• 1027 Citations
  • 19 h-Index
19982020

Research output per year

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Research Output at NOVA

2020

Clustering clinical data in R

Pina, A., Macedo, M. P. & Henriques, R., 2020, Methods in Molecular Biology. Humana Press Inc, Vol. 2051. p. 309-343 35 p. (Methods in Molecular Biology; vol. 2051).

Research output: Chapter in Book/Report/Conference proceedingChapter

Urine-Derived Stem Cells: Applications in Regenerative and Predictive Medicine

Bento, G., Shafigullina, A. K., Rizvanov, A. A., Sardão, V. A., Macedo, M. P. & Oliveira, P. J., 28 Feb 2020, In : Cells. 9, 3

Research output: Contribution to journalReview article

Open Access
File

Virtual genetic diagnosis for familial hypercholesterolemia powered by machine learning

Pina, A., Helgadottir, S., Mancina, R. M., Pavanello, C., Pirazzi, C., Montalcini, T., Henriques, R., Calabresi, L., Wiklund, O., Macedo, M. P., Valenti, L., Volpe, G. & Romeo, S., 2020, In : European Journal of Preventive Cardiology.

Research output: Contribution to journalArticle

1 Citation (Scopus)
2019

27th Annual Meeting of the European Group for the study of Insulin Resistance, Lisbon, Portugal, 8-9th May 2019

Bonner, C., Jones, J., Paula Macedo, M. & Gastaldelli, A., Sep 2019, In : Cardiovascular endocrinology & metabolism. 8, 3, p. 88-89 2 p.

Research output: Contribution to journalArticle

2-Deoxyglycosylation towards more effective and bioavailable neuroprotective molecules inspired by nature

Dias, C., Matos, A. M., Blásquez-Sanchez, M. T., Calado, P., Martins, A., Dätwyler, P., Ernst, B., Macedo, M. P., Colabufo, N. & Rauter, A. P., Jul 2019, In : Pure and Applied Chemistry. 91, 7, p. 1209-1221

Research output: Contribution to journalArticle

Data on metabolic profile of insulin-degrading enzyme knockout mice

Borges, D. O., Meneses, M. J., Dias, T. R., Martins, F. O., Oliveira, P. F., Alves, M. G. & Macedo, M. P., 1 Aug 2019, In : Data in brief. 25, 104023.

Research output: Contribution to journalArticle

Open Access
File
5 Downloads (Pure)

Design and Synthesis of CNb-targeted Flavones and Analogues with Neuroprotective Potential Against H2O2- and Aβ1-42-Induced Toxicity in SH-SY5Y Human Neuroblastoma Cells

Matos, A. M. D., Martins, A., Man, T., Evans, D., Walter, M., Oliveira, M. C., López, Ó., Fernandez-Bolaños, J. G., Dätwyler, P., Ernst, B., Macedo, M. P., Contino, M., Colabufo, N. A. & Rauter, A. P., 1 Jun 2019, In : Pharmaceuticals. 12, 2, 98.

Research output: Contribution to journalArticle

Open Access
File

Determining contributions of exogenous glucose and fructose to de novo fatty acid and glycerol synthesis in liver and adipose tissue

Silva, J. C. P., Marques, C., Martins, F. O., Viegas, I., Tavares, L., Macedo, M. P. & Jones, J. G., 1 Dec 2019, In : Metabolic Engineering. 56, p. 69-76 8 p.

Research output: Contribution to journalArticle

2 Citations (Scopus)

Fructose contributes more than glucose to hepatic de novo synthesis of saturated fatty acids and oleate

Jones, J., Silva, J., Martins, F., Viegas, I., Marques, C. & Macedo, M., Sep 2019, In : Diabetologia. 62, p. S264-S265

Research output: Contribution to journalMeeting Abstract

Fructose contributes more to the synthesis of saturated fatty acids than it does to oleate in the liver

Jones, J., Silva, J., Martins, F., Viegas, I., Marques, C. & Macedo, M. P., Apr 2019, In : European Journal Of Clinical Investigation. 49, p. 213-214

Research output: Contribution to journalMeeting Abstract

Hyperinsulinaemia decreases insulin receptor internalisation mediated by circular dorsal ruffles

de Oliveira, R. M., Correia, M. A., de Oliveira, L. M., Barral, D. C. & Macedo, M. P., Sep 2019, In : Diabetologia. 62, p. S103-S103

Research output: Contribution to journalMeeting Abstract

Knockout of insulin-degrading enzyme leads to mice testicular morphological changes and impaired sperm quality

Meneses, M. J., Borges, D. O., Dias, T. R., Martins, F. O., Oliveira, P. F., Macedo, M. P. & Alves, M. G., Apr 2019, In : Molecular and Cellular Endocrinology. 486, p. 11-17

Research output: Contribution to journalArticle

2 Citations (Scopus)

Liver IDE deficiency is a risk factor for nonalcoholic fatty liver disease and prediabetes development

Borges, D. O., Ribeiro, R. T., Penha-Goncalves, C. & Macedo, M. P., Sep 2019, In : Diabetologia. 62, p. S302-S303

Research output: Contribution to journalMeeting Abstract

2 Citations (Scopus)

Metabolic fluxes of human urine-derived cells are comparable in young and old donors

Bento, G., Sardao, V. A., Macedo, P. & Oliveira, P. J., Apr 2019, In : European Journal Of Clinical Investigation. 49, p. 106-106

Research output: Contribution to journalMeeting Abstract

Open Access
File
3 Citations (Scopus)
2 Downloads (Pure)

Transfer of glucose hydrogens via acetyl-CoA, malonyl-CoA, and NADPH to fatty acids during de novo lipogenesis

Belew, G. D., Silva, J., Rito, J., Tavares, L., Viegas, I., Teixeira, J., Oliveira, P. J., Macedo, M. P. & Jones, J. G., 1 Dec 2019, In : Journal Of Lipid Research. 60, 12, p. 2050-2056 7 p.

Research output: Contribution to journalArticle

2018

ApoJ/clusterin serum levels in patients with impaired glucose tolerance

Meneses, M. J., Sousa-Lima, I., Patarrao, R. S., Ribeiro, R. T., Gardete-Correia, L., Duarte, R., Boavida, J. M., Correia, I., Andrade, R., Medina, J. L., Jones, J., Raposo, J. F. & Paula Macedo, M., Jun 2018, In : European Journal Of Clinical Investigation. 48, p. 63-64

Research output: Contribution to journalMeeting Abstract

Circular dorsal ruffles and IR internalisation

Araujo-Correia, M., de Oliveira, R. M., Barral, D. C. & Macedo, M., Oct 2018, In : Diabetologia. 61, p. S83-S83

Research output: Contribution to journalMeeting Abstract

Dipeptidyl Peptidase-4 Is a Pro-Recovery Mediator During Acute Hepatotoxic Damage and Mirrors Severe Shifts in Kupffer Cells

Duarte, N., Coelho, I., Holovanchuk, D., Inês Almeida, J., Penha-Gonçalves, C. & Paula Macedo, M., Sep 2018, In : Hepatology communications. 2, 9, p. 1080-1094 15 p.

Research output: Contribution to journalArticle

Open Access
File
1 Downloads (Pure)

Fructose contributions to hepatic triglyceride synthesis in the presence of glucose during overnight feeding in mice

Jones, J., Silva, J., Martins, F., Viegas, I., Marques, C. & Macedo, M., Oct 2018, In : Diabetologia. 61, p. S227-S228

Research output: Contribution to journalMeeting Abstract

Human urine-derived cells for assessing metabolic profile and mitochondrial morphology in young and old donors

Bento, G., Oliveira, P. J., Macedo, M. P. & Sardao, V. A., Jun 2018, In : European Journal Of Clinical Investigation. 48, p. 52-53

Research output: Contribution to journalMeeting Abstract

Rho-kinase/AMPK axis regulates hepatic lipogenesis during overnutrition

Huang, H., Lee, S. H., Sousa-Lima, I., Kim, S. S., Hwang, W. M., Dagon, Y., Yang, W. M., Cho, S., Kang, M. C., Seo, J. A., Shibata, M., Cho, H., Belew, G. D., Bhin, J., Desai, B. N., Ryu, M. J., Shong, M., Li, P., Meng, H., Chung, B. H. & 7 others, Hwang, D., Kim, M. S., Park, K. S., Macedo, M. P., White, M., Jones, J. & Kim, Y. B., 3 Dec 2018, In : Journal of Clinical Investigation. 128, 12, p. 5335-5350 16 p.

Research output: Contribution to journalArticle

Open Access
File
8 Citations (Scopus)
4 Downloads (Pure)
2017

BACE2 suppression prevents weight gain in mice fed with high-fat diet

Alcarraz-Vizan, G., Castano, C., Fernandez-Perez, A., Viegas, J., Macedo, M. P., Vallejo, M., Parrizas, M., Servitja, J. -M. & Novials, A., Sep 2017, In : Diabetologia. 60, p. S263-S263

Research output: Contribution to journalMeeting Abstract

Differential contribution of glucose to triglyceride lipogenesis in visceral adipose tissue and liver following glucose/fructose supplementation

Jones, J. G., Silva, J., Marques, C., Viegas, I., Martins, F. & Macedo, M. P., Sep 2017, In : Diabetologia. 60, p. S267-S267 1 p.

Research output: Contribution to journalMeeting Abstract

Differential fractional synthetic and elongation rates of hepatic saturated fatty acids and oleate from dietary [U-13C]glucose in healthy mice

Silva, J., Martins, F., Marques, C., Macedo, M. P., Viegas, I. & Jones, J., Sep 2017, In : Diabetologia. 60, p. S268-S268 1 p.

Research output: Contribution to journalMeeting Abstract

From mouse and man: the insulin-degrading enzyme gene governs insulin clearance and drives glucose intolerance and NAFLD development

Borges, D. O., Patarrao, R. S., Raposo, J. F., Martins, F. O., Martins, M., Ribeiro, R. T., Gardete-Correia, L., Duarte, R., Boavida, J. M., Correia, I., Andrade, R., Medina, J. L., Costa, J., Goncalves, C. P. & Macedo, M. P., Sep 2017, In : Diabetologia. 60, p. S212-S213 2 p.

Research output: Contribution to journalMeeting Abstract

Genetic control of glucose tolerance and insulin secretion by CD26/DPP4 is abrogated in prediabetes

Patarrao, R. S., Duarte, N., Raposo, J. F., Costa, J., Ribeiro, R. T., Gardete-Correia, L., Duarte, R., Boavida, J. M., Correia, I., Andrade, R., Medina, J., Penha-Goncalves, C. & Macedo, M. P., Sep 2017, In : Diabetologia. 60, p. S176-S176 1 p.

Research output: Contribution to journalArticle

Mesenchymal stromal cells from the umbilical cord (UCX (R)): A role in protection against non-alcoholic fatty liver disease?

Lima, I. S., Meneses, M. J., Ferreira, I., Cruz, H., Santos, J. M. & Macedo, M. P., Sep 2017, In : Diabetologia. 60, p. S398-S399 2 p.

Research output: Contribution to journalMeeting Abstract

Mutant A53T α-Synuclein Improves Rotarod Performance Before Motor Deficits and Affects Metabolic Pathways

Guerreiro, P. S., Coelho, J. E., Sousa-Lima, I., Macedo, M. P., Lopes, L. V., Outeiro, T. F. & Pais, T. F., 1 Mar 2017, In : NeuroMolecular Medicine. 19, 1, p. 1-9 9 p.

Research output: Contribution to journalArticle

4 Citations (Scopus)

Visceral adipose tissue of healthy male mice shows active de novo lipogenesis during both short-term and long-term high-sugar feeding

Marques, C., Silva, J., Viegas, I., Martins, F., Macedo, M. P. & Jones, J., Sep 2017, In : Diabetologia. 60, p. S274-S274 1 p.

Research output: Contribution to journalMeeting Abstract

2016

Diabetes hinders community-acquired pneumonia outcomes in hospitalized patients

Martins, M., Boavida, J. M., Raposo, J. F., Froes, F., Nunes, B., Ribeiro, R. T., Macedo, M. P. & Penha-Goncalves, C., Feb 2016, In : BMJ OPEN DIABETES RESEARCH CARE. 4, 1, e000181.

Research output: Contribution to journalArticle

9 Citations (Scopus)

Direct analysis of [6,6-H-2(2)]glucose and [U-C-13(6)]glucose dry blood spot enrichments by LC-MS/MS

Coelho, M., Mendes, V. M., Lima, I. S., Martins, F. O., Fernandes, A. B., Macedo, M. P., Jones, J. G. & Manadas, B., 1 Jun 2016, In : Journal of Chromatography B. 1022, p. 242-248 7 p.

Research output: Contribution to journalArticle

2 Citations (Scopus)
20 Citations (Scopus)

Hepatic insulin clearance governs primary hyperinsulinaemia in prediabetes progression: a perverse paradox mediated by nitric oxide

Macedo, M. P., Duarte, N., Patarrao, R., Ribeiro, R., Fernandes, A. B., Martins, M., Raposo, J. F., Boavida, J. M., Gardete-Correia, L., Duarte, R., Medina, J. L. & Penha-Goncalves, C., Aug 2016, In : Diabetologia. 59, p. S279-S279 1 p.

Research output: Contribution to journalMeeting Abstract

Inside the Diabetic Brain: Role of Different Players Involved in Cognitive Decline

Gaspar, J. M., Baptista, F. I., Macedo, M. P. & Ambrosio, A. F., Feb 2016, In : Acs Chemical Neuroscience. 7, 2, p. 131-142 12 p.

Research output: Contribution to journalArticle

38 Citations (Scopus)

Liver-specific deletion of ROCK1 prevents hepatic steatosis in leptin-deficient ob/ob mice

Lima, I. S., Lee, J. S. H., Huang, H., Chung, M., Macedo, M. P. & Kim, Y-T. Y-B. B. T., Aug 2016, In : Diabetologia. 59, p. S308-S308 1 p.

Research output: Contribution to journalArticle

Mechanisms by which the thiazolidinedione troglitazone protects against sucrose-induced hepatic fat accumulation and hyperinsulinaemia

Martins, F. P. D. C. O., Delgado, T. C., Viegas, J., Gaspar, J. M., Scott, D. K., O'Doherty, R. M., Macedo, M. P. & Jones, J. G., Jan 2016, In : British Journal of Pharmacology. 173, 2, p. 267-278 12 p.

Research output: Contribution to journalArticle

6 Citations (Scopus)

Methylsulfonylmethane (MSM), an organosulfur compound, is effective against obesity-induced metabolic disorders in mice

Lima, I. S., Park, S-Y., Chung, M., Jung, H. J., Kang, M-C. C., Gaspar, J. M., Seo, J. A., Macedo, M. P., Park, K. S., Mantzoros, C., Lee, S-H. & Kim, Y-T. Y-B. B. T., Oct 2016, In : Metabolism-Clinical And Experimental. 65, 10, p. 1508-1521 14 p.

Research output: Contribution to journalArticle

6 Citations (Scopus)

Reversion from prediabetes to normal metabolism is positively correlated with a loss of body weight in a nationwide observational population study

Ribeiro, R. T., Raposo, J. E., Boavida, J. M., Macedo, M. P., Correia, I., Andrade, R., Silva, A., Duarte, R., Medina, J. L. & Gardete-Correia, L., Aug 2016, In : Diabetologia. 59, p. S152-S153 2 p.

Research output: Contribution to journalMeeting Abstract

2015

Acute glucagon induces postprandial peripheral insulin resistance

Patarrão, R. S. & Macedo, M. P., 1 Jan 2015, In : PLoS ONE. 10, 5, p. Online

Research output: Contribution to journalArticle

Open Access
File
6 Citations (Scopus)
3 Downloads (Pure)

How inflammation impinges on NAFLD: A role for Kupffer cells

Duarte, N., Coelho, I. C., Patarrão, R. S., Almeida, J. I., Gonçalves, C. P. & Macedo, M. P., 2015, In : BioMed Research International. 984578, NA, p. Online 11 p.

Research output: Contribution to journalReview article

Open Access
File
40 Citations (Scopus)
8 Downloads (Pure)

Insulin-sensitising effects of methysulfonly methane (MSM), an organosulfur compound, in insulin-resistant obese mice

Lima, I. S., Park, S., Seo, J., Chung, M., Moura, L., Macedo, M. & Kim, Y. -B., Sep 2015, In : Diabetologia. 58, p. S398-S399

Research output: Contribution to journalMeeting Abstract