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Research Output at NOVA

2020
Open Access
File
2019

Accurate Determination of Human CPR Conformational Equilibrium by smFRET using Dual Orthogonal Non-Canonical Amino Acid Labeling

Quast, R. B., Fatemi, F., Kranendonk, M., Margeat, E. & Truan, G., Mar 2019, In : Chembiochem. 20, 5, p. 659-666

Research output: Contribution to journalArticle

1 Citation (Scopus)
2018
Open Access
File
4 Downloads (Pure)

Human cytochrome P450 expression in bacteria: Whole-cell high-throughput activity assay for CYP1A2, 2A6 and 3A4

Esteves, F., Campelo, D., Urban, P., Bozonnet, S., Lautier, T., Rueff, J., Truan, G. & Kranendonk, M., Dec 2018, In : Biochemical pharmacology. 158, p. 134-140 7 p.

Research output: Contribution to journalArticle

2 Citations (Scopus)
Open Access
File
1 Citation (Scopus)
4 Downloads (Pure)

Role of Protein-Protein Interactions in Metabolism: Genetics, Structure, Function

Pandey, A. V., Henderson, C. J., Ishii, Y., Kranendonk, M., Backes, W. L. & Zanger, U. M., Jan 2018, Frontiers Media S. A. 152 p. (Role of Protein-Protein Interactions in Metabolism: Genetics, Structure, Function)

Research output: Book/ReportBook

Open Access
File
287 Downloads (Pure)
2017

Editorial: Role of Protein-Protein Interactions in Metabolism: Genetics, Structure, Function

Pandey, A. V., Henderson, C. J., Ishii, Y., Kranendonk, M., Backes, W. L. & Zanger, U. M., 27 Nov 2017, In : Frontiers in Pharmacology. 8, 3 p.

Research output: Contribution to journalEditorial

Open Access
File
2 Citations (Scopus)
8 Downloads (Pure)

The hinge segment of human NADPH-cytochrome P450 reductase in conformational switching: The critical role of ionic strength

Campelo, D., Lautier, T., Urban, P., Esteves, F., Bozonnet, S., Truan, G. & Kranendonk, M., 30 Oct 2017, In : Frontiers in Pharmacology. 8, OCT, p. Online 13 p., 755.

Research output: Contribution to journalArticle

Open Access
File
6 Citations (Scopus)
32 Downloads (Pure)
2016
2 Citations (Scopus)

Instability of the human cytochrome P450 reductase A287P variant is the major contributor to its Antley-Bixler syndrome-like phenotype

McCammon, K. M., Panda, S. P., Xia, C., Kim, J. J. P., Moutinho, D., Kranendonk, M., Auchus, R. J., Lafer, E. M., Ghosh, D., Martasek, P., Kar, R., Masters, B. S. & Roman, L. J., 23 Sep 2016, In : Journal of Biological Chemistry. 291, 39, p. 20487-20502 16 p.

Research output: Contribution to journalArticle

13 Citations (Scopus)
2 Citations (Scopus)
2014
4 Citations (Scopus)
2013

Functional characterization of eight human CYP1A2 variants: The role of cytochrome b5

Palma, B. B., Silva E Sousa, M., Urban, P., Rueff, J. & Kranendonk, M., 1 Feb 2013, In : Pharmacogenetics And Genomics. 23, 2, p. 41-52 12 p.

Research output: Contribution to journalArticle

17 Citations (Scopus)
2012

Altered Human CYP3A4 Activity Caused by Antley-Bixler Syndrome-Related Variants of NADPH-Cytochrome P450 Oxidoreductase Measured in a Robust In Vitro System

Moutinho, D., Marohnic, C. C., Panda, S. P., Rueff, J., Masters, B. S. S. S. S. & Kranendonk, M., Apr 2012, In : Drug Metabolism And Disposition. 40, 4, p. 754-760 7 p.

Research output: Contribution to journalArticle

20 Citations (Scopus)
2010

Alkylating Potential of Oxetanes

Gomez-Bombarelli, R., Palma, B. B., Martins, C., Kranendonk, M., Rodrigues, A. S., Calle, E., Rueff, J. & Casado, J., Jul 2010, In : Chemical Research In Toxicology. 23, 7, p. 1275-1281 7 p.

Research output: Contribution to journalArticle

6 Citations (Scopus)

Functional characterization of eight human cytochrome P450 1A2 gene variants by recombinant protein expression

Palma, B. B., Sousa, M. S., Vosmeer, C. R., Lastdrager, J., Rueff, J., Vermeulen, N. P. E. & Kranendonk, M., Dec 2010, In : Pharmacogenomics Journal. 10, 6, p. 478-488 9 p.

Research output: Contribution to journalArticle

21 Citations (Scopus)

Human Cytochrome P450 Oxidoreductase Deficiency Caused by the Y181D Mutation: Molecular Consequences and Rescue of Defect

Marohnic, C. C., Panda, S. P., McCammon, K. M., Rueff, J., Masters, B. S. S. & Kranendonk, M., 1 Jan 2010, In : Drug Metabolism And Disposition. 38, 2, p. 332-340

Research output: Contribution to journalArticle

Open Access
File
40 Citations (Scopus)
11 Downloads (Pure)
2008
38 Citations (Scopus)
2007

Antley-Bixler Syndrome-Related Mutants of Human NADPH-Cytochrome P450 Reductase: Effects on Drug Metabolism and Mutagenesis

Duarte, M. P. A. D. C., Kranendonk, M. & Rueff, J., 1 Jan 2007, NA. Vol. na. p. 78

Research output: Chapter in Book/Report/Conference proceedingConference contribution

2006

Genotoxicity and endoreduplication inducing activity of the food flavouring eugenol

Maralhas, A., Monteiro, A., Martins, C., Kranendonk, M., Laires, A., Rueff, J. & Rodrigues, A. S., 2006, In : Mutagenesis. 21, 3, p. 199-204 5 p.

Research output: Contribution to journalArticle

51 Citations (Scopus)

The role of protein-protein interactions in the stimulation of the bioactivation by CYP1A2, 2A6 and 2E1 in the presence of cytochrome b5: A new cell system to study cytochrome P450 mediated biotransformation

Duarte, MP., Kranendonk, M. & Rueff, J., 1 Jan 2005, Proceedings of the 14th International Conference on Cytochromes P450: Biochemistry, Biophysics, and Bioinformatics. p. 121-125

Research output: Chapter in Book/Report/Conference proceedingConference contribution

20 Citations (Scopus)
2002

Development of PD1000: a new Escherichia coli strain, highly sensitive towards the detection of alkylating agents.

Duarte, M. P. A. D. C., Kranendonk, M. & Rueff, J., 1 Jan 2002, NA. p. 167

Research output: Chapter in Book/Report/Conference proceedingConference contribution

DNA polymorphisms as modulators of genotoxicity and cancer

Rueff, J., Gaspar, J. & Kranendonk, M., 1 Jan 2002, In : Biological Chemistry. 383, 6, p. 923-932

Research output: Contribution to journalArticle

7 Citations (Scopus)
2000

Heterologous expression of xenobiotic mammalian-metabolizing enzymes in mutagenicity tester bacteria: An update and practical considerations

Kranendonk, M., Laires, A., Rueff, J., Estabrook, R. W. & Vermeulen, N. P. E., 2000, In : Critical Reviews In Toxicology. 30, 3, p. 287-306 20 p.

Research output: Contribution to journalReview article

16 Citations (Scopus)
1999
29 Citations (Scopus)

Escherichia coli MTC, a NADPH cytochrome P450 reductase competent mutagenicity tester strain for the expression of human cytochrome P450: Comparison of three types of expression systems

Kranendonk, M., Fisher, C. W., Roda, R., Carreira, F., Theisen, P., Laires, A., Rueff, J., Vermeulen, N. P. E. & Estabrook, R. W., 19 Feb 1999, In : Mutation Research - Genetic Toxicology and Environmental Mutagenesis. 439, 2, p. 287-300 14 p.

Research output: Contribution to journalArticle

22 Citations (Scopus)
1998

Expression of human cytochrome P450 1A2 in Escherichia coli: A system for biotransformation and genotoxicity studies of chemical carcinogens

Kranendonk, M., Mesquita, P., Laires, A., Vermeulen, N. P. E. & Rueff, J., May 1998, In : Mutagenesis. 13, 3, p. 263-269 7 p.

Research output: Contribution to journalArticle

42 Citations (Scopus)
1997
25 Citations (Scopus)
2 Citations (Scopus)
1996

MX100, a new Escherichia coli tester strain for use in genotoxicity studies

Kranendonk, M., Pintado, F., Mesquita, P., Laires, A., Vermeulen, N. P. E. & Rueff, J., Jul 1996, In : Mutagenesis. 11, 4, p. 327-333 7 p.

Research output: Contribution to journalArticle

21 Citations (Scopus)
1994
12 Citations (Scopus)