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  • FCT-NOVA, Campus Caparica, Unidade de Ciências Biomoleculares Aplicadas (UCIBIO)

    2829-516 Caparica

  • FCT-NOVA, Faculdade de Ciências e Tecnologia, Campus Caparica, Departamento de Química

    2829-516 Caparica

    Portugal

Accepting PhD Students

PhD projects

Structure-based Drug Design Structural Biology

  • 5453 Citations
  • 40 h-Index
1993 …2020

Research output per year

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Research Output at NOVA

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Article
2020

SLMP53-1 interacts with wild-type and mutant p53 DNA-binding domain and reactivates multiple hotspot mutations

Gomes, A. S., Ramos, H., Gomes, S., Loureiro, J. B., Soares, J., Barcherini, V., Monti, P., Fronza, G., Oliveira, C., Domingues, L., Bastos, M., Dourado, D. F. A. R., Carvalho, A. L., Romão, M. J., Pinheiro, B., Marcelo, F., Carvalho, A., Santos, M. M. M. & Saraiva, L., 1 Jan 2020, In : Biochimica et Biophysica Acta - General Subjects. 1864, 1, 129440.

Research output: Contribution to journalArticle

Open Access
3 Citations (Scopus)
2019

Human aldehyde oxidase (hAOX1): structure determination of the Moco-free form of the natural variant G1269R and biophysical studies of single nucleotide polymorphisms

Mota, C., Esmaeeli, M., Coelho, C., Santos-Silva, T., Wolff, M., Foti, A., Leimkühler, S. & Romão, M. J., 1 May 2019, In : FEBS Open Bio. 9, 5, p. 925-934 10 p.

Research output: Contribution to journalArticle

Open Access
File
3 Citations (Scopus)
3 Downloads (Pure)

New insights about the monomer and homodimer structures of the human AOX1

Ferreira, P., Cerqueira, N. M. F. S. A., Coelho, C., Fernandes, P. A., Romão, M. J. & Ramos, M. J., 1 Jan 2019, In : Physical Chemistry Chemical Physics. 21, 25, p. 13545-13554 10 p.

Research output: Contribution to journalArticle

File
1 Citation (Scopus)
1 Downloads (Pure)
Open Access
2018
Open Access
File
7 Citations (Scopus)
25 Downloads (Pure)

Irreversible Magnetic Behaviour Caused by the Thermosalient Phenomenon in an Iron(III) Spin Crossover Complex

Martins, F. F., Joseph, A., Diogo, H. P., Minas da Piedade, M. E., Ferreira, L. P., Carvalho, M. D., Barroso, S., Romão, M. J., Calhorda, M. J. & Martinho, P. N., 6 Jul 2018, In : European Journal of Inorganic Chemistry. 2018, 25, p. 2976-2983 8 p.

Research output: Contribution to journalArticle

Open Access
5 Citations (Scopus)

The crystal structure of the R280K mutant of human p53 explains the loss of DNA binding

Gomes, A. S., Trovão, F., Andrade Pinheiro, B., Freire, F., Gomes, S., Oliveira, C., Domingues, L., Romão, M. J., Saraiva, L. & Carvalho, A. L., 13 Apr 2018, In : International Journal of Molecular Sciences. 19, 4, 1184.

Research output: Contribution to journalArticle

Open Access
File
5 Citations (Scopus)
7 Downloads (Pure)
2017

A synthetic route to novel 3-substituted-2,1-benzisoxazoles from 5-(2-nitrobenzylidene)(thio)barbiturates

Serrano, J. L., Cavalheiro, E., Barroso, S., Romão, M. J., Silvestre, S. & Almeida, P., 1 Nov 2017, In : Comptes Rendus Chimie. 20, 11-12, p. 990-995 6 p.

Research output: Contribution to journalArticle

5 Citations (Scopus)

Electron transfer through arsenite oxidase: Insights into Rieske interaction with cytochrome c

Watson, C., Niks, D., Hille, R., Vieira, M., Schoepp-Cothenet, B., Marques, A. T., Romão, M. J., Santos-Silva, T. & Santini, J. M., 1 Oct 2017, In : Biochimica et Biophysica Acta - Bioenergetics. 1858, 10, p. 865-872 8 p.

Research output: Contribution to journalArticle

3 Citations (Scopus)
5 Citations (Scopus)

Ion-Exchange Membranes for Stable Derivatization of Protein Crystals

Polino, M., Carvalho, A. L., Juknaite, L., Portugal, C. A. M., Coelhoso, I. M., Romão, M. J. & Crespo, J. G., 6 Sep 2017, In : Crystal Growth and Design. 17, 9, p. 4563-4572 10 p.

Research output: Contribution to journalArticle

6 Citations (Scopus)

Stability and Ligand Promiscuity of Type A Carbohydrate-binding Modules Are Illustrated by the Structure of Spirochaeta thermophila StCBM64C

Pires, V. M. R., Pereira, P. M., Brás, J. L. A., Correia, M., Cardoso, V., Bule, P., Alves, V. D., Najmudin, S., Venditto, I., Ferreira, L. M. A., Romão, M. J., Carvalho, A. L., Fontes, C. M. G. A. & Prazeres, D. M., 24 Mar 2017, In : Journal of Biological Chemistry. 292, 12, p. 4847-4860 14 p.

Research output: Contribution to journalArticle

4 Citations (Scopus)
2016

Diverse specificity of cellulosome attachment to the bacterial cell surface

Brás, J. L. A., Pinheiro, B. A., Cameron, K., Cuskin, F., Viegas, A., Najmudin, S., Bule, P., Pires, V. M. R., Romão, M. J., Bayer, E. A., Spencer, H. L., Smith, S. P., Gilbert, H. J., Alves, V. D., Carvalho, A. L. & Fontes, C. M. G. A., 7 Dec 2016, In : Scientific Reports. 6, p. 38292

Research output: Contribution to journalArticle

Open Access
File
11 Citations (Scopus)
2 Downloads (Pure)

Optimization of the expression of human aldehyde oxidase for investigations of single-nucleotide polymorphisms

Foti, A., Hartmann, T., Coelho, C. M. C., Santos-Silva, T., Romão, M. J. & Leimkühler, S., 1 Aug 2016, In : Drug Metabolism And Disposition. 44, 8, p. 1277-1285 9 p.

Research output: Contribution to journalArticle

17 Citations (Scopus)

The Escherichia coli Periplasmic Aldehyde Oxidoreductase Is an Exceptional Member of the Xanthine Oxidase Family of Molybdoenzymes

Correia, M. A. S., Otrelo-Cardoso, A. R., Schwuchow, V., Sigfridsson Clauss, K. G. V., Haumann, M., Romão, M. J., Leimkühler, S. & Santos-Silva, T., 21 Oct 2016, In : ACS Chemical Biology. 11, 10, p. 2923-2935 13 p.

Research output: Contribution to journalArticle

10 Citations (Scopus)
2015

A contribution to the rational design of Ru(CO)3Cl2L complexes for in vivo delivery of CO

Seixas, J. D., Santos, M. F. A., Mukhopadhyay, A., Coelho, A. C., Reis, P. M., Veiros, L. F., Marques, A. R., Penacho, N., Gonçalves, A. M. L., Romão, M. J., Bernardes, G. J. L., Santos-Silva, T. S. & Romao, C. J., 21 Mar 2015, In : Dalton Transactions. 44, 11, p. 5058-5075 18 p.

Research output: Contribution to journalArticle

36 Citations (Scopus)
3 Citations (Scopus)

Insights into the structural determinants of substrate specificity and activity in mouse aldehyde oxidases

Cerqueira, N. M. F. S. A., Coelho, C. M. C., Brás, N. F., Fernandes, P. A., Garattini, E., Terao, M., Romão, M. J. & Ramos, M. J., 2015, In : Journal Of Biological Inorganic Chemistry. 20, 2, p. 209-217 9 p.

Research output: Contribution to journalArticle

17 Citations (Scopus)

Ionic-Liquid-Functionalized Mineral Particles for Protein Crystallization

Kowacz, M., Marchel, M., Juknaité, L., Esperança, J. M. S. S., Romão, M. J., Carvalho, A. L. & Rebelo, L. P. N., Jun 2015, In : Crystal Growth & Design. 15, 6, p. 2994-3003 10 p.

Research output: Contribution to journalArticle

5 Citations (Scopus)

Structural insights into xenobiotic and inhibitor binding to human aldehyde oxidase

Coelho, C. M. C., Foti, A., Hartmann, T., Santos-Silva, T. S., Leimkühler, S. & Romão, M. J., 2015, In : Nature Chemical Biology. 11, 10, p. 779-783 5 p.

Research output: Contribution to journalArticle

46 Citations (Scopus)
2014

Biochemical, Stabilization and Crystallization Studies on a Molecular Chaperone (PaoD) Involved in the Maturation of Molybdoenzymes

Otrelo-Cardoso, A. R., Schwuchow, V., Rodrigues, D., Cabrita, E. J., Leimkuehler, S., Romao, M. J. & Santos-Silva, T., 31 Jan 2014, In : PlosOne. 9, 1, 9 p., e87295.

Research output: Contribution to journalArticle

7 Citations (Scopus)

Structural Data on the Periplasmic Aldehyde Oxidoreductase PaoABC from Escherichia coli: SAXS and Preliminary X-ray Crystallography Analysis

Otrelo-Cardoso, A. R., da Silva Correia, M. A., Schwuchow, V., Svergun, D. I., Romão, M. J., Leimkuehler, S. & Santos-silva, T. S., Feb 2014, In : International Journal of Molecular Sciences. 15, 2, p. 2223-2236

Research output: Contribution to journalArticle

Open Access
6 Citations (Scopus)

Use of gold nanoparticles as additives in protein crystallization

Ribeiro, D., Kulakova, A., Quaresma, P., Pereira, E., Bonifácio, C., Romão, M. J., Franco, R. & Carvalho, A. L., 2 Jan 2014, In : Crystal Growth & Design. 14, 1, p. 222-227 6 p.

Research output: Contribution to journalArticle

14 Citations (Scopus)
2013

Characterization of a versatile organometallic pro-drug (CORM) for experimental CO based therapeutics

Seixas, J. D., Mukhopadhyay, A., Santos-silva, T. S., Otterbein, L. E., Gallo, D. J., Rodrigues, S. S., Guerreiro, B., Gonçalves, A. M. L., Penacho, N., Marques, A. R., Coelho, A. C., Reis, P. M., Romão, M. J. & Romao, C. C., 7 May 2013, In : Dalton Transactions. 42, 17, p. 5985-5998

Research output: Contribution to journalArticle

39 Citations (Scopus)

Identification of Crucial Amino Acids in Mouse Aldehyde Oxidase 3 That Determine Substrate Specificity

Romão, M. J., 1 Jan 2013, In : PLoS ONE. 8, 12, p. e82285

Research output: Contribution to journalArticle

Open Access
16 Citations (Scopus)
8 Citations (Scopus)

Interaction of vanadium (IV) with human serum apo-transferrin.

Santos-silva, T. S. & Romão, M. J., 1 Jan 2013, In : Journal of Inorganic Biochemistry. 121, NA, p. 187-95

Research output: Contribution to journalArticle

Open Access
50 Citations (Scopus)
Open Access
File
3 Citations (Scopus)
1 Downloads (Pure)
13 Citations (Scopus)
2012

Escherichia coli expression, purification, crystallization, and structure determination of bacterial cohesin-dockerin complexes

Brás, J. L. A., Carvalho, A. L., Viegas, A., Najmudin, S., Alves, V. D., Prates, J. A. M., Ferreira, L. M. A., Romão, M. J., Gilbert, H. J. & Fontes, C. M. G. A., 22 May 2012, In : Methods in Enzymology. 510, p. 395-415 21 p.

Research output: Contribution to journalArticle

4 Citations (Scopus)
Open Access
27 Citations (Scopus)

Novel Clostridium thermocellum type I cohesin-dockerin complexes reveal a single binding mode

Brás, J. L. A., Alves, V. D., Carvalho, A. L., Najmudin, S., Prates, J. A. M., Ferreira, L. M. A., Bolam, D. N., Romão, M. J., Gilbert, H. J. & Fontes, C. M. G. A., 28 Dec 2012, In : Journal of Biological Chemistry. 287, 53, p. 44394-44405 12 p.

Research output: Contribution to journalArticle

Open Access
File
21 Citations (Scopus)

The first mammalian aldehyde oxidase crystal structure: Insights into substrate specificity

Coelho, C., Mahro, M., Trincão, J., Carvalho, A. T. P., Ramos, M. J., Terao, M., Garattini, E., Leimkühler, S. & Romão, M. J., 23 Nov 2012, In : Journal of Biological Chemistry. 287, 48, p. 40690-40702 13 p.

Research output: Contribution to journalArticle

Open Access
File
68 Citations (Scopus)
5 Downloads (Pure)

CORM-3 Reactivity toward Proteins: The Crystal Structure of a Ru(II) Dicarbonyl-Lysozyme Complex

Santos-silva, T. S., Mukhopadhyay, A., Seixas, J. D., Bernardes, G. J. L., Romao, C. J. & Romão, M. J., 4 Jan 2011, In : Journal of the American Chemical Society. 133, 5, p. 1192-1195

Research output: Contribution to journalArticle

Open Access
125 Citations (Scopus)
Open Access
24 Citations (Scopus)
Open Access
42 Citations (Scopus)

Putting an N-terminal end to the Clostridium thermocellum xylanase Xyn10B story: crystal structure of the CBM22-1-GH10 modules complexed with xylohexaose

Najmudin, S., Pinheiro, B. A., Prates, J. A. M., Gilbert, H. J., Romão, M. J. & Fontes, C. M. G. A., Dec 2010, In : Journal Of Structural Biology. 172, 3, p. 353-362 10 p.

Research output: Contribution to journalArticle

39 Citations (Scopus)
Open Access
File
15 Citations (Scopus)
4 Downloads (Pure)