Pharmacology Biochemistry and Behavior. 189, 172828.

    Research output: Contribution to journal › Article › peer-review

    21 Citations (Scopus)

  • Tapentadol Prevents Motor Impairments in a Mouse Model of Dyskinesia

    Vaz, R. L., Chapela, D., Coelho, J. E., Lopes, L. V., Ferreira, J. J., Afonso, N. D., Sousa, S. & Outeiro, T. F., 2020, In: Neuroscience. 424, p. 58-71 14 p.

    Research output: Contribution to journal › Article › peer-review

    2 Citations (Scopus)

  • The Neuroprotective Action of Amidated-Kyotorphin on Amyloid β Peptide-Induced Alzheimer’s Disease Pathophysiology

    Belo, R. F., Martins, M. L. F., Shvachiy, L., Costa-Coelho, T., de Almeida-Borlido, C., Fonseca-Gomes, J., Neves, V., Vicente Miranda, H., Outeiro, T. F., Coelho, J. E., Xapelli, S., Valente, C. A., Heras, M., Bardaji, E., Castanho, M. A. R. B., Diógenes, M. J. & Sebastião, A. M., 9 Jul 2020, In: Frontiers in Pharmacology. 11, 985.

    Research output: Contribution to journal › Article › peer-review

    Open Access
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    12 Citations (Scopus)
    70 Downloads (Pure)
  • 2019

    Large expert-curated database for benchmarking document similarity detection in biomedical literature search

    Brown, P., Tan, A-C., El-Esawi, M. A., Liehr, T., Blanck, O., Gladue, D. P., Almeida, G. M. F., Cernava, T., Sorzano, C. O., Yeung, A. W. K., Engel, M. S., Chandrasekaran, A. R., Muth, T., Staege, M. S., Daulatabad, S. V., Widera, D., Zhang, J., Meule, A., Honjo, K., Pourret, O., & 1,560 othersYin, C-C., Zhang, Z., Cascella, M., Flegel, W. A., Goodyear, C. S., van Raaij, M. J., Bukowy-Bieryllo, Z., Campana, L. G., Kurniawan, N. A., Lalaouna, D., Huttner, F. J., Ammerman, B. A., Ehret, F., Cobine, P. A., Tan, E-C., Han, H., Xia, W., McCrum, C., Dings, R. P. M., Marinello, F., Nilsson, H., Nixon, B., Voskarides, K., Yang, L., Costa, V. D., Bengtsson-Palme, J., Bradshaw, W., Grimm, D. G., Kumar, N., Martis, E., Prieto, D., Sabnis, S. C., Amer, S. E. D. R., Liew, A. W. C., Perco, P., Rahimi, F., Riva, G., Zhang, C., Devkota, H. P., Ogami, K., Basharat, Z., Fierz, W., Siebers, R., Tan, K-H., Boehme, K. A., Brenneisen, P., Brown, J. A. L., Dalrymple, B. P., Harvey, D. J., Ng, G., Werten, S., Bleackley, M., Dai, Z., Dhariwal, R., Gelfer, Y., Hartmann, M. D., Miotla, P., Tamaian, R., Govender, P., Gurney-Champion, O. J., Kauppila, J. H., Zhang, X., Echeverria, N., Subhash, S., Sallmon, H., Tofani, M., Bae, T., Bosch, O., Cuiv, P. O., Danchin, A., Diouf, B., Eerola, T., Evangelou, E., Filipp, F. V., Klump, H., Kurgan, L., Smith, S. S., Terrier, O., Tuttle, N., Ascher, D. B., Janga, S. C., Schulte, L. N., Becker, D., Browngardt, C., Bush, S. J., Gaullier, G., Ide, K., Meseko, C., Werner, G. D. A., Zaucha, J., Al-Farha, A. A., Greenwald, N. F., Popoola, S. I., Rahman, M. S., Xu, J., Yang, S. Y., Hiroi, N., Alper, O. M., Baker, C. I., Bitzer, M., Chacko, G., Debrabant, B., Dixon, R., Forano, E., Gilliham, M., Kelly, S., Klempnauer, K-H., Lidbury, B. A., Lin, M. Z., Lynch, I., Ma, W., Maibach, E. W., Mather, D. E., Nandakumar, K. S., Ohgami, R. S., Parchi, P., Tressoldi, P., Xue, Y., Armitage, C., Barraud, P., Chatzitheochari, S., Coelho, L. P., Diao, J., Doxey, A. C., Gobet, A., Hu, P., Kaiser, S., Mitchell, K. M., Salama, M. F., Shabalin, I. G., Song, H., Stevanovic, D., Yadollahpour, A., Zeng, E., Zinke, K., Alimba, C. G., Beyene, T. J., Cao, Z., Chan, S. S., Gatchell, M., Kleppe, A., Piotrowski, M., Torga, G., Woldesemayat, A. A., Cosacak, M. I., Haston, S., Ross, S. A., Williams, R., Wong, A., Abramowitz, M. K., Effiong, A., Lee, S., Abid, M. B., Agarabi, C., Alaux, C., Albrecht, D. R., Atkins, G. J., Beck, C. R., Bonvin, A. M. J. J., Bourke, E., Brand, T., Braun, R. J., Bull, J. A., Cardoso, P., Carter, D., Delahay, R. M., Ducommun, B., Duijf, P. H. G., Epp, T., Eskelinen, E-L., Fallah, M., Farber, D. B., Fernandez-Triana, J., Feyerabend, F., Florio, T., Friebe, M., Furuta, S., Gabrielsen, M., Gruber, J., Grybos, M., Han, Q., Heinrich, M., Helantera, H., Huber, M., Jeltsch, A., Jiang, F., Josse, C., Jurman, G., Kamiya, H., de Keersmaecker, K., Kristiansson, E., de Leeuw, F-E., Li, J., Liang, S., Lopez-Escamez, J. A., Lopez-Ruiz, F. J., Marchbank, K. J., Marschalek, R., Martin, C. S., Miele, A. E., Montagutelli, X., Morcillo, E., Nicoletti, R., Niehof, M., O'Toole, R., Ohtomo, T., Oster, H., Palma, J-A., Paterson, R., Peifer, M., Portilla, M., Portillo, M. C., Pritchard, A. L., Pusch, S., Raghava, G. P. S., Roberts, N. J., Ross, K., Schuele, B., Sergeant, K., Shen, J., Stella, A., Sukocheva, O., Uversky, V. N., Vanneste, S., Villet, M. H., Viveiros, M., Vorholt, J. A., Weinstock, C., Yamato, M., Zabetakis, I., Zhao, X., Ziegler, A., Aizat, W. M., Atlas, L., Bridges, K. M., Chakraborty, S., Deschodt, M., Domingues, H. S., Esfahlani, S. S., Falk, S., Guisado, J. L., Kane, N. C., Kueberuwa, G., Lau, C. L., Liang, D., Liu, E., Luu, A. M., Ma, C., Ma, L., Moyer, R., Norris, A. D., Panthee, S., Parsons, J. R., Peng, Y., Pinto, I. M., Reschke, C. R., Sillanpaa, E., Stewart, C. J., Uhle, F., Yang, H., Zhou, K., Zhu, S., Ashry, M., Bergsland, N., Berthold, M., Chen, C-E., Colella, V., Cuypers, M., Eskew, E. A., Fan, X., Gajda, M., Gonzalezlez-Prendes, R., Goodin, A., Graham, E. B., Groen, E. J. N., Gutierrez-Sacristan, A., Habes, M., Heffler, E., Higginbottom, D. B., Janzen, T., Jayaraman, J., Jibb, L. A., Jongen, S., Kinyanjui, T., Koleva-Kolarova, R. G., Li, Z., Liu, Y-P., Lund, B. A., Lussier, A. A., Ma, L., Mier, P., Moore, M. D., Nagler, K., Orme, M. W., Pearson, J. A., Prajapati, A. S., Saito, Y., Troder, S. E., Uchendu, F., Verloh, N., Voutchkova, D. D., Abu-Zaid, A., Bakkach, J., Baumert, P., Dono, M., Hanson, J., Herbelet, S., Hobbs, E., Kulkarni, A., Kumar, N., Liu, S., Loft, N. D., Reddan, T., Senghore, T., Vindin, H., Xu, H., Bannon, R., Chen, B., Cheung, J. T. K., Cooper, J., Esnakul, A. K., Feghali, K. A., Ghelardi, E., Gnasso, A., Horbar, J., Lai, H. M., Li, J., Ma, L., Ma, R., Pan, Z., Peres, M. A., Pranata, R., Seow, E., Sydes, M., Testoni, I., Westermair, A. L., Yang, Y., Afnan, M., Albiol, J., Albuquerque, L. G., Amiya, E., Amorim, R. M., An, Q., Andersen, S. U., Aplin, J. D., Argyropoulos, C., Asmann, Y. W., Assaeed, A. M., Atanasov, A. G., Atchison, D. A., Avery, S. V., Avillach, P., Baade, P. D., Backman, L., Badie, C., Baldi, A., Ball, E., Bardot, O., Barnett, A. G., Basner, M., Batra, J., Bazanova, O. M., Beale, A., Beddoe, T., Bell, M. L., Berezikov, E., Berners-Price, S., Bernhardt, P., Berry, E., Bessa, T. B., Billington, C., Birch, J., Blakely, R. D., Blaskovich, M. A. T., Blum, R., Boelaert, M., Bogdanos, D., Bosch, C., Bourgoin, T., Bouvard, D., Boykin, L. M., Bradley, G., Braun, D., Brownlie, J., Bruhl, A., Burt, A., Butler, L. M., Byrareddy, S. N., Byrne, H. J., Cabantous, S., Calatayud, S., Candal, E., Carlson, K., Casillas, S., Castelvetro, V., Caswell, P. T., Cavalli, G., Cerovsky, V., Chagoyen, M., Chen, C-S., Chen, D. F., Chen, H., Chen, H., Chen, J-T., Chen, Y., Cheng, C., Cheng, J., Chinapaw, M., Chinopoulos, C., Cho, W. C. S., Chong, L., Chowdhury, D., Chwalibog, A., Ciresi, A., Cockcroft, S., Conesa, A., Cook, P. A., Cooper, D. N., Coqueret, O., Corea, E. M., Costa, E., Coupland, C., Crawford, S. Y., Cruz, A. D., Cui, H., Cui, Q., Culver, D. C., D'Angiulli, A., Dahms, T. E. S., Daigle, F., Dalgleish, R., Danielsen, H. E., Darras, S., Davidson, S. M., Day, D. A., Degirmenci, V., Demaison, L., Devriendt, K., Ding, J., Dogan, Y., Dong, X. C., Donner, C. F., Dressick, W., Drevon, C. A., Duan, H., Ducho, C., Dumaz, N., Dwarakanath, B. S., Ebell, M. H., Eisenhardt, S., Elkum, N., Engel, N., Erickson, T. B., Fairhead, M., Faville, M. J., Fejzo, M. S., Festa, F., Feteira, A., Flood-Page, P., Forsayeth, J., Fox, S. A., Franks, S. J., Frentiu, F. D., Frilander, M. J., Fu, X., Fujita, S., Galea, I., Galluzzi, L., Gani, F., Ganpule, A. P., Garcia-Alix, A., Gedye, K., Giordano, M., Giunta, C., Gleeson, P. A., Goarant, C., Gong, H., Gora, D., Gough, M. J., Goyal, R., Graham, K. E., Grande-Perez, A., Graves, P. M., Greidanus, H., Grice, D., Grunau, C., Gumulya, Y., Guo, Y., Gurevich, V. V., Gusev, O., Hacker, E., Hage, S. R., Hagen, G., Hahn, S., Haller, D. M., Hammerschmidt, S., Han, J., Han, R., Handfield, M., Hapuarachchi, H. C., Harder, T., Hardingham, J. E., Heck, M., Heers, M., Hew, K. F., Higuchi, Y., St Hilaire, C., Hilton, R., Hodzic, E., Hone, A., Hongoh, Y., Hu, G., Huber, H. P., Hueso, L. E., Huirne, J., Hurt, L., Idborg, H., Ikeo, K., Ingley, E., Jakeman, P. M., Jensen, A., Jia, H., Jia, H., Jia, S., Jiang, J., Jiang, X., Jin, Y., Jo, D., Johnson, A. M., Johnston, M., Jonscher, K. R., Jorens, P. G., Jorgensen, J. O. L., Joubert, J. W., Jung, S-H., Junior, A. M., Kahan, T., Kamboj, S. K., Kang, Y-K., Karamanos, Y., Karp, N. A., Kelly, R., Kenna, R., Kennedy, J., Kersten, B., Khalaf, R. A., Khalid, J. M., Khatlani, T., Khider, T., Kijanka, G. S., King, S. R. B., Kluz, T., Knox, P., Kobayashi, T., Koch, K-W., Kohonen-Corish, M. R. J., Kong, X., Konkle-Parker, D., Korpela, K. M., Kostrikis, L. G., Kraiczy, P., Kratz, H., Krause, G., Krebsbach, P. H., Kristensen, S. R., Kumari, P., Kunimatsu, A., Kurdak, H., Kwon, Y. D., Lachat, C., Lagisz, M., Laky, B., Lammerding, J., Lange, M., Larrosa, M., Laslett, A. L., LeClair, E. E., Lee, K-W., Lee, M-Y., Lee, M-S., Li, G., Li, J., Lieb, K., Lim, Y. Y., Lindsey, M. L., Line, P-D., Liu, D., Liu, F., Liu, H., Liu, H., Lloyd, V. K., Lo, T-W., Locci, E., Loidl, J., Lorenzen, J., Lorkowski, S., Lovell, N. H., Lu, H., Lu, W., Lu, Z., Luengo, G. S., Lundh, L-G., Lysy, P. A., Mabb, A., Mack, H. G., Mackey, D. A., Mahdavi, S. R., Maher, P., Maher, T., Maity, S. N., Malgrange, B., Mamoulakis, C., Mangoni, A. A., Manke, T., Manstead, A. S. R., Mantalaris, A., Marsal, J., Marschall, H-U., Martin, F. L., Martinez-Raga, J., Martinez-Salas, E., Mathieu, D., Matsui, Y., Maza, E., McCutcheon, J. E., Mckay, G. J., McMillan, B., McMillan, N., Meads, C., Medina, L., Merrick, B. A., Metzger, D. W., Meunier, F. A., Michaelis, M., Micheau, O., Mihara, H., Mintz, E. M., Mizukami, T., Moalic, Y., Mohapatra, D. P., Monteiro, A., Montes, M., Moran, J. V., Morozov, S. Y., Mort, M., Murai, N., Murphy, D. J., Murphy, S. K., Murray, S. A., Naganawa, S., Nammi, S., Nasios, G., Natoli, R. M., Nguyen, F., Nicol, C., van Nieuwerburgh, F., Nilsen, E. B., Nobile, C. J., O'Mahony, M., Ohlsson, S., Olatunbosun, O., Olofsson, P., Ortiz, A., Ostrikov, K., Otto, S., Outeiro, T. F., Ouyang, S., Paganoni, S., Page, A., Palm, C., Paradies, Y., Parsons, M. H., Parsons, N., Pascal, P., Paul, E., Peckham, M., Pedemonte, N., Pellizzon, M. A., Petrelli, M., Pichugin, A., Pinto, C. J. C., Plevris, J. N., Pollesello, P., Polz, M., Ponti, G., Porcelli, P., Prince, M., Quinn, G. P., Quinn, T. J., Ramula, S., Rappsilber, J., Rehfeldt, F., Reiling, J. H., Remacle, C., Rezaei, M., Riddick, E. W., Ritter, U., Roach, N. W., Roberts, D. D., Robles, G., Rodrigues, T., Rodriguez, C., Roislien, J., Roobol, M. J., Rowe, J. A., Ruepp, A., van Ruitenbeek, J., Rust, P., Saad, S., Sack, G. H., Santos, M., Saudemont, A., Sava, G., Schrading, S., Schramm, A., Schreiber, M., Schuler, S., Schymkowitz, J., Sczyrba, A., Seib, K. L., Shi, H-P., Shimada, T., Shin, J-S., Shortt, C., Silveyra, P., Skinner, D., Small, I., Smeets, P. A. M., So, P-W., Solano, F., Sonenshine, D. E., Song, J., Southall, T., Speakman, J. R., Srinivasan, M. V., Stabile, L. P., Stasiak, A., Steadman, K. J., Stein, N., Stephens, A. W., Stewart, D. I., Stine, K., Storlazzi, C., Stoynova, N. V., Strzalka, W., Suarez, O. M., Sultana, T., Sumant, A. V., Summers, M. J., Sun, G., Tacon, P., Tanaka, K., Tang, H., Tanino, Y., Targett-Adams, P., Tayebi, M., Tayyem, R., Tebbe, C. C., Telfer, E. E., Tempel, W., Teodorczyk-Injeyan, J. A., Thijs, G., Thorne, S., Thrift, A. G., Tiffon, C., Tinnefeld, P., Tjahjono, D. H., Tolle, F., Toth, E., del Tredici, A. L., Tsapas, A., Tsirigotis, K., Turak, A., Tzotzos, G., Udo, E. E., Utsumi, T., Vaidyanathan, S., Vaillant, M., Valsesia, A., Vandenbroucke, R. E., Veiga, F. H., Vendrell, M., Vesk, P. A., Vickers, P., Victor, V. M., Villemur, R., Vohl, M-C., Voolstra, C. R., Vuillemin, A., Wakelin, S., Waldron, L., Walsh, L. J., Wang, A. Y., Wang, F., Wang, Y., Watanabe, Y., Weigert, A., Wen, J-C., Wham, C., White, E. P., Wiener, J., Wilharm, G., Wilkinson, S., Willmann, R., Wilson, C., Wirth, B., Wojan, T. R., Wolff, M., Wong, B. M., Wu, T-W., Wuerbel, H., Xiao, X., Xu, D., Xu, J. W., Xu, J., Xue, B., Yalcin, S., Yan, H., Yang, E-C., Yang, S., Yang, W., Ye, Y., Ye, Z-Q., Yli-Kauhaluoma, J., Yoneyama, H., Yu, Y., Yuan, G-C., Yuh, C-H., Zaccolo, M., Zeng, C., Zevnik, B., Zhang, C., Zhang, L., Zhang, L., Zhang, Y., Zhang, Y., Zhang, Z., Zhang, Z-Y., Zhao, Y., Zhou, M., Zuberbier, T., Aanei, C. M., Ahmad, R., Al-Lawama, M., Alanio, A., Allardyce, J., Alonso-Caneiro, D., Atack, J. M., Baier, D., Bansal, A., Benezeth, Y., Berbesque, C., Berrevoet, F., Biedermann, P. H. W., Bijleveld, E., Bittner, F., Blombach, F., Van den Bos, W., Boudreau, S. A., Bramoweth, A. D., Braubach, O., Cai, Y., Campbell, M., Cao, Z., Catry, T., Chen, X., Cheng, S., Chung, H-J., Chavez-Fumagalli, M. A., Conway, A., Costa, B. M., Cyr, N., Dean, L. T., Denzel, M. S., Dlamini, S. V., Dudley, K. J., Dufies, M., Ecke, T., Eckweiler, D., Eixarch, E., El-Adawy, H., Emmrich, J. V., Eustace, A. J., Falter-Wagner, C. M., Fuss, J., Gao, J., Gill, M. R., Gloyn, L., Goggs, R., Govinden, U., Greene, G., Greiff, V., Grundle, D. S., Gruneberg, P., Gumede, N., Haore, G., Harrison, P., Hoenner, X., Hojsgaard, D., Hori, H., Ikonomopoulou, M. P., Jeurissen, P., Johnson, D. M., Kabra, D., Kamagata, K., Karmakar, C., Kasian, O., Kaye, L. K., Khan, M. M., Kim, Y-M., Kish, J. K., Kobold, S., Kohanbash, G., Kohls, G., Kugler, J-M., Kumar, G., Lacy-Colson, J., Latif, A., Lauschke, V. M., Li, B., Lim, C. 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I., Park, S., Patil, C. D., Pedro, S. A., Perry, S. R., Peter, J., Peterson, B. M., Pezzuolo, A., Pozdnyakov, I., Qian, S., Qin, L., Rafe, A., Raote, I., Raza, A., Rebl, H., Refai, O., Regan, T., Richa, T., Richardson, M. F., Robinson, K. R., Rossoni, L., Rouet, R., Safaei, S., Schneeberger, P. H. H., Schwotzer, D., Sebastian, A., Selinski, J., Seltmann, S., Sha, F., Shalev, N., Shang, J-L., Singer, J., Singh, M., Smith, T., Solomon-Moore, E., Song, L., Soraggi, S., Stanley, R., Steckhan, N., Strobl, F., Subissi, L., Supriyanto, I., Surve, C. R., Suzuki, T., Syme, C., Sorelius, K., Tang, Y., Tantawy, M., Tennakoon, S., Teseo, S., Toelzer, C., Tomov, N., Tovar, M., Tran, L., Tripathi, S., Tuladhar, A. M., Ukubuiwe, A. C., Ung, C. O. L., Valgepea, K., Vatanparast, H., Vidal, A., Wang, F., Wang, Q., Watari, R., Webster, R., Webster, R., Wei, J., Wibowo, D., Wingenbach, T. S. H., Xavier, R. M., Xiao, S., Xiong, P., Xu, S., Xu, S., Yao, R., Yao, W., Yin, Q., Yu, Y., Zaitsu, M., Zeineb, Z., Zhan, X-Y., Zhang, J., Zhang, R., Zhang, W., Zhang, X., Zheng, S., Zhou, B., Zhou, X., Ahmad, H., Akinwumi, S. A., Albery, G. F., Alhowimel, A., Ali, J., Alshehri, M., Alsuhaibani, M., Anikin, A., Azubuike, S. O., Bach-Mortensen, A., Baltiansky, L., Bartas, M., Belachew, K. Y., Bhardwaj, V., Binder, K., Bland, N. S., Boah, M., Bullen, B., Calabro, G. E., Callahan, T. J., Cao, B., Chalmers, K., Chang, W., Che, Z., Chen, A. T. Y., Chen, H., Chen, H., Chen, Y., Chen, Z., Choi, Y., Chowdhury, M. A. K., Christensen, M. R., Cooke, R. S. C., Cottini, M., Covington, N. V., Cunningham, C., Delarocque, J., Devos, L., Dhar, A. R., Ding, K-F., Dong, K., Dong, Z., Dreyer, N., Ekstrand, C., Fardet, T., Feleke, B. E., Feurer, T., Freitas, A., Gao, T., Asefa, N. G., Giganti, F., Grabowski, P., Guerra-Mora, J. 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L., Schmidt, A., Schurr, R., Searles, S., Sharma, S., Sheehan, B., Shi, C., Shohayeb, B., Sommerlad, A., Strehlow, J., Sun, X., Sundar, R., Taherzadeh, G., Tahir, N. D. M., Tang, J., Testa, J., Tian, Z., Tingting, Q., Verheijen, G. P., Vickstrom, C., Wang, T., Wang, X., Wang, Z., Wei, P., Wilson, A., Wyart, Yassine, A-A., Yousefzadeh, A., Zare, A., Zeng, Z., Zhang, C., Zhang, H., Zhang, L., Zhang, T., Zhang, W., Zhang, Z., Zhou, J., Zhu, D., Adamo, V., Adeyemo, A. A., Aggelidou, M., Al-Owaifeer, A. M., Al-Riyami, A. Z., Alzghari, S. K., Andersen, V., Angus, K., Asaduzzaman, M., Asady, H., Ato, D., Bai, X., Baines, R. L., Ballantyne, M., Ban, B., Beck, J., Ben-Nafa, W., Black, E., Blancher, A., Blankstein, R., Bodagh, N., Borges, P. A. V., Brooks, A., Brox-Ponce, J., Brunetti, A., Canham, C. D., Carninci, P., Carvajal, R., Chang, S. C., Chao, J., Chatterjee, P., Chen, H., Chen, Y-C., Chhatriwalla, A. K., Chikowe, I., Chuang, T-J., Collevatti, R. G., Valera-Cornejo, D. A., Cuenda, A., Dao, M., Dauga, D., Deng, Z., Devkota, K., Doan, L. V., Elewa, Y. H. A., Fan, D., Faruk, M., Feifei, S., Ferguson, T. S., Fleres, F., Foster, E. J., Foster, C. S., Furer, T., Gao, Y., Garcia-Rivera, E. J., Gazdar, A., George, R. B., Ghosh, S., Gianchecchi, E., Gleason, J. M., Hackshaw, A., Hall, A., Hall, R., Harper, P., Hogg, W. E., Huang, G., Hunter, K. E., IJzerman, A. P., Jesus, C., Jian, G., Lewis, J. S. . J., Kanj, S. S., Kaur, H., Kelly, S., Kheir, F., Kichatova, V. S., Kiyani, M., Klein, R., Kovesi, T., Kraschnewski, J. L., Kumar, A. P., Labutin, D., Lazo-Langner, A., Leclercq, G., Li, M., Li, Q., Li, T., Li, Y., Liao, W-T., Liao, Z., Lin, J., Lizer, J., Lobreglio, G., Lowies, C., Lu, C., Majeed, H., Martin, A., Martinez-Sobrido, L., Meresh, E., Middelveen, M., Mohebbi, A., Mota, J., Mozaheb, Z., Muyaya, L., Nandhakumar, A., Ng, S. H. X., Obeidat, M., Oh, D-H., Owais, M., Pace-Asciak, P., Panwar, A., Park, C., Patterson, C., Penagos-Tabaree, F., Pianosi, P. T., Pinzi, V., Pridans, C., Psaroulaki, A., Pujala, R. K., Pulido-Arjona, L., Qi, P-F., Rahman, P., Rai, N. K., Rassaf, T., Refardt, J., Ricciardi, W., Riess, O., Rovas, A., Sacks, F. M., Saleh, S., Sampson, C., Schmutz, A., Sepanski, R., Sharma, N., Singh, M., Spearman, P., Subramaniapillai, M., Swali, R., Tan, C. M., Tellechea, J. I., Thomas, L-M., Tong, X., Veys, R., Vitriol, V., Wang, H-D., Wang, J., Wang, J., Waugh, J., Webb, S. A., Williams, B. A., Workman, A. D., Xiang, T., Xie, L-X., Xu, J., Xu, T., Yang, C., Yoon, J. G., Yuan, C. M., Zaritsky, A., Zhang, Y., Zhao, H., Zuckerman, H., Lyu, R., Pullan, W. & Zhou, Y., 29 Oct 2019, In: DATABASE-THE JOURNAL OF BIOLOGICAL DATABASES AND CURATION. 2019, p. 1-66 66 p.

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    23 Citations (Scopus)

  • Nuclear localization and phosphorylation modulate pathological effects of Alpha-Synuclein

    Pinho, R., Paiva, I., Jercic, K. G., Fonseca-Ornelas, L., Gerhardt, E., Fahlbusch, C., Garcia-Esparcia, P., Kerimoglu, C., Pavlou, M. A., Villar-Piqué, A., Szego, É., Fonseca, T. L., Odoardi, F., Soeroes, S., Rego, A. C., Fischle, W., Schwamborn, J. C., Meyer, T., Kügler, S., Ferrer, I., & 6 othersAttems, J., Fischer, A., Becker, S., Zweckstetter, M., Borovecki, F. & Outeiro, T. F., 1 Jan 2019, In: Human molecular genetics. 28, 1, p. 31-50 10 p.

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    133 Citations (Scopus)

  • The synthetic cannabinoid JWH-018 modulates Saccharomyces cerevisiae energetic metabolism

    Ferreira, C., Couceiro, J., Família, C., Jardim, C., Antas, P., Santos, C. N., Outeiro, T. F., Tenreiro, S. & Quintas, A., 8 Aug 2019, In: FEMS Yeast Research. 19, 5, foz042.

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    2 Citations (Scopus)

  • Threonine 3 regulates Serine 13/16 phosphorylation in the huntingtin exon 1

    Herrera, F., Branco-santos, J. & Outeiro, T., 24 May 2019, In: Matters Select.

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  • α-Synuclein toxicity in yeast and human cells is caused by cell cycle re-entry and autophagy degradation of ribonucleotide reductase 1

    Sampaio-Marques, B., Guedes, A., Vasilevskiy, I., Gonçalves, S., Outeiro, T. F., Winderickx, J., Burhans, W. C. & Ludovico, P., 1 Aug 2019, In: Aging cell. 18, 4, e12922.

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  • 2018

    (Poly)phenol-digested metabolites modulate alpha-synuclein toxicity by regulating proteostasis

    Macedo, D., Jardim, C., Figueira, I., Almeida, A. F., McDougall, G. J., Stewart, D., Yuste, J. E., Tomás-Barberán, F. A., Tenreiro, S., Outeiro, T. F. & Santos, C. N., 3 May 2018, In: Scientific Reports. 8, 1, 6965.

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  • Alpha-synuclein deregulates the expression of COL4A2 and impairs ER-Golgi function

    Paiva, I., Jain, G., Lázaro, D. F., Jerčić, K. G., Hentrich, T., Kerimoglu, C., Pinho, R., Szegő, È. M., Burkhardt, S., Capece, V., Halder, R., Islam, R., Xylaki, M., Caldi Gomes, L. A., Roser, A. E., Lingor, P., Schulze-Hentrich, J. M., Borovečki, F., Fischer, A. & Outeiro, T. F., 1 Nov 2018, In: Neurobiology of Disease. 119, p. 121-135 15 p.

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    45 Citations (Scopus)

  • Identification of novel protein phosphatases as modifiers of alpha-synuclein aggregation in yeast

    Brás, I. C., Tenreiro, S., Silva, A. M. & Outeiro, T. F., 1 Dec 2018, In: FEMS Yeast Research. 18, 8

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    3 Citations (Scopus)

  • Sensing α-Synuclein From the Outside via the Prion Protein: Implications for Neurodegeneration

    Brás, I. C., Lopes, L. V. & Outeiro, T. F., 1 Nov 2018, In: Movement Disorders. 33, 11, p. 1675-1684 10 p.

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    16 Citations (Scopus)
  • 2017

    Correction: The mechanism of sirtuin 2-mediated exacerbation of alpha-synuclein toxicity in models of Parkinson disease

    de Oliveira, R. M., Vicente Miranda, H., Francelle, L., Pinho, R., Szegö, É. M., Martinho, R., Munari, F., Lázaro, D. F., Moniot, S., Guerreiro, P., Fonseca-Ornelas, L., Marijanovic, Z., Antas, P., Gerhardt, E., Enguita, F. J., Fauvet, B., Penque, D., Pais, T. F., Tong, Q., Becker, S., & 5 othersKügler, S., Lashuel, H. A., Steegborn, C., Zweckstetter, M. & Outeiro, T. F., Apr 2017, In: PLoS Biology. 15, 4, p. e1002601

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  • Glycation potentiates α-synuclein-associated neurodegeneration in synucleinopathies

    Vicente Miranda, H., Szego, É. M., Oliveira, L. M. A., Breda, C., Darendelioglu, E., De Oliveira, R. M., Ferreira, D. G., Gomes, M. A., Rott, R., Oliveira, M., Munari, F., Enguita, F. J., Simões, T., Rodrigues, E. F., Heinrich, M., Martins, I. C., Zamolo, I., Riess, O., Cordeiro, C., Ponces-Freire, A., & 12 othersLashuel, H. A., Santos, N. C., Lopes, L. V., Xiang, W., Jovin, T. M., Penque, D., Engelender, S., Zweckstetter, M., Klucken, J., Giorgini, F., Quintas, A. & Outeiro, T. F., 1 May 2017, In: Brain. 140, 5, p. 1399-1419 21 p.

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    164 Citations (Scopus)

  • Mutant A53T α-Synuclein Improves Rotarod Performance Before Motor Deficits and Affects Metabolic Pathways

    Guerreiro, P. S., Coelho, J. E., Sousa-Lima, I., Macedo, M. P., Lopes, L. V., Outeiro, T. F. & Pais, T. F., 1 Mar 2017, In: NeuroMolecular Medicine. 19, 1, p. 1-9 9 p.

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    21 Citations (Scopus)

  • Phycocyanin protects against Alpha-Synuclein toxicity in yeast

    Macedo, D., Bertolin, T. E., Oro, T., Backes, L. T. H., Brás, I. C., Santos, C. N., Tenreiro, S. & Outeiro, T. F., 2017, In: Journal of Functional Foods. 38, p. 553-560 8 p.

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    13 Citations (Scopus)

  • Posttranslational modifications of blood-derived alpha-synuclein as biochemical markers for Parkinson's disease

    Miranda, H. V., Cássio, R., Correia-Guedes, L., Gomes, M. A., Chegão, A., Miranda, E., Soares, T., Coelho, M., Rosa, M. M., Ferreira, J. J. & Outeiro, T. F., 2017, In: Scientific Reports. 7, 1, p. Online 11 p., 13713.

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  • Sodium butyrate rescues dopaminergic cells from alpha-synuclein-induced transcriptional deregulation and DNA damage

    Paiva, I., Pinho, R., Pavlou, M. A., Hennion, M., Wales, P., Schütz, A. L., Rajput, A., Szego, É. M., Kerimoglu, C., Gerhardt, E., Rego, A. C., Fischer, A., Bonn, S. & Outeiro, T. F., 15 Jun 2017, In: Human molecular genetics. 26, 12, p. 2231-2246 16 p.

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    139 Citations (Scopus)

  • Synthesis and Biological Evaluation of Novel 2-Aryl Benzimidazoles as Chemotherapeutic Agents

    Morais, G. R., Palma, E., Marques, F., Gano, L., Oliveira, M. C., Abrunhosa, A., Miranda, H. V., Outeiro, T. F., Santos, I. & Paulo, A., Jan 2017, In: Journal Of Heterocyclic Chemistry. 54, 1, p. 255-267

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    22 Citations (Scopus)

  • The mechanism of sirtuin 2–mediated exacerbation of alpha-synuclein toxicity in models of Parkinson disease

    de Oliveira, R. M., Vicente Miranda, H., Francelle, L., Pinho, R., Szegö, É. M., Martinho, R., Munari, F., Lázaro, D. F., Moniot, S., Guerreiro, P., Fonseca, L., Marijanovic, Z., Antas, P., Gerhardt, E., Enguita, F. J., Fauvet, B., Penque, D., Pais, T. F., Tong, Q., Becker, S., & 5 othersKügler, S., Lashuel, H. A., Steegborn, C., Zweckstetter, M. & Outeiro, T. F., Mar 2017, In: PLoS Biology. 15, 3, p. Online 27 p.

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  • The NAD+-dependent deacetylase SIRT2 attenuates oxidative stress and mitochondrial dysfunction and improves insulin sensitivity in hepatocytes

    Lemos, V., de Oliveira, R. M., Naia, L., Szegö, É., Ramos, E., Pinho, S., Magro, F., Cavadas, C., Cristina Rego, A., Costa, V., Outeiro, T. F. & Gomes, P., 1 Nov 2017, In: Human molecular genetics. 26, 21, p. 4105-4117 13 p.

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  • Traffic jams and the complex role of α-Synuclein aggregation in Parkinson disease

    Gonçalves, S. A. & Outeiro, T. F., 3 Apr 2017, In: Small GTPases. p. 1-7 7 p.

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    12 Citations (Scopus)

  • α-synuclein interacts with PrP C to induce cognitive impairment through mGluR5 and NMDAR2B

    Ferreira, D. G., Temido-Ferreira, M., Miranda, H. V., Batalha, V. L., Coelho, J. E., Szegö, É. M., Marques-Morgado, I., Vaz, S. H., Rhee, J. S., Schmitz, M., Zerr, I., Lopes, L. V. & Outeiro, T. F., 1 Jan 2017, In: Nature Neuroscience. 20, 11, p. 1569-1579 11 p.

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    214 Citations (Scopus)
  • 2016

    A familial ATP13A2 mutation enhances alpha-synuclein aggregation and promotes cell death

    Lopes da Fonseca, T., Pinho, R. & Outeiro, T. F., 15 Jul 2016, In: Human molecular genetics. 25, 14, p. 2959-2971 13 p.

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    28 Citations (Scopus)

  • Analysis of Protein Oligomeric Species by Sucrose Gradients

    Tenreiro, S., Macedo, D., Marijanovic, Z. & Outeiro, T. F., 2016, In: Methods in Molecular Biology. 1449, p. 331-9 9 p.

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    1 Citation (Scopus)

  • A Novel Microfluidic Cell Co-culture Platform for the Study of the Molecular Mechanisms of Parkinson's Disease and Other Synucleinopathies

    Fernandes, J. T. S., Chutna, O., Chu, V., Conde, J. P. & Outeiro, T. F., 15 Nov 2016, In: Frontiers in Cellular Neuroscience. 10

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    46 Citations (Scopus)

  • Gene Expression Differences in Peripheral Blood of Parkinson's Disease Patients with Distinct Progression Profiles

    Pinho, R., Guedes, L. C., Soreq, L., Lobo, P. P., Mestre, T., Coelho, M., Rosa, M. M., Goncalves, N., Wales, P., Mendes, T., Gerhardt, E., Fahlbusch, C., Bonifati, V., Bonin, M., Miltenberger-Miltenyi, G., Borovecki, F., Soreq, H., Ferreira, J. J. & Outeiro, T. F., 20 Jun 2016, In: PLoS ONE. 11, 6, e0157852.

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    39 Citations (Scopus)
    49 Downloads (Pure)

  • Glycation in Parkinson's disease and Alzheimer's disease

    Vicente Miranda, H., El-Agnaf, O. M. A. & Outeiro, T. F., Jun 2016, In: Movement disorders : official journal of the Movement Disorder Society. 31, 6, p. 782-90 9 p.

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    113 Citations (Scopus)

  • Glycation potentiates neurodegeneration in models of Huntington's disease

    Miranda, H. V., Gomes, M. A., Branco-Santos, J., Breda, C., Lazaro, D. F., Lopes, L. V., Herrera, F., Giorgini, F. & Outeiro, T. F., 18 Nov 2016, In: Scientific Reports. 6

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    28 Citations (Scopus)
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  • shRNA-Based Screen Identifies Endocytic Recycling Pathway Components That Act as Genetic Modifiers of Alpha-Synuclein Aggregation, Secretion and Toxicity

    Goncalves, S. A., Macedo, D., Raquel, H., Simoes, P. D., Giorgini, F., Ramalho, J. S., Barral, D. C., Moita, L. F. & Outeiro, T. F., Apr 2016, In: PLoS Genetics. 12, 4, 26 p., e1005995.

    Research output: Contribution to journal › Article › peer-review

    67 Citations (Scopus)

  • The caffeine-binding adenosine A(2A) receptor induces age-like HPA-axis dysfunction by targeting glucocorticoid receptor function

    Batalha, V. L., Ferreira, D. G., Coelho, J. E., Valadas, J. S., Gomes, R., Temido-Ferreira, M., Shmidt, T., Baqi, Y., Buee, L., Mueller, C. E., Hamdane, M., Outeiro, T. F., Bader, M., Meijsing, S. H., Sadri-Vakili, G., Blum, D. & Lopes, L. V., 11 Aug 2016, In: Scientific Reports. 6, 31493, 31493.

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    55 Citations (Scopus)
    33 Downloads (Pure)

  • The effects of the novel A53E alpha-synuclein mutation on its oligomerization and aggregation

    Lázaro, D. F., Dias, M. C., Carija, A., Navarro, S., Madaleno, C. S., Tenreiro, S., Ventura, S. & Outeiro, T. F., 9 Dec 2016, In: Acta neuropathologica communications. 4, 1, p. 128-143 15 p.

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    32 Citations (Scopus)
    33 Downloads (Pure)

  • Yeast reveals similar molecular mechanisms underlying alpha- and beta-synuclein toxicity

    Tenreiro, S., Rosado-Ramos, R., Gerhardt, E., Favretto, F., Magalhães, F., Popova, B., Becker, S., Zweckstetter, M., Braus, G. H. & Outeiro, T. F., 15 Jan 2016, In: Human molecular genetics. 25, 2, p. 275-90 16 p.

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    28 Citations (Scopus)

  • αB-Crystallin overexpression in astrocytes modulates the phenotype of the BACHD mouse model of Huntington's disease

    Oliveira, A. O., Osmand, A., Outeiro, T. F., Muchowski, P. J. & Finkbeiner, S., 1 May 2016, In: Human molecular genetics. 25, 9, p. 1677-1689 13 p., ddw028.

    Research output: Contribution to journal › Article › peer-review

    34 Citations (Scopus)
  • 2015

    Emerging role of Sirtuin 2 in the regulation of mammalian metabolism

    Gomes, P., Outeiro, T. F. & Cavadas, C., Nov 2015, In: Trends In Pharmacological Sciences. 36, 11, p. 756-768

    Research output: Contribution to journal › Article › peer-review

    210 Citations (Scopus)

  • Isostructural Re(I)/Tc-99m(I) tricarbonyl complexes for cancer theranostics

    Nunes, P., Morais, G. R., Palma, E., Silva, F., Oliveira, M. C., Ferreira, V. F. C., Mendes, F., Gano, L., Vicente Miranda, H., Outeiro, T. F., Santos, I. & Paulo, A., 2015, In: Organic & Biomolecular Chemistry. 13, 18, p. 5182-5194 13 p.

    Research output: Contribution to journal › Article › peer-review

    19 Citations (Scopus)
  • 2014

    The small GTPase Rab11 co-localizes with α-synuclein in intracellular inclusions and modulates its aggregation, secretion and toxicity

    Chutna, O., Gonçalves, S., Villar-Piqué, A., Guerreiro, P., Marijanovic, Z., Mendes, T., Ramalho, J., Emmanouilidou, E., Ventura, S., Klucken, J., Barral, D. C., Giorgini, F., Vekrellis, K. & Outeiro, T. F., 20 Dec 2014, In: Human molecular genetics. 23, 25, p. 6732-6745 14 p.

    Research output: Contribution to journal › Article › peer-review

    73 Citations (Scopus)
  • 2011

    Assessment of the Efficacy of Solutes from Extremophiles on Protein Aggregation in Cell Models of Huntington's and Parkinson's Diseases

    Jorge, C. D., Ventura, M. R., Maycock, C. D., Outeiro, T. F., Santos, M. H. & Costa, J. C., 1 Jan 2011, In: Neurochemical Research. 36, 6, p. 1005-1011

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    Open Access
    6 Citations (Scopus)
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