• 5913 Citations
  • 43 h-Index
1992 …2020

Research output per year

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Personal profile

Research interests

Profile: Full Professor in Biomedical Sciences - Medical Microbiology and Vice-Director of the Institute of Hygiene and Tropical Medicine of the New University of Lisbon. Professor in Biomedical Sciences, International Health and Tropical Medicine - Early diagnosis of active or latent TB and new therapeutics for MDRTB and XDRTB. Devoted to the study and development of new diagnostic tools and alternative therapies to treat drug resistant infectious diseases such as multidrug resistant tuberculosis and methicillin-vancomycin resistant staphylococcal infections, using new biotechnologies and new therapies incorporating non-antibiotic adjuvants of chemotherapy. Specialist in the laboratory diagnosis and characterization of the determinants for resistance by phenotypic and genotypic assays, using new technical approaches such as Whole genome sequencing and real-time phenotypic assays. These studies also demonstrated the public health implications associated with these findings and contributed to the improvement of the currently recommended first and second line multi-drug anti-TB treatments.  Scientific Coordinator of the Foundation of Science and Technology Research Center – Global Health and Tropical Medicine (UID/04413/2020) since 2020. Founding member and Treasurer, currently management committee member of the Study Group for Mycobacterial Infections (ESGMYC) of the European Society of Clinical Microbiology and Infectious Diseases (ESCMID) (https://www.escmid.org/index.php?id=897 ). General Director and Scientific Coordinator of the “Ciência LP - International Center for Advanced Training in Fundamental Sciences for Scientists from Portuguese-speaking Countries” (UNESCO Category 2 Center) (https://www.ciencialp.pt/centro-ciencia-lp/) and Vice-President of the Portuguese Society for Microbiology (https://spmicrobiologia.wordpress.com/orgaos-sociais/). Vice-Chair (2017) and Chair (2019) of the Gordon Research Conference - Multi-Drug Efflux Systems -  https://www.grc.org/multi-drug-efflux-systems-conference/2019/). Member of the National Council for Heath appointed by The Board of Biologists of Portugal (http://www.cns.min-saude.pt/2017/09/27/membros/). Member of the evaluation panel of Fundação para a Ciência e a Tecnologia of Portugal and expert Evaluator for the MRC South Africa and UK (area Tuberculosis), Wellcome Trust Awards, The Research Foundation – Flanders (FWO), Belgium, Dutch Research Council (NWO), Holland, Haut Conseil de l'Évaluation de la Recherche et de l'Enseignement Supérieur (HCERES) and National Agency for Scientific Evaluation (ANEP), Spain. Author/co-author of over 200 scientific papers in peer review national and international journals, books and book-chapters in mycobacteriology, tuberculosis, bacteriology, resistance to antibiotics, microbial genetics, molecular epidemiology and immunology.

http://orcid.org/0000-0001-9676-6251

https://www.cienciavitae.pt/DF17-B4BF-8756

 Research: Expert in the early diagnosis of active or latent TB and new therapeutics for MDRTB and XDRTB. Devoted to the study and development of new diagnostic tools and alternative therapies to treat drug resistant diseases such as multidrug resistant tuberculosis and methicillin-vancomycin resistant staphylococcal infections, using new biotechnologies and new therapies incorporating non-antibiotic adjuvants of chemotherapy. Studied, in the last 15 years, the contribution of the efflux-pumps and membrane transporters to bacterial multidrug resistant phenotypes and how we can prevent, reverse or reduce the level of resistance and recover the effectiveness of the antibiotics to which the bacteria became resistant. With an international team of collaborators, documented the mutations in drug targets and the corresponding associated minimal inhibitory concentrations for the majority of the anti-TB drug targets in M. tuberculosis and well as the effectiveness of various new inhibitors on many of the MDR bacteria in particular M/XDRTB. Conducted the laboratory diagnosis and the characterization of the determinants for resistance by phenotypic and genotypic assays, using new technical approaches such as Whole genome sequencing and real-time phenotypic assays. These studies also demonstrated the public health implications associated with these findings and contributed to the improvement of the currently recommended first and second line multi-drug anti-TB treatments. Involved in the design and conduction of several multicenter studies in the field of mycobacteriology and laboratory diagnosis of tuberculosis involving, Becton & Dickinson, EUCAST, ESGMYC and TB Alliance, and pharmaceutical companies like Janssen, Otsuka and Tecnimede. Participated in the validation of the SIRE KIT Nitratase for M. tuberculosis DST with the Brazilian TB lab-network. Deeply involved in the development of TB nanodiagnostics in collaboration with the Nanotheranostics Group FCT/UNL (PI - Pedro V. Baptista).

External positions

invited professor at the Faculdade de Medicina do Rio de Janeiro (Brasil).

1 Oct 20141 Jan 2018

Keywords

  • R Medicine (General)
  • Infectious desiases
  • Tuberculosis
  • Tropical Medicine
  • Global Health
  • QR180 Immunology
  • Medical Microbiology
  • Antibiotic Resistance
  • Efflux pumps
  • Bacteriology
  • Membrane transport

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Research Output at NOVA

Open Access
File
  • 1 Citation (Scopus)
    5 Downloads (Pure)

    Antimicrobial susceptibility testing of Mycobacterium tuberculosis complex isolates: the EUCAST broth microdilution reference method for MIC determination

    Schön, T., Werngren, J., Machado, D., Borroni, E., Wijkander, M., Lina, G., Mouton, J., Matuschek, E., Kahlmeter, G., Giske, C., Santin, M., Cirillo, D. M., Viveiros, M. & Cambau, E., 1 Aug 2020, In : Clin. Microbiol. Infect. Supl. 1198-743x, n.º 20, p. 30444-30465 21 p.

    Research output: Contribution to journalArticle

  • Colistin heteroresistance in carbapenemase-producing Acinetobacter baumannii

    Machado, D., Gothe, S., Martins, M., Pacheco, T., Batista, J., Toscano, C. & Viveiros, M., 2020.

    Research output: Contribution to conferenceAbstract

    Design, synthesis, and evaluation of new 2-(quinoline-4-yloxy)acetamide-based antituberculosis agents

    Borsoi, A. F., Paz, J. D., Abbadi, B. L., Macchi, F. S., Sperotto, N., Pissinate, K., Rambo, R. S., Ramos, A. S., Machado, D., Viveiros, M., Bizarro, C. V., Basso, L. A. & Machado, P., 15 Apr 2020, In : European Journal of Medicinal Chemistry. Vol. 192, p. 112179 112179.

    Research output: Contribution to journalArticle

  • Detection of drug resistant mycobacterium tuberculosis strains using kit SIRE nitratase®: A multicenter study

    de Miranda, S. S., de Almeida, I. N., de Fátima Filardi Oliveira Mansur, M., de Assis Figueredo, L. J., da Silva Carvalho, W., Hadaad, J. P. A., de Lourdes do Carmo Guimarães Diniz, J., von Groll, A., da Silva, P. A., Lopes, M. L., dos Santos, M. C., Brito, A., de Queiroz Mello, F. C., da Silva Santos Malaquias, T., Croda, J., Pinhata, J. M. W., de Oliveira, R. S., Chimara, E., Rossetti, M. L., Halon, M. L. & 6 others, Lourenço, M. C., de Melo Medeiros, R. F., Montes, F. C. O. F., Machado, D., Viveiros, M. & Kritski, A. L., 2020, In : Brazilian Archives Of Biology And Technology. 63, p. 1-9 9 p., e20190179.

    Research output: Contribution to journalArticle

    Open Access
  • Prizes

    Best Panel Communication on the Section “Health Microbiology and Biotechnology”: “Correlation between carbapenem resistance, β-lactamases, porins and efflux pumps in Acinetobacter baumannii clinical isolates.”

    Jéssica Antunes (Recipient), Diana Isabel Oliveira Machado (Recipient), Isabel Maria dos Santos Leitão Couto (Recipient), Teresa Pacheco (Recipient), Judite Batista (Recipient), Cristina Toscano (Recipient) & Miguel Viveiros (Recipient), 2017

    Prize: Prize (including medals and awards)

    Merit Award for Best Panel Communication - “Cell and Tissue Engineering, Biomaterials and Nanobiotechnologies”

    Bruno Veigas (Recipient), J Perdigão (Recipient), Isabel Portugal (Recipient), Isabel Maria dos Santos Leitão Couto (Recipient), Miguel Viveiros (Recipient) & Pedro Miguel Ribeiro Viana Baptista (Recipient), 2009

    Prize: Prize (including medals and awards)

    Activities

    • 24 Invited talk
    • 2 Oral presentation
    • 1 Participation in conference

    The contribution of membrane transporter proteins to extensively-drug resistant phenotypes in Acinetobacter baumannii

    Miguel Viveiros (Speaker)
    30 Jun 20193 Jul 2019

    Activity: Talk or presentationOral presentation

    Ciência 2019

    Ana Tavares (Participant), Marta Pingarilho (Participant), Perpétua Gomes (Participant), Miguel Viveiros (Participant), Ana Barroso Abecasis (Participant)
    8 Jul 2019

    Activity: Participating in or organising an eventParticipation in conference