Research output per year
Research output per year
Doctor
DQ - Departamento de Química
Faculdade de Ciências e Tecnologia/UNL
Edifício Departamental
Campus de Caparica
2829-516 Caparica
Portugal
Accepting PhD Students
PhD projects
Microbial Stress - Bacterial Peroxidases in Pathogenic Bacteria
Microbial Stress - Copper stress in Pathogenic Bacteria
Antimicrobial activity of organometallic compounds
Research activity per year
Sofia R. Pauleta has finished her Ph.D. in Biochemistry-Biophysical Chemistry, in 2003 from the NOVA University of Lisbon. In 2007, after a post-doctoral fellowship under the co-supervision of Prof. Ivano Bertini and Prof. Paola Turano, at CERM, University of Florence (Italy) she returned to Portugal. She was awarded an Assistant Researcher position at REQUIMTE, followed by a IF-FCT-2013 researcher, a highly competitive program, as Principal Investigator, and in 2019 started the tenure-track position as Assistant Professor at FCT NOVA (teaching at the level of BSc, Master and PhD degree), and since 2022 is the Coordinator of Master degree in Biochemistry FCT NOVA.
Since 2009, after receiving her first independent research grant she started her own research lab, as PI of the Microbial Stress Lab@UCIBIO NOVA. At the moment, her team has 1 postdoctoral researcher (Junior researcher), 2 PhD students, 2 Master students (1 is an Erasmus students from Italy) and 2 undergraduate students.
Her lab uses Neisseria gonorrhoeae, Escherichia coli and Staphylococcus aureus, as model organisms. These bacteria are considered by CDC to be urgent health threats and are classified by WHO as high priority pathogens for R&D of new antibiotics; thus, Microbial Stress Lab aims to identify and characterize enzymes as new drug targets, which will have an impact on both the health care system and society. These enzymes are involved in detoxification of reactive oxygen species, metal resistance and alternative electron acceptors (nitrite and nitrate), which are essential during infection. In addition, her lab has been focusing on the contribution of these enzymes/protein to biofilm formation and on the identification of compounds with antimicrobial activity and anti-biofilm as possible inhibitors of these enzymes.
Her lab has expertise in steady-state kinetics, spectroscopic techniques (visible, EPR, NMR, CD, resonance Raman), biomolecular NMR, microcalorimetry (ITC and DSC) and heterologous production of metalloproteins, biofilm formation and composition (E. coli, methicillin-resistant S. aureus).
Biochemistry, Doctorate, Electron transfer complexes between Paracoccus pantotrophus cytochrome c peroxidase and its electron donors, Universidade NOVA de Lisboa
1 Oct 1998 → 30 Sept 2002
Award Date: 7 Nov 2003
Biotechnology, Bachelor, Applied Chemistry, Faculdade de Ciências e Tecnologia (FCT)
1 Oct 1993 → 30 Jun 1998
Award Date: 30 Jun 1998
Research output: Contribution to journal › Article › peer-review
Research output: Contribution to journal › Article › peer-review
Research output: Contribution to journal › Article › peer-review
Research output: Contribution to journal › Article › peer-review
Research output: Contribution to journal › Article › peer-review
Pauleta, S. (Creator), Biological Magnetic Resonance Data Bank, 29 Sept 2015
DOI: 10.13018/BMR26618, https://bmrb.io/data_library/summary/index.php?bmrbId=26618
Dataset
Pauleta, S. (Creator), RCSB Protein Data Bank, 2014
DOI: 10.2210/pdb2MPF/pdb, https://www.rcsb.org/structure/2mpf
Dataset
Pauleta, S. (Creator), RCSB Protein Data Bank, 2016
DOI: 10.2210/pdb2N0M/pdb, https://www.rcsb.org/structure/2N0M
Dataset
Pauleta, S. (Creator), Biological Magnetic Resonance Data Bank, 23 Aug 2007
DOI: 10.13018/BMR15200, https://bmrb.io/data_library/summary/index.php?bmrbId=15200
Dataset
Pauleta, S. (Creator), Biological Magnetic Resonance Data Bank, 2 Sept 2014
DOI: 10.13018/BMR19977, https://bmrb.io/data_library/summary/index.php?bmrbId=19977
Dataset
Pauleta, Sofia (Recipient), 1 May 2020
Prize: Prize (including medals and awards)
Pauleta, Sofia (Recipient), Feb 2022
Prize: National/international honour
Sofia Pauleta (Speaker)
Activity: Talk or presentation › Invited talk
Sofia Pauleta (Speaker)
Activity: Talk or presentation › Oral presentation
Sofia Pauleta (Speaker)
Activity: Talk or presentation › Invited talk
Sofia Pauleta (Examiner)
Activity: Examination
Sofia Pauleta (Main Examiner)
Activity: Examination