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Research Output at NOVA 1994 2019

2019
1 Citation (Scopus)

Accurate Determination of Human CPR Conformational Equilibrium by smFRET using Dual Orthogonal Non-Canonical Amino Acid Labeling

Quast, R. B., Fatemi, F., Kranendonk, M., Margeat, E. & Truan, G., Mar 2019, In : Chembiochem. 20, 5, p. 659-666

Research output: Contribution to journalArticle

NADPH-Ferrihemoprotein Reductase
Energy Transfer
Energy transfer
Labeling
Coloring Agents
Microsomes
Salmonella
Toxicology
Mutation
Research
2018
4 Downloads (Pure)
Open Access
File
NADPH-Ferrihemoprotein Reductase
Osmolar Concentration

Human cytochrome P450 expression in bacteria: Whole-cell high-throughput activity assay for CYP1A2, 2A6 and 3A4

Esteves, F., Campelo, D., Urban, P., Bozonnet, S., Lautier, T., Rueff, J., Truan, G. & Kranendonk, M., Dec 2018, In : Biochemical pharmacology. 158, p. 134-140 7 p.

Research output: Contribution to journalArticle

Cytochrome P-450 CYP1A2
Cytochromes
Cytochrome P-450 Enzyme System
Assays
Bacteria
4 Downloads (Pure)
Open Access
File
NADPH-Ferrihemoprotein Reductase
hinges
cytochromes
Hinges
Cytochrome P-450 Enzyme System
127 Downloads (Pure)

Role of Protein-Protein Interactions in Metabolism: Genetics, Structure, Function

Pandey, A. V., Henderson, C. J., Ishii, Y., Kranendonk, M., Backes, W. L. & Zanger, U. M., Jan 2018, Frontiers Media S. A. 152 p. (Role of Protein-Protein Interactions in Metabolism: Genetics, Structure, Function)

Research output: Book/ReportBook

Open Access
File
2017
1 Citation (Scopus)
7 Downloads (Pure)

Editorial: Role of Protein-Protein Interactions in Metabolism: Genetics, Structure, Function

Pandey, A. V., Henderson, C. J., Ishii, Y., Kranendonk, M., Backes, W. L. & Zanger, U. M., 27 Nov 2017, In : Frontiers in Pharmacology. 8, 3 p.

Research output: Contribution to journalEditorial

Open Access
File
4 Citations (Scopus)
30 Downloads (Pure)

The hinge segment of human NADPH-cytochrome P450 reductase in conformational switching: The critical role of ionic strength

Campelo, D., Lautier, T., Urban, P., Esteves, F., Bozonnet, S., Truan, G. & Kranendonk, M., 30 Oct 2017, In : Frontiers in Pharmacology. 8, OCT, p. Online 13 p., 755.

Research output: Contribution to journalArticle

Open Access
File
NADPH-Ferrihemoprotein Reductase
Osmolar Concentration
Salts
Cytochromes c
Oxidation-Reduction
2016
2 Citations (Scopus)
Cytochrome P-450 CYP1A2
Cytochrome P-450 Enzyme System
2-amino-3-methylimidazo(4,5-f)quinoline
Mutagens
NADPH-Ferrihemoprotein Reductase
12 Citations (Scopus)

Instability of the human cytochrome P450 reductase A287P variant is the major contributor to its Antley-Bixler syndrome-like phenotype

McCammon, K. M., Panda, S. P., Xia, C., Kim, J. J. P., Moutinho, D., Kranendonk, M., Auchus, R. J., Lafer, E. M., Ghosh, D., Martasek, P., Kar, R., Masters, B. S. & Roman, L. J., 23 Sep 2016, In : Journal of Biological Chemistry. 291, 39, p. 20487-20502 16 p.

Research output: Contribution to journalArticle

Antley-Bixler Syndrome Phenotype
NADPH-Ferrihemoprotein Reductase
Oxidoreductases
Differential Scanning Calorimetry
Proteins
2 Citations (Scopus)
Metabolites
Cytochrome P-450 Enzyme System
DNA Damage
Throughput
Assays
2014
4 Citations (Scopus)
Nevirapine
Metabolites
Liver
Skin
Mutagenicity Tests
2013
16 Citations (Scopus)

Functional characterization of eight human CYP1A2 variants: The role of cytochrome b5

Palma, B. B., Silva E Sousa, M., Urban, P., Rueff, J. & Kranendonk, M., 1 Feb 2013, In : Pharmacogenetics And Genomics. 23, 2, p. 41-52 12 p.

Research output: Contribution to journalArticle

Cytochromes b5
Cytochrome P-450 CYP1A2
Cytochrome P-450 Enzyme System
Oxidoreductases
NADPH-Ferrihemoprotein Reductase
2012
19 Citations (Scopus)

Altered Human CYP3A4 Activity Caused by Antley-Bixler Syndrome-Related Variants of NADPH-Cytochrome P450 Oxidoreductase Measured in a Robust In Vitro System

Moutinho, D., Marohnic, C. C., Panda, S. P., Rueff, J., Masters, B. S. S. S. S. & Kranendonk, M., Apr 2012, In : Drug Metabolism And Disposition. 40, 4, p. 754-760 7 p.

Research output: Contribution to journalArticle

Antley-Bixler Syndrome Phenotype
Cytochrome P-450 CYP3A
NADPH-Ferrihemoprotein Reductase
Human Activities
Cytochrome P-450 Enzyme System
2010
6 Citations (Scopus)

Alkylating Potential of Oxetanes

Gomez-Bombarelli, R., Palma, B. B., Martins, C., Kranendonk, M., Rodrigues, A. S., Calle, E., Rueff, J. & Casado, J., Jul 2010, In : Chemical Research In Toxicology. 23, 7, p. 1275-1281 7 p.

Research output: Contribution to journalArticle

Alkylating Agents
Epoxy Compounds
Lactones
Assays
Antimitotic Agents
20 Citations (Scopus)

Functional characterization of eight human cytochrome P450 1A2 gene variants by recombinant protein expression

Palma, B. B., Sousa, M. S., Vosmeer, C. R., Lastdrager, J., Rueff, J., Vermeulen, N. P. E. & Kranendonk, M., Dec 2010, In : Pharmacogenomics Journal. 10, 6, p. 478-488 9 p.

Research output: Contribution to journalArticle

Cytochrome P-450 CYP1A2
Recombinant Proteins
Apoproteins
Genes
Carcinogens
39 Citations (Scopus)
9 Downloads (Pure)

Human Cytochrome P450 Oxidoreductase Deficiency Caused by the Y181D Mutation: Molecular Consequences and Rescue of Defect

Marohnic, C. C., Panda, S. P., McCammon, K. M., Rueff, J., Masters, B. S. S. & Kranendonk, M., 1 Jan 2010, In : Drug Metabolism And Disposition. 38, 2, p. 332-340

Research output: Contribution to journalArticle

Open Access
File
2008
37 Citations (Scopus)
Antley-Bixler Syndrome Phenotype
Cytochrome P-450 CYP1A2
Fibromyalgia
Xenobiotics
Metabolism
2007

Antley-Bixler Syndrome-Related Mutants of Human NADPH-Cytochrome P450 Reductase: Effects on Drug Metabolism and Mutagenesis

Duarte, M. P. A. D. C., Kranendonk, M. & Rueff, J., 1 Jan 2007, NA. Vol. na. p. 78

Research output: Chapter in Book/Report/Conference proceedingConference contribution

2006
47 Citations (Scopus)

Genotoxicity and endoreduplication inducing activity of the food flavouring eugenol

Maralhas, A., Monteiro, A., Martins, C., Kranendonk, M., Laires, A., Rueff, J. & Rodrigues, A. S., 2006, In : Mutagenesis. 21, 3, p. 199-204 5 p.

Research output: Contribution to journalArticle

Endoreduplication
Eugenol
Type II DNA Topoisomerase
Food
Aberrations

The role of protein-protein interactions in the stimulation of the bioactivation by CYP1A2, 2A6 and 2E1 in the presence of cytochrome b5: A new cell system to study cytochrome P450 mediated biotransformation

Duarte, MP., Kranendonk, M. & Rueff, J., 1 Jan 2005, Proceedings of the 14th International Conference on Cytochromes P450: Biochemistry, Biophysics, and Bioinformatics. p. 121-125

Research output: Chapter in Book/Report/Conference proceedingConference contribution

19 Citations (Scopus)
Cytochromes b5
Cytochrome P-450 CYP1A2
Biotransformation
Human Activities
Cytochrome P-450 Enzyme System
2002

Development of PD1000: a new Escherichia coli strain, highly sensitive towards the detection of alkylating agents.

Duarte, M. P. A. D. C., Kranendonk, M. & Rueff, J., 1 Jan 2002, NA. p. 167

Research output: Chapter in Book/Report/Conference proceedingConference contribution

7 Citations (Scopus)

DNA polymorphisms as modulators of genotoxicity and cancer

Rueff, J., Gaspar, J. & Kranendonk, M., 1 Jan 2002, In : Biological Chemistry. 383, 6, p. 923-932

Research output: Contribution to journalArticle

2000
16 Citations (Scopus)

Heterologous expression of xenobiotic mammalian-metabolizing enzymes in mutagenicity tester bacteria: An update and practical considerations

Kranendonk, M., Laires, A., Rueff, J., Estabrook, R. W. & Vermeulen, N. P. E., 2000, In : Critical Reviews In Toxicology. 30, 3, p. 287-306 20 p.

Research output: Contribution to journalReview article

Xenobiotics
Biotransformation
Bacteria
Enzymes
Functional analysis
1999
29 Citations (Scopus)
Cytochrome P-450 CYP3A
NADPH-Ferrihemoprotein Reductase
Cytochrome P-450 Enzyme System
Protein Isoforms
Escherichia coli
22 Citations (Scopus)

Escherichia coli MTC, a NADPH cytochrome P450 reductase competent mutagenicity tester strain for the expression of human cytochrome P450: Comparison of three types of expression systems

Kranendonk, M., Fisher, C. W., Roda, R., Carreira, F., Theisen, P., Laires, A., Rueff, J., Vermeulen, N. P. E. & Estabrook, R. W., 19 Feb 1999, In : Mutation Research - Genetic Toxicology and Environmental Mutagenesis. 439, 2, p. 287-300 14 p.

Research output: Contribution to journalArticle

Cytochrome P-450 CYP1A2
NADPH-Ferrihemoprotein Reductase
Cytochrome P-450 Enzyme System
Escherichia coli
Oxidoreductases
1998
41 Citations (Scopus)

Expression of human cytochrome P450 1A2 in Escherichia coli: A system for biotransformation and genotoxicity studies of chemical carcinogens

Kranendonk, M., Mesquita, P., Laires, A., Vermeulen, N. P. E. & Rueff, J., May 1998, In : Mutagenesis. 13, 3, p. 263-269 7 p.

Research output: Contribution to journalArticle

Cytochrome P-450 CYP1A2
Biotransformation
Carcinogens
Escherichia coli
Rats
1997
25 Citations (Scopus)
Escherichia coli K12
Salmonella
Coenzymes
Enzyme activity
Salmonella typhimurium
1996
21 Citations (Scopus)

MX100, a new Escherichia coli tester strain for use in genotoxicity studies

Kranendonk, M., Pintado, F., Mesquita, P., Laires, A., Vermeulen, N. P. E. & Rueff, J., Jul 1996, In : Mutagenesis. 11, 4, p. 327-333 7 p.

Research output: Contribution to journalArticle

Mutagens
Escherichia coli
Escherichia coli K12
Arginine
4-Nitroquinoline-1-oxide
1994
12 Citations (Scopus)
Mutagens
Escherichia coli
DNA Repair
Lipopolysaccharides
Arginine