Research output per year
Research output per year
Personal profile
Research interests
(Nano)Theranostics effectively brings together diagnostics and therapeutics onto a single platform making them powerful tools in biomedicine. This even more so when using nanoscale structures, whose optical, (eletro)chemical and biological properties make them optimal biosensing transducers for theranostics agents. When designing a nanotheranostics, one should take into consideration:
- the choice of most suitable nanocarrier for effective delivery for tissue delivery and cell internalization;
- the effector molecule, from standard drugs to nucleic acids;
- to ensure controlled release of effector molecule;
- the signal transducer (e.g. imaging) component that allows for the real time monitoring of the nanoconjugate location and effect on target tissue cells;
- an active targeting agent, typically a cell-surface marker or an oligonucleotide, that maximizes specificity of the vector and minimizes damages to healthy cells.
Nanomedicine@FCT aims to highlight recent advances in the development of novel biosensing schemes and strategies that potentiate and enhance the performance of (nano)theranostics applications with a strong focus on those suitable for translation to the clinics.
Keywords: Nanomedicine; Cancer; Human Molecular Genetics; Nanoparticles; Diagnostics; Therapeutics; Gene silencing
Education/Academic qualification
Biotechnology, Doctorate, University of London
Award Date: 1 Jan 2001
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Research output
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A Transcriptomic Approach to the Recruitment of Venom Proteins in a Marine Annelid
Rodrigo, A. P., Grosso, A. R., Baptista, P. V., Fernandes, A. R. & Costa, P. M., 28 Jan 2021, In: Toxins. 13, 2, 97.Research output: Contribution to journal › Article › peer-review
Open AccessFile2 Citations (Scopus)1 Downloads (Pure) -
Benchtop X-ray fluorescence imaging as a tool to study gold nanoparticle penetration in 3D cancer spheroids
Pedrosa, P., Baptista, P. V., Fernandes, A. R. & Guerra, M., 22 Jul 2021, In: RSC Advances. 11, 42, p. 26344-26353 10 p.Research output: Contribution to journal › Article › peer-review
Open AccessFile -
Combined cancer therapeutics—Tackling the complexity of the tumor microenvironment
Roma-Rodrigues, C., Raposo, L. R., Valente, R., Fernandes, A. R. & Baptista, P. V., Sep 2021, In: Wiley Interdisciplinary Reviews: Nanomedicine and Nanobiotechnology. 13, 5, e1704.Research output: Contribution to journal › Review article › peer-review
1 Citation (Scopus) -
Copper(ii) complexes with tridentate halogen-substituted Schiff base ligands: synthesis, crystal structures and investigating the effect of halogenation, leaving groups and ligand flexibility on antiproliferative activities
Kordestani, N., Amiri Rudbari, H., Fernandes, A. R., Raposo, L. R., Luz, A., Baptista, P. V., Bruno, G., Scopelliti, R., Fateminia, Z., Micale, N., Tumanov, N., Wouters, J., Abbasi Kajani, A. & Bordbar, A. K., 21 Mar 2021, In: Dalton Transactions. 50, 11, p. 3990-4007 18 p.Research output: Contribution to journal › Article › peer-review
4 Citations (Scopus) -
Cu(i) complexes as new antiproliferative agents against sensitive and doxorubicin resistant colorectal cancer cells: synthesis, characterization, and mechanisms of action
Sequeira, D., Baptista, P. V., Valente, R., Piedade, M. F. M. M., Garcia, M. H., Morais, T. S. & Fernandes, A. R., 7 Feb 2021, In: Dalton Transactions. 50, 5, p. 1845-1865 21 p.Research output: Contribution to journal › Article › peer-review
2 Citations (Scopus)
Prizes
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GILEAD Award - Aplicação de nanopartículas superparamagnéticas no diagnostico rápido, simultâneo e não invasivo da infeção pelo VIH e da tuberculose
Machado, Diana Isabel Oliveira (Recipient), Viveiros, Miguel (Recipient), Piedade, João Mário Brás da (Recipient) & Baptista, Pedro Miguel Ribeiro Viana (Recipient), 2018
Prize: Prize (including medals and awards)
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Merit Award for Best Panel Communication - “Cell and Tissue Engineering, Biomaterials and Nanobiotechnologies”
Veigas, B. (Recipient), Perdigão , J. (Recipient), Portugal, I. (Recipient), Couto, Isabel Maria dos Santos Leitão (Recipient), Viveiros, Miguel (Recipient) & Baptista, Pedro Miguel Ribeiro Viana (Recipient), 2009
Prize: Prize (including medals and awards)
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Merit Award Santander/Totta 2012 - "NanoTB - Nanodiagnostics for XDRTB at point-of-need"
Viveiros, Miguel (Recipient), Baptista, Pedro Miguel Ribeiro Viana (Recipient) & Couto, Isabel Maria dos Santos Leitão (Recipient), 2012
Prize: Prize (including medals and awards)