• 929 Citations
  • 17 h-Index
20042019

Research output per year

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Research Output at NOVA

2019

Aldehyde Oxidases as Enzymes in Phase I Drug Metabolism

Mota, C., Santos-Silva, T. S., Terao, M., Garattini, E., Romão, M. J. & Leimkühler, S., 27 Jun 2019, Pharmaceutical Biocatalysis: Fundamentals, Enzyme Inhibitors, and Enzymes in Health and Diseases. Grunwald, P. (ed.). Routledge Taylor & Francis Group, 27 p.

Research output: Chapter in Book/Report/Conference proceedingChapter

1 Citation (Scopus)

Human aldehyde oxidase (hAOX1): structure determination of the Moco-free form of the natural variant G1269R and biophysical studies of single nucleotide polymorphisms

Mota, C., Esmaeeli, M., Coelho, C., Santos-Silva, T., Wolff, M., Foti, A., Leimkühler, S. & Romão, M. J., 1 May 2019, In : FEBS Open Bio. 9, 5, p. 925-934 10 p.

Research output: Contribution to journalArticle

Open Access
File
3 Citations (Scopus)
4 Downloads (Pure)
Open Access
File
1 Citation (Scopus)
Open Access
2018

Binding of vanadium to human serum transferrin - voltammetric and spectrometric studies

Azevedo, C. G., dos Santos, M. M. C., Santos, M. F. A., Santos-Silva, T., Doutch, J., Fernandes, L., Santos, H. M., Capelo, J. L., Pessoa, J. C. & Correia, I., 1 Mar 2018, In : Journal of Inorganic Biochemistry. 180, p. 211-221 11 p.

Research output: Contribution to journalArticle

11 Citations (Scopus)

Critical overview on the structure and metabolism of human aldehyde oxidase and its role in pharmacokinetics

Mota, C., Coelho, C., Leimkühler, S., Garattini, E., Terao, M., Santos-Silva, T. & Romão, M. J., 1 Aug 2018, In : Coordination Chemistry Reviews. 368, p. 35-59 25 p.

Research output: Contribution to journalReview article

8 Citations (Scopus)
Open Access
File
7 Citations (Scopus)
25 Downloads (Pure)
3 Citations (Scopus)

Optical and Structural Characterization of a Chronic Myeloid Leukemia DNA Biosensor

Cordeiro, M., Otrelo-Cardoso, A. R. C., Svergun, D. I., Konarev, P. V., Lima, J. C., Santos-Silva, T. & Baptista, P. V., 18 May 2018, In : ACS Chemical Biology. 13, 5, p. 1235-1242 8 p.

Research output: Contribution to journalArticle

Open Access
1 Citation (Scopus)

Structural elucidation of macromolecules

Romão, M. J., Santos-Silva, T. S., Carvalho, A. L., Cabrita, E. J. & Marcelo, F. M. B. M., 2018, Essential Techniques for Medical and Life Scientists : A Guide to Contemporary Methods and Current Applications With the Protocols. Bentham Science Publishers Ltd., Vol. Pt.1. p. 30-91 61 p.

Research output: Chapter in Book/Report/Conference proceedingChapter

2017

Electron transfer through arsenite oxidase: Insights into Rieske interaction with cytochrome c

Watson, C., Niks, D., Hille, R., Vieira, M., Schoepp-Cothenet, B., Marques, A. T., Romão, M. J., Santos-Silva, T. & Santini, J. M., 1 Oct 2017, In : Biochimica et Biophysica Acta - Bioenergetics. 1858, 10, p. 865-872 8 p.

Research output: Contribution to journalArticle

3 Citations (Scopus)

Highly selective tungstate transporter protein TupA from Desulfovibrio alaskensis G20

Otrelo-Cardoso, A. R., Nair, R. R., Correia, M. A. S., Cordeiro, R. S. C., Panjkovich, A., Svergun, D. I., Santos-Silva, T. & Rivas, M. G., 1 Dec 2017, In : Scientific Reports. 7, 1, 5798.

Research output: Contribution to journalArticle

Open Access
3 Citations (Scopus)

Interaction of [VIVO(acac)2] with Human Serum Transferrin and Albumin

Chorna, I., Cavaco, I., Roy, S., Kuznetsov, M. L., Ribeiro, N., Justino, G., Marques, F., Santos-Silva, T., Santos, M. F. A., Santos, H. M., Capelo, J. L., Doutch, J. & Pessoa, J. C., 17 Aug 2017, In : Chemistry - An Asian Journal. 12, 16, p. 2062-2084 23 p.

Research output: Contribution to journalArticle

22 Citations (Scopus)

Structural basis for the role of mammalian aldehyde oxidases in the metabolism of drugs and xenobiotics

Romão, M. J., Coelho, C., Santos-Silva, T., Foti, A., Terao, M., Garattini, E. & Leimkühler, S., 1 Apr 2017, In : Current Opinion in Chemical Biology. 37, p. 39-47 9 p.

Research output: Contribution to journalReview article

11 Citations (Scopus)
2016

In vitro and in vivo biological characterization of the anti-proliferative potential of a cyclic trinuclear organotin(IV) complex

Martins, M., Baptista, PV., Mendo, A. S., Correia, C., Videira, P., Rodrigues, AS., Muthukumaran, J., Santos-Silva, T., Silva, A., Guedes da Silva, M. F. C., Gigante, J., Duarte, A., Gajewska, M. & Fernandes, AR., 2016, In : Molecular Biosystems. 12, 3, p. 1015-1023 9 p.

Research output: Contribution to journalArticle

15 Citations (Scopus)

Optimization of the expression of human aldehyde oxidase for investigations of single-nucleotide polymorphisms

Foti, A., Hartmann, T., Coelho, C. M. C., Santos-Silva, T., Romão, M. J. & Leimkühler, S., 1 Aug 2016, In : Drug Metabolism And Disposition. 44, 8, p. 1277-1285 9 p.

Research output: Contribution to journalArticle

17 Citations (Scopus)

Structure and function of mammalian aldehyde oxidases

Terao, M., Romao, M. J., Leimkuehler, S., Bolis, M., Fratelli, M., Coelho, C. M. C., Santos-Silva, T. S. & Garattini, E., Apr 2016, In : Archives Of Toxicology. 90, 4, p. 753-780 28 p.

Research output: Contribution to journalLiterature review

Open Access
41 Citations (Scopus)

The Escherichia coli Periplasmic Aldehyde Oxidoreductase Is an Exceptional Member of the Xanthine Oxidase Family of Molybdoenzymes

Correia, M. A. S., Otrelo-Cardoso, A. R., Schwuchow, V., Sigfridsson Clauss, K. G. V., Haumann, M., Romão, M. J., Leimkühler, S. & Santos-Silva, T., 21 Oct 2016, In : ACS Chemical Biology. 11, 10, p. 2923-2935 13 p.

Research output: Contribution to journalArticle

11 Citations (Scopus)
2015

A contribution to the rational design of Ru(CO)3Cl2L complexes for in vivo delivery of CO

Seixas, J. D., Santos, M. F. A., Mukhopadhyay, A., Coelho, A. C., Reis, P. M., Veiros, L. F., Marques, A. R., Penacho, N., Gonçalves, A. M. L., Romão, M. J., Bernardes, G. J. L., Santos-Silva, T. S. & Romao, C. J., 21 Mar 2015, In : Dalton Transactions. 44, 11, p. 5058-5075 18 p.

Research output: Contribution to journalArticle

36 Citations (Scopus)
3 Citations (Scopus)

Ligand Binding to Chlorite Dismutase from Magnetospirillum sp.javascript:void(0);

De Schutter, A., Correia, H. D., Freire, D. M., Rivas, M. G., Rizzi, A., Santos-Silva, T., González, P. J. & Van Doorslaer, S., 29 Oct 2015, In : Journal of Physical Chemistry B. 119, 43, p. 13859-13869 11 p.

Research output: Contribution to journalArticle

8 Citations (Scopus)

Structural insights into xenobiotic and inhibitor binding to human aldehyde oxidase

Coelho, C. M. C., Foti, A., Hartmann, T., Santos-Silva, T. S., Leimkühler, S. & Romão, M. J., 2015, In : Nature Chemical Biology. 11, 10, p. 779-783 5 p.

Research output: Contribution to journalArticle

47 Citations (Scopus)

The homopentameric chlorite dismutase from Magnetospirillum sp.

Freire, D. M., Rivas, M. G., Dias, A. M., Lopes, A. T., Costa, C., Santos-Silva, T., Van Doorslaer, S. & González, P. J., 27 Jul 2015, In : Journal of Inorganic Biochemistry. 151, p. 1-9 9 p.

Research output: Contribution to journalArticle

7 Citations (Scopus)

Vanadium and proteins: Uptake, transport, structure, activity and function

Costa Pessoa, J., Garribba, E., Santos, M. F. A. & Santos-Silva, T., 15 Oct 2015, In : Coordination Chemistry Reviews. 301-302, p. 49-86 38 p.

Research output: Contribution to journalReview article

90 Citations (Scopus)
2014

Biochemical, Stabilization and Crystallization Studies on a Molecular Chaperone (PaoD) Involved in the Maturation of Molybdoenzymes

Otrelo-Cardoso, A. R., Schwuchow, V., Rodrigues, D., Cabrita, E. J., Leimkuehler, S., Romao, M. J. & Santos-Silva, T., 31 Jan 2014, In : PlosOne. 9, 1, 9 p., e87295.

Research output: Contribution to journalArticle

7 Citations (Scopus)

New insights on vanadium binding to human serum transferrin

Costa Pessoa, J., Gonçalves, G., Roy, S., Correia, I., Mehtab, S., Santos, M. F. A. & Santos-Silva, T., 24 Aug 2014, In : Inorganica Chimica Acta. 420, p. 60-68 9 p.

Research output: Contribution to journalArticle

33 Citations (Scopus)

Structural Data on the Periplasmic Aldehyde Oxidoreductase PaoABC from Escherichia coli: SAXS and Preliminary X-ray Crystallography Analysis

Otrelo-Cardoso, A. R., da Silva Correia, M. A., Schwuchow, V., Svergun, D. I., Romão, M. J., Leimkuehler, S. & Santos-silva, T. S., Feb 2014, In : International Journal of Molecular Sciences. 15, 2, p. 2223-2236

Research output: Contribution to journalArticle

Open Access
6 Citations (Scopus)

TupA: a tungstate binding protein in the periplasm of Desulfovibrio alaskensis G20

Otrelo-Cardoso, A. R., Nair, R. R., Correia, M. A. S., Rivas, M. G. & Santos-Silva, T., 2 Jul 2014, In : International Journal of Molecular Sciences. 15, 7, p. 11783-11798 16 p.

Research output: Contribution to journalArticle

4 Citations (Scopus)

Vanadium Complexes as Prospective Therapeutics: Structural Characterization of a V-IV Lysozyme Adduct

Santos, M. F. A., Correia, I. L., Ricardo, A. I. N. M. A. D. O., Garribba, E., Pessoa, J. C. & Santos-Silva, T., Jul 2014, In : European Journal of Inorganic Chemistry. 21, p. 3293-3297 5 p.

Research output: Contribution to journalArticle

36 Citations (Scopus)
2013

Characterization of a versatile organometallic pro-drug (CORM) for experimental CO based therapeutics

Seixas, J. D., Mukhopadhyay, A., Santos-silva, T. S., Otterbein, L. E., Gallo, D. J., Rodrigues, S. S., Guerreiro, B., Gonçalves, A. M. L., Penacho, N., Marques, A. R., Coelho, A. C., Reis, P. M., Romão, M. J. & Romao, C. C., 7 May 2013, In : Dalton Transactions. 42, 17, p. 5985-5998

Research output: Contribution to journalArticle

39 Citations (Scopus)

Interaction of vanadium (IV) with human serum apo-transferrin.

Santos-silva, T. S. & Romão, M. J., 1 Jan 2013, In : Journal of Inorganic Biochemistry. 121, NA, p. 187-95

Research output: Contribution to journalArticle

Open Access
52 Citations (Scopus)
Open Access
File
3 Citations (Scopus)
1 Downloads (Pure)

Vanadium compounds as prospective therapeutics: X-ray structure of protein adducts

Santos-silva, T. S. & Romão, M. J., 1 Jan 2013, 233 SPRING ST, NEW YORK, NY 10013 USA : Springer.

Research output: Other contribution

2011

CORM-3 Reactivity toward Proteins: The Crystal Structure of a Ru(II) Dicarbonyl-Lysozyme Complex

Santos-silva, T. S., Mukhopadhyay, A., Seixas, J. D., Bernardes, G. J. L., Romao, C. J. & Romão, M. J., 4 Jan 2011, In : Journal of the American Chemical Society. 133, 5, p. 1192-1195

Research output: Contribution to journalArticle

Open Access
126 Citations (Scopus)
Open Access
42 Citations (Scopus)

Ring-Functionalized Molybdenocene Complexes

Santos-silva, T. S., Romão, M. J. & Romao, C. J., 11 May 2009, In : Organometallics. 28, 9, p. 2871-2879

Research output: Contribution to journalArticle

Open Access
19 Citations (Scopus)
2008

Ion jelly: A tailor-made conducting material for smart electrochemical devices

Vidinha, P., Lourenço, N. M. T., Pinheiro, C., Brás, A. R., Carvalho, T., Santos-Silva, T., Mukhopadhyay, A., Romão, M. J., Parola, J., Dionisio, M., Cabral, J. M. S., Afonso, C. A. M. & Barreiros, S., 24 Nov 2008, In : Chemical Communications. 44, p. 5842-5844 3 p.

Research output: Contribution to journalArticle

64 Citations (Scopus)
2006
35 Citations (Scopus)
2005
Open Access
File
5 Citations (Scopus)
3 Downloads (Pure)
2004
3 Citations (Scopus)

Mutagenesis study on amino acids around the molybdenum centre of the periplasmic nitrate reductase from Ralstonia eutropha

Hettmann, T., Siddiqui, R. A., Frey, C., Santos-Silva, T., Romão, M. J. & Diekmann, S., 6 Aug 2004, In : Biochemical And Biophysical Research Communications. 320, 4, p. 1211-1219 9 p.

Research output: Contribution to journalArticle

14 Citations (Scopus)