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Research Output at NOVA 1998 2020

2020

Clustering Clinical Data in R

Pina, A., Macedo, M. P. & Henriques, R., 1 Jan 2020, In : Methods In Molecular Biology (Clifton, N.J.). 2051, p. 309-343 35 p.

Research output: Contribution to journalArticle

Cluster Analysis
Data Mining
Precision Medicine
Evidence-Based Medicine
Software
2019

2-Deoxyglycosylation towards more effective and bioavailable neuroprotective molecules inspired by nature

Dias, C., Matos, A. M., Blásquez-Sanchez, M. T., Calado, P., Martins, A., Dätwyler, P., Ernst, B., Macedo, M. P., Colabufo, N. & Rauter, A. P., Jul 2019, In : Pure and Applied Chemistry. 91, 7, p. 1209-1221

Research output: Contribution to journalArticle

Resveratrol
Glycosides
Molecules
Bioactivity
Esters

Data on metabolic profile of insulin-degrading enzyme knockout mice

Borges, D. O., Meneses, M. J., Dias, T. R., Martins, F. O., Oliveira, P. F., Alves, M. G. & Macedo, M. P., 1 Aug 2019, In : Data in brief. 25, 104023.

Research output: Contribution to journalArticle

Open Access
File
Insulysin
Metabolome
Knockout Mice
Insulin
Glucose

Design and Synthesis of CNb-targeted Flavones and Analogues with Neuroprotective Potential Against H2O2- and Aβ1-42-Induced Toxicity in SH-SY5Y Human Neuroblastoma Cells

Matos, A. M. D., Martins, A., Man, T., Evans, D., Walter, M., Oliveira, M. C., López, Ó., Fernandez-Bolaños, J. G., Dätwyler, P., Ernst, B., Macedo, M. P., Contino, M., Colabufo, N. A. & Rauter, A. P., 1 Jun 2019, In : Pharmaceuticals. 12, 2, 98.

Research output: Contribution to journalArticle

Open Access
File
Flavones
Aptitude
Neuroprotective Agents
Neuroblastoma
Permeability

Determining contributions of exogenous glucose and fructose to de novo fatty acid and glycerol synthesis in liver and adipose tissue

Silva, J. C. P., Marques, C., Martins, F. O., Viegas, I., Tavares, L., Macedo, M. P. & Jones, J. G., 1 Dec 2019, In : Metabolic Engineering. 56, p. 69-76 8 p.

Research output: Contribution to journalArticle

Open Access
Lipogenesis
Fructose
Glycerol
Fatty acids
Liver

Fructose contributes more to the synthesis of saturated fatty acids than it does to oleate in the liver

Jones, J., Silva, J., Martins, F., Viegas, I., Marques, C. & Macedo, M. P., Apr 2019, In : European Journal Of Clinical Investigation. 49, p. 213-214

Research output: Contribution to journalMeeting Abstract

1 Citation (Scopus)

Knockout of insulin-degrading enzyme leads to mice testicular morphological changes and impaired sperm quality

Meneses, M. J., Borges, D. O., Dias, T. R., Martins, F. O., Oliveira, P. F., Macedo, M. P. & Alves, M. G., Apr 2019, In : Molecular and Cellular Endocrinology. 486, p. 11-17

Research output: Contribution to journalArticle

Insulysin
Spermatozoa
Knockout Mice
Insulin
Tissue

Metabolic fluxes of human urine-derived cells are comparable in young and old donors

Bento, G., Sardao, V. A., Macedo, P. & Oliveira, P. J., Apr 2019, In : European Journal Of Clinical Investigation. 49, p. 106-106

Research output: Contribution to journalMeeting Abstract

Open Access
File
Aryldialkylphosphatase
homeostasis
Oxidative stress
regulators
antioxidants
2018

ApoJ/clusterin serum levels in patients with impaired glucose tolerance

Meneses, M. J., Sousa-Lima, I., Patarrao, R. S., Ribeiro, R. T., Gardete-Correia, L., Duarte, R., Boavida, J. M., Correia, I., Andrade, R., Medina, J. L., Jones, J., Raposo, J. F. & Paula Macedo, M., Jun 2018, In : European Journal Of Clinical Investigation. 48, p. 63-64

Research output: Contribution to journalMeeting Abstract

Circular dorsal ruffles and IR internalisation

Araujo-Correia, M., de Oliveira, R. M., Barral, D. C. & Macedo, M., Oct 2018, In : Diabetologia. 61, p. S83-S83

Research output: Contribution to journalMeeting Abstract

1 Downloads (Pure)

Dipeptidyl Peptidase-4 Is a Pro-Recovery Mediator During Acute Hepatotoxic Damage and Mirrors Severe Shifts in Kupffer Cells

Duarte, N., Coelho, I., Holovanchuk, D., Inês Almeida, J., Penha-Gonçalves, C. & Paula Macedo, M., Sep 2018, In : Hepatology communications. 2, 9, p. 1080-1094 15 p.

Research output: Contribution to journalArticle

Open Access
File
Dipeptidyl Peptidase 4
Kupffer Cells
Liver
Clodronic Acid
Serum

Fructose contributions to hepatic triglyceride synthesis in the presence of glucose during overnight feeding in mice

Jones, J., Silva, J., Martins, F., Viegas, I., Marques, C. & Macedo, M., Oct 2018, In : Diabetologia. 61, p. S227-S228

Research output: Contribution to journalMeeting Abstract

Human urine-derived cells for assessing metabolic profile and mitochondrial morphology in young and old donors

Bento, G., Oliveira, P. J., Macedo, M. P. & Sardao, V. A., Jun 2018, In : European Journal Of Clinical Investigation. 48, p. 52-53

Research output: Contribution to journalMeeting Abstract

Diabetic Nephropathies
Inflammation
Environmental Monitoring
Xenobiotics
Cysteine
4 Citations (Scopus)
3 Downloads (Pure)

Rho-kinase/AMPK axis regulates hepatic lipogenesis during overnutrition

Huang, H., Lee, S. H., Sousa-Lima, I., Kim, S. S., Hwang, W. M., Dagon, Y., Yang, W. M., Cho, S., Kang, M. C., Seo, J. A., Shibata, M., Cho, H., Belew, G. D., Bhin, J., Desai, B. N., Ryu, M. J., Shong, M., Li, P., Meng, H., Chung, B. H. & 7 othersHwang, D., Kim, M. S., Park, K. S., Macedo, M. P., White, M., Jones, J. & Kim, Y. B., 3 Dec 2018, In : Journal of Clinical Investigation. 128, 12, p. 5335-5350 16 p.

Research output: Contribution to journalArticle

Open Access
File
Overnutrition
rho-Associated Kinases
Lipogenesis
AMP-Activated Protein Kinases
Liver
2017

BACE2 suppression prevents weight gain in mice fed with high-fat diet

Alcarraz-Vizan, G., Castano, C., Fernandez-Perez, A., Viegas, J., Macedo, M. P., Vallejo, M., Parrizas, M., Servitja, J. -M. & Novials, A., Sep 2017, In : Diabetologia. 60, p. S263-S263

Research output: Contribution to journalMeeting Abstract

Differential contribution of glucose to triglyceride lipogenesis in visceral adipose tissue and liver following glucose/fructose supplementation

Jones, J. G., Silva, J., Marques, C., Viegas, I., Martins, F. & Macedo, M. P., Sep 2017, In : Diabetologia. 60, p. S267-S267 1 p.

Research output: Contribution to journalMeeting Abstract

Differential fractional synthetic and elongation rates of hepatic saturated fatty acids and oleate from dietary [U-13C]glucose in healthy mice

Silva, J., Martins, F., Marques, C., Macedo, M. P., Viegas, I. & Jones, J., Sep 2017, In : Diabetologia. 60, p. S268-S268 1 p.

Research output: Contribution to journalMeeting Abstract

From mouse and man: the insulin-degrading enzyme gene governs insulin clearance and drives glucose intolerance and NAFLD development

Borges, D. O., Patarrao, R. S., Raposo, J. F., Martins, F. O., Martins, M., Ribeiro, R. T., Gardete-Correia, L., Duarte, R., Boavida, J. M., Correia, I., Andrade, R., Medina, J. L., Costa, J., Goncalves, C. P. & Macedo, M. P., Sep 2017, In : Diabetologia. 60, p. S212-S213 2 p.

Research output: Contribution to journalMeeting Abstract

Genetic control of glucose tolerance and insulin secretion by CD26/DPP4 is abrogated in prediabetes

Patarrao, R. S., Duarte, N., Raposo, J. F., Costa, J., Ribeiro, R. T., Gardete-Correia, L., Duarte, R., Boavida, J. M., Correia, I., Andrade, R., Medina, J., Penha-Goncalves, C. & Macedo, M. P., Sep 2017, In : Diabetologia. 60, p. S176-S176 1 p.

Research output: Contribution to journalArticle

Mesenchymal stromal cells from the umbilical cord (UCX (R)): A role in protection against non-alcoholic fatty liver disease?

Lima, I. S., Meneses, M. J., Ferreira, I., Cruz, H., Santos, J. M. & Macedo, M. P., Sep 2017, In : Diabetologia. 60, p. S398-S399 2 p.

Research output: Contribution to journalMeeting Abstract

3 Citations (Scopus)

Mutant A53T α-Synuclein Improves Rotarod Performance Before Motor Deficits and Affects Metabolic Pathways

Guerreiro, P. S., Coelho, J. E., Sousa-Lima, I., Macedo, M. P., Lopes, L. V., Outeiro, T. F. & Pais, T. F., 1 Mar 2017, In : NeuroMolecular Medicine. 19, 1, p. 1-9 9 p.

Research output: Contribution to journalArticle

Synucleins
Metabolic Networks and Pathways
Sirtuin 2
Transgenic Mice
Weight Loss

Visceral adipose tissue of healthy male mice shows active de novo lipogenesis during both short-term and long-term high-sugar feeding

Marques, C., Silva, J., Viegas, I., Martins, F., Macedo, M. P. & Jones, J., Sep 2017, In : Diabetologia. 60, p. S274-S274 1 p.

Research output: Contribution to journalMeeting Abstract

2016
6 Citations (Scopus)

Diabetes hinders community-acquired pneumonia outcomes in hospitalized patients

Martins, M., Boavida, J. M., Raposo, J. F., Froes, F., Nunes, B., Ribeiro, R. T., Macedo, M. P. & Penha-Goncalves, C., Feb 2016, In : BMJ OPEN DIABETES RESEARCH CARE. 4, 1, e000181.

Research output: Contribution to journalArticle

Pneumonia
Diabetes Mellitus
Length of Stay
Hospital Mortality
Hospitalization
1 Citation (Scopus)

Direct analysis of [6,6-H-2(2)]glucose and [U-C-13(6)]glucose dry blood spot enrichments by LC-MS/MS

Coelho, M., Mendes, V. M., Lima, I. S., Martins, F. O., Fernandes, A. B., Macedo, M. P., Jones, J. G. & Manadas, B., 1 Jun 2016, In : Journal of Chromatography B. 1022, p. 242-248 7 p.

Research output: Contribution to journalArticle

Blood Glucose
Glucose
Tandem Mass Spectrometry
Liquid Chromatography
14 Citations (Scopus)
Fructosamine
Prediabetic State
Glucose
Glucose Intolerance
Glycosylated Hemoglobin A

Hepatic insulin clearance governs primary hyperinsulinaemia in prediabetes progression: a perverse paradox mediated by nitric oxide

Macedo, M. P., Duarte, N., Patarrao, R., Ribeiro, R., Fernandes, A. B., Martins, M., Raposo, J. F., Boavida, J. M., Gardete-Correia, L., Duarte, R., Medina, J. L. & Penha-Goncalves, C., Aug 2016, In : Diabetologia. 59, p. S279-S279 1 p.

Research output: Contribution to journalMeeting Abstract

35 Citations (Scopus)

Inside the Diabetic Brain: Role of Different Players Involved in Cognitive Decline

Gaspar, J. M., Baptista, F. I., Macedo, M. P. & Ambrosio, A. F., Feb 2016, In : Acs Chemical Neuroscience. 7, 2, p. 131-142 12 p.

Research output: Contribution to journalArticle

Liver-specific deletion of ROCK1 prevents hepatic steatosis in leptin-deficient ob/ob mice

Lima, I. S., Lee, J. S. H., Huang, H., Chung, M., Macedo, M. P. & Kim, Y-T. Y-B. B. T., Aug 2016, In : Diabetologia. 59, p. S308-S308 1 p.

Research output: Contribution to journalArticle

5 Citations (Scopus)

Mechanisms by which the thiazolidinedione troglitazone protects against sucrose-induced hepatic fat accumulation and hyperinsulinaemia

Martins, F. P. D. C. O., Delgado, T. C., Viegas, J., Gaspar, J. M., Scott, D. K., O'Doherty, R. M., Macedo, M. P. & Jones, J. G., Jan 2016, In : British Journal of Pharmacology. 173, 2, p. 267-278 12 p.

Research output: Contribution to journalArticle

4 Citations (Scopus)

Methylsulfonylmethane (MSM), an organosulfur compound, is effective against obesity-induced metabolic disorders in mice

Lima, I. S., Park, S-Y., Chung, M., Jung, H. J., Kang, M-C. C., Gaspar, J. M., Seo, J. A., Macedo, M. P., Park, K. S., Mantzoros, C., Lee, S-H. & Kim, Y-T. Y-B. B. T., Oct 2016, In : Metabolism-Clinical And Experimental. 65, 10, p. 1508-1521 14 p.

Research output: Contribution to journalArticle

Obesity
Obese Mice
Diet
Glucose
dimethyl sulfone

Reversion from prediabetes to normal metabolism is positively correlated with a loss of body weight in a nationwide observational population study

Ribeiro, R. T., Raposo, J. E., Boavida, J. M., Macedo, M. P., Correia, I., Andrade, R., Silva, A., Duarte, R., Medina, J. L. & Gardete-Correia, L., Aug 2016, In : Diabetologia. 59, p. S152-S153 2 p.

Research output: Contribution to journalMeeting Abstract

2015
4 Citations (Scopus)
2 Downloads (Pure)

Acute glucagon induces postprandial peripheral insulin resistance

Patarrão, R. S. & Macedo, M. P., 1 Jan 2015, In : PLoS ONE. 10, 5, p. Online

Research output: Contribution to journalArticle

Open Access
File
glucagon
Glucagon
insulin resistance
Vascular Resistance
Insulin Resistance
35 Citations (Scopus)
2 Downloads (Pure)

How inflammation impinges on NAFLD: A role for Kupffer cells

Duarte, N., Coelho, I. C., Patarrão, R. S., Almeida, J. I., Gonçalves, C. P. & Macedo, M. P., 2015, In : BioMed Research International. 984578, NA, p. Online 11 p.

Research output: Contribution to journalReview article

Open Access
File
Kupffer Cells
Liver
Inflammation
Insulin Resistance
Liver Diseases

Insulin-sensitising effects of methysulfonly methane (MSM), an organosulfur compound, in insulin-resistant obese mice

Macedo, M. P. B. D. L., 1 Jan 2015, 233 SPRING ST, NEW YORK, NY 10013 USA : Springer.

Research output: Other contribution

16 Citations (Scopus)

Mechanisms through which a small protein and lipid preload improves glucose tolerance

Macedo, M. P., Nov 2015, In : Diabetologia. 58, 11, p. 2503-2512

Research output: Contribution to journalArticle

Role of circular dorsal ruffles in the internalisation of the insulin receptor

Portelinha, A. C. C., Macedo, M. P. B. D. L. & Barral, D. C. F., 1 Jan 2015, 233 SPRING ST, NEW YORK, NY 10013 USA : Springer.

Research output: Other contribution

2014

Bridges in translational medicine: a case for metabolism, inflammation, and nutrition

Macedo, MP., 2014, In : Canadian Journal Of Physiology And Pharmacology. 92, 8, p. 3-3 1 p.

Research output: Contribution to journalBook/Film/Article review

21 Citations (Scopus)

Exploiting the Therapeutic Potential of 8-beta-D-Glucopyranosylgenistein: Synthesis, Antidiabetic Activity, and Molecular Interaction with Islet Amyloid Polypeptide and Amyloid beta-Peptide (1-42)

Jesus, A. R., Dias, C., Matos, A. M., de Almeida, R. F. M., Viana, A. S., Marcelo, F. M. B. M., Ribeiro, R. T., Macedo, M. P., Airoldi, C., Nicotra, F., Martins, A., Cabrita, E. J., Jimenez-Barbere, J. & Rauter, A. P., 27 Nov 2014, In : Journal Of Medicinal Chemistry. 57, 22, p. 9463-9472 10 p.

Research output: Contribution to journalArticle

Islet Amyloid Polypeptide
Hypoglycemic Agents
Amyloid
Genista
Atomic Force Microscopy

Glucose uptake independent of insulin action: role of S-nitrosilated insulin chains

Lima, I. S., Gaspar, J. M. N. & Macedo, M. P. B. D. L., 1 Jan 2014, 233 SPRING ST, NEW YORK, NY 10013 USA : Springer.

Research output: Other contribution