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Research Output at NOVA 1998 2020

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Article
2020

Clustering Clinical Data in R

Pina, A., Macedo, M. P. & Henriques, R., 1 Jan 2020, In : Methods In Molecular Biology (Clifton, N.J.). 2051, p. 309-343 35 p.

Research output: Contribution to journalArticle

Cluster Analysis
Data Mining
Precision Medicine
Evidence-Based Medicine
Software
2019

2-Deoxyglycosylation towards more effective and bioavailable neuroprotective molecules inspired by nature

Dias, C., Matos, A. M., Blásquez-Sanchez, M. T., Calado, P., Martins, A., Dätwyler, P., Ernst, B., Macedo, M. P., Colabufo, N. & Rauter, A. P., Jul 2019, In : Pure and Applied Chemistry. 91, 7, p. 1209-1221

Research output: Contribution to journalArticle

Resveratrol
Glycosides
Molecules
Bioactivity
Esters

Data on metabolic profile of insulin-degrading enzyme knockout mice

Borges, D. O., Meneses, M. J., Dias, T. R., Martins, F. O., Oliveira, P. F., Alves, M. G. & Macedo, M. P., 1 Aug 2019, In : Data in brief. 25, 104023.

Research output: Contribution to journalArticle

Open Access
File
Insulysin
Metabolome
Knockout Mice
Insulin
Glucose

Design and Synthesis of CNb-targeted Flavones and Analogues with Neuroprotective Potential Against H2O2- and Aβ1-42-Induced Toxicity in SH-SY5Y Human Neuroblastoma Cells

Matos, A. M. D., Martins, A., Man, T., Evans, D., Walter, M., Oliveira, M. C., López, Ó., Fernandez-Bolaños, J. G., Dätwyler, P., Ernst, B., Macedo, M. P., Contino, M., Colabufo, N. A. & Rauter, A. P., 1 Jun 2019, In : Pharmaceuticals. 12, 2, 98.

Research output: Contribution to journalArticle

Open Access
File
Flavones
Aptitude
Neuroprotective Agents
Neuroblastoma
Permeability

Determining contributions of exogenous glucose and fructose to de novo fatty acid and glycerol synthesis in liver and adipose tissue

Silva, J. C. P., Marques, C., Martins, F. O., Viegas, I., Tavares, L., Macedo, M. P. & Jones, J. G., 1 Dec 2019, In : Metabolic Engineering. 56, p. 69-76 8 p.

Research output: Contribution to journalArticle

Open Access
Lipogenesis
Fructose
Glycerol
Fatty acids
Liver
1 Citation (Scopus)

Knockout of insulin-degrading enzyme leads to mice testicular morphological changes and impaired sperm quality

Meneses, M. J., Borges, D. O., Dias, T. R., Martins, F. O., Oliveira, P. F., Macedo, M. P. & Alves, M. G., Apr 2019, In : Molecular and Cellular Endocrinology. 486, p. 11-17

Research output: Contribution to journalArticle

Insulysin
Spermatozoa
Knockout Mice
Insulin
Tissue
1 Downloads (Pure)

Dipeptidyl Peptidase-4 Is a Pro-Recovery Mediator During Acute Hepatotoxic Damage and Mirrors Severe Shifts in Kupffer Cells

Duarte, N., Coelho, I., Holovanchuk, D., Inês Almeida, J., Penha-Gonçalves, C. & Paula Macedo, M., Sep 2018, In : Hepatology communications. 2, 9, p. 1080-1094 15 p.

Research output: Contribution to journalArticle

Open Access
File
Dipeptidyl Peptidase 4
Kupffer Cells
Liver
Clodronic Acid
Serum
Diabetic Nephropathies
Inflammation
Environmental Monitoring
Xenobiotics
Cysteine
4 Citations (Scopus)
3 Downloads (Pure)

Rho-kinase/AMPK axis regulates hepatic lipogenesis during overnutrition

Huang, H., Lee, S. H., Sousa-Lima, I., Kim, S. S., Hwang, W. M., Dagon, Y., Yang, W. M., Cho, S., Kang, M. C., Seo, J. A., Shibata, M., Cho, H., Belew, G. D., Bhin, J., Desai, B. N., Ryu, M. J., Shong, M., Li, P., Meng, H., Chung, B. H. & 7 othersHwang, D., Kim, M. S., Park, K. S., Macedo, M. P., White, M., Jones, J. & Kim, Y. B., 3 Dec 2018, In : Journal of Clinical Investigation. 128, 12, p. 5335-5350 16 p.

Research output: Contribution to journalArticle

Open Access
File
Overnutrition
rho-Associated Kinases
Lipogenesis
AMP-Activated Protein Kinases
Liver
2017

Genetic control of glucose tolerance and insulin secretion by CD26/DPP4 is abrogated in prediabetes

Patarrao, R. S., Duarte, N., Raposo, J. F., Costa, J., Ribeiro, R. T., Gardete-Correia, L., Duarte, R., Boavida, J. M., Correia, I., Andrade, R., Medina, J., Penha-Goncalves, C. & Macedo, M. P., Sep 2017, In : Diabetologia. 60, p. S176-S176 1 p.

Research output: Contribution to journalArticle

3 Citations (Scopus)

Mutant A53T α-Synuclein Improves Rotarod Performance Before Motor Deficits and Affects Metabolic Pathways

Guerreiro, P. S., Coelho, J. E., Sousa-Lima, I., Macedo, M. P., Lopes, L. V., Outeiro, T. F. & Pais, T. F., 1 Mar 2017, In : NeuroMolecular Medicine. 19, 1, p. 1-9 9 p.

Research output: Contribution to journalArticle

Synucleins
Metabolic Networks and Pathways
Sirtuin 2
Transgenic Mice
Weight Loss
2016
6 Citations (Scopus)

Diabetes hinders community-acquired pneumonia outcomes in hospitalized patients

Martins, M., Boavida, J. M., Raposo, J. F., Froes, F., Nunes, B., Ribeiro, R. T., Macedo, M. P. & Penha-Goncalves, C., Feb 2016, In : BMJ OPEN DIABETES RESEARCH CARE. 4, 1, e000181.

Research output: Contribution to journalArticle

Pneumonia
Diabetes Mellitus
Length of Stay
Hospital Mortality
Hospitalization
1 Citation (Scopus)

Direct analysis of [6,6-H-2(2)]glucose and [U-C-13(6)]glucose dry blood spot enrichments by LC-MS/MS

Coelho, M., Mendes, V. M., Lima, I. S., Martins, F. O., Fernandes, A. B., Macedo, M. P., Jones, J. G. & Manadas, B., 1 Jun 2016, In : Journal of Chromatography B. 1022, p. 242-248 7 p.

Research output: Contribution to journalArticle

Blood Glucose
Glucose
Tandem Mass Spectrometry
Liquid Chromatography
15 Citations (Scopus)
Fructosamine
Prediabetic State
Glucose
Glucose Intolerance
Glycosylated Hemoglobin A
35 Citations (Scopus)

Inside the Diabetic Brain: Role of Different Players Involved in Cognitive Decline

Gaspar, J. M., Baptista, F. I., Macedo, M. P. & Ambrosio, A. F., Feb 2016, In : Acs Chemical Neuroscience. 7, 2, p. 131-142 12 p.

Research output: Contribution to journalArticle

Liver-specific deletion of ROCK1 prevents hepatic steatosis in leptin-deficient ob/ob mice

Lima, I. S., Lee, J. S. H., Huang, H., Chung, M., Macedo, M. P. & Kim, Y-T. Y-B. B. T., Aug 2016, In : Diabetologia. 59, p. S308-S308 1 p.

Research output: Contribution to journalArticle

5 Citations (Scopus)

Mechanisms by which the thiazolidinedione troglitazone protects against sucrose-induced hepatic fat accumulation and hyperinsulinaemia

Martins, F. P. D. C. O., Delgado, T. C., Viegas, J., Gaspar, J. M., Scott, D. K., O'Doherty, R. M., Macedo, M. P. & Jones, J. G., Jan 2016, In : British Journal of Pharmacology. 173, 2, p. 267-278 12 p.

Research output: Contribution to journalArticle

4 Citations (Scopus)

Methylsulfonylmethane (MSM), an organosulfur compound, is effective against obesity-induced metabolic disorders in mice

Lima, I. S., Park, S-Y., Chung, M., Jung, H. J., Kang, M-C. C., Gaspar, J. M., Seo, J. A., Macedo, M. P., Park, K. S., Mantzoros, C., Lee, S-H. & Kim, Y-T. Y-B. B. T., Oct 2016, In : Metabolism-Clinical And Experimental. 65, 10, p. 1508-1521 14 p.

Research output: Contribution to journalArticle

Obesity
Obese Mice
Diet
Glucose
dimethyl sulfone
2015
4 Citations (Scopus)
2 Downloads (Pure)

Acute glucagon induces postprandial peripheral insulin resistance

Patarrão, R. S. & Macedo, M. P., 1 Jan 2015, In : PLoS ONE. 10, 5, p. Online

Research output: Contribution to journalArticle

Open Access
File
glucagon
Glucagon
insulin resistance
Vascular Resistance
Insulin Resistance
16 Citations (Scopus)

Mechanisms through which a small protein and lipid preload improves glucose tolerance

Macedo, M. P., Nov 2015, In : Diabetologia. 58, 11, p. 2503-2512

Research output: Contribution to journalArticle

2014
21 Citations (Scopus)

Exploiting the Therapeutic Potential of 8-beta-D-Glucopyranosylgenistein: Synthesis, Antidiabetic Activity, and Molecular Interaction with Islet Amyloid Polypeptide and Amyloid beta-Peptide (1-42)

Jesus, A. R., Dias, C., Matos, A. M., de Almeida, R. F. M., Viana, A. S., Marcelo, F. M. B. M., Ribeiro, R. T., Macedo, M. P., Airoldi, C., Nicotra, F., Martins, A., Cabrita, E. J., Jimenez-Barbere, J. & Rauter, A. P., 27 Nov 2014, In : Journal Of Medicinal Chemistry. 57, 22, p. 9463-9472 10 p.

Research output: Contribution to journalArticle

Islet Amyloid Polypeptide
Hypoglycemic Agents
Amyloid
Genista
Atomic Force Microscopy
10 Citations (Scopus)

NOS2 variants reveal a dual genetic control of nitric oxide levels, susceptibility to Plasmodium infection, and cerebral malaria

de Jesus Trovoada, M., Martins, M., Mansour, R. B., Do Rosário Sambo, M., Fernandes, A. B., Gonçalves, L. A., Borja, A., Moya, R., Almeida, P., Costa, J., Marques, I., Paula Macedo, M., Coutinho, A., Narum, D. L. & Penha-Gonçalves, C., 1 Mar 2014, In : Infection and Immunity. 82, 3, p. 1287-1295 9 p.

Research output: Contribution to journalArticle

Plasmodium malariae
Cerebral Malaria
Malaria
Nitric Oxide
Biological Availability
2013
7 Citations (Scopus)
Liver Glycogen
Glucose
Transaldolase
Glucose-6-Phosphate
Body Water
26 Citations (Scopus)
2 Downloads (Pure)
Open Access
File
Continuous Positive Airway Pressure
Sleep Apnea Syndromes
Obstructive Sleep Apnea
Nitrates
Norepinephrine
8 Citations (Scopus)
Liver Glycogen
Fructose
Glycogen
Trioses
Glucose
8 Citations (Scopus)
Insulin Resistance
Liver
Glucose
Food
Aptitude
17 Citations (Scopus)
Nitric Oxide
Insulin
Glucose
NG-Nitroarginine Methyl Ester
Glucose Tolerance Test
2012
4 Citations (Scopus)
Insulin Resistance
Fasting
Insulin
Meals
Glucose
6 Citations (Scopus)
Insulin Resistance
Nitric Oxide
Insulin
Glucose
Nitric Oxide Synthase
3 Citations (Scopus)
S-Nitrosothiols
Insulin Resistance
Insulin
S-Nitroso-N-Acetylpenicillamine
Liver
2010
13 Citations (Scopus)
4 Downloads (Pure)

High-fat diet results in postprandial insulin resistance that involves parasympathetic dysfunction

Afonso, R. A., Lautt, W. W., Schafer, J., Legare, D. J., Oliveira, A. G. & Macedo, M. P., 1 Jan 2010, In : British Journal Of Nutrition. 104, 10, p. 1450-1459

Research output: Contribution to journalArticle

Open Access
File
22 Citations (Scopus)
Meals
Insulin Resistance
Insulin
Atropine
Glucose Clamp Technique
2007
9 Citations (Scopus)
Insulin Resistance
Glucose
Meals
Insulin
Glucose Clamp Technique
11 Citations (Scopus)
Insulin Resistance
Animal Models
Insulin
Hypertension
Liver
5 Citations (Scopus)
Zucker Rats
High Fat Diet
Insulin Resistance
Animal Models
Obesity
2006
29 Citations (Scopus)
Nitric Oxide
NG-Nitroarginine Methyl Ester
Arterial Pressure
Nitric Oxide Synthase
Hemodynamics
27 Citations (Scopus)
Glutathione
Insulin Resistance
Wistar Rats
Nitric Oxide
Liver
2 Citations (Scopus)
insulin
Insulin
nitric oxide
Nitric Oxide
S-Nitrosothiols
22 Citations (Scopus)
3 Downloads (Pure)

Meal-induced insulin sensitization in conscious and anaesthetized rat models comparing liquid mixed meal with glucose and sucrose

Sadri, P., Reid, M. A. G., Afonso, R. A., Schafer, J., Legare, D. J., Macedo, M. P. & Lautt, W. W., Feb 2006, In : British Journal Of Nutrition. 95, 2, p. 288-295 8 p.

Research output: Contribution to journalArticle

Open Access
File
Meals
Sucrose
Insulin
Glucose
Stomach
2005
50 Citations (Scopus)
39 Citations (Scopus)

Insulin sensitivity is mediated by the activation of the ACh/NO/cGMP pathway in rat liver

Guarino, M. P., Correia, N. C., Lautt, W. W. & Macedo, M. P., 1 Sep 2004, In : American Journal of Physiology - Gastrointestinal and Liver Physiology. 287, 3 50-3, p. G527–G532

Research output: Contribution to journalArticle

Insulin Resistance
Nitric Oxide
Liver
Insulin
NG-Nitroarginine Methyl Ester