• FCT-NOVA, Campus Caparica, Unidade de Ciências Biomoleculares Aplicadas (UCIBIO)

    2829-516 Caparica

  • FCT-NOVA, Faculdade de Ciências e Tecnologia, Campus Caparica, Departamento de Química

    2829-516 Caparica

    Portugal

Accepting PhD Students

  • 5391 Citations
  • 40 h-Index
1993 …2020

Research output per year

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Research Output at NOVA

2020

SLMP53-1 interacts with wild-type and mutant p53 DNA-binding domain and reactivates multiple hotspot mutations

Gomes, A. S., Ramos, H., Gomes, S., Loureiro, J. B., Soares, J., Barcherini, V., Monti, P., Fronza, G., Oliveira, C., Domingues, L., Bastos, M., Dourado, D. F. A. R., Carvalho, A. L., Romão, M. J., Pinheiro, B., Marcelo, F., Carvalho, A., Santos, M. M. M. & Saraiva, L., 1 Jan 2020, In : Biochimica et Biophysica Acta - General Subjects. 1864, 1, 129440.

Research output: Contribution to journalArticle

Open Access
3 Citations (Scopus)
2019

Aldehyde Oxidases as Enzymes in Phase I Drug Metabolism

Mota, C., Santos-Silva, T. S., Terao, M., Garattini, E., Romão, M. J. & Leimkühler, S., 27 Jun 2019, Pharmaceutical Biocatalysis: Fundamentals, Enzyme Inhibitors, and Enzymes in Health and Diseases. Grunwald, P. (ed.). Routledge Taylor & Francis Group, 27 p.

Research output: Chapter in Book/Report/Conference proceedingChapter

Human aldehyde oxidase (hAOX1): structure determination of the Moco-free form of the natural variant G1269R and biophysical studies of single nucleotide polymorphisms

Mota, C., Esmaeeli, M., Coelho, C., Santos-Silva, T., Wolff, M., Foti, A., Leimkühler, S. & Romão, M. J., 1 May 2019, In : FEBS Open Bio. 9, 5, p. 925-934 10 p.

Research output: Contribution to journalArticle

Open Access
File
3 Citations (Scopus)
2 Downloads (Pure)

New insights about the monomer and homodimer structures of the human AOX1

Ferreira, P., Cerqueira, N. M. F. S. A., Coelho, C., Fernandes, P. A., Romão, M. J. & Ramos, M. J., 1 Jan 2019, In : Physical Chemistry Chemical Physics. 21, 25, p. 13545-13554 10 p.

Research output: Contribution to journalArticle

File
1 Citation (Scopus)
2018

Critical overview on the structure and metabolism of human aldehyde oxidase and its role in pharmacokinetics

Mota, C., Coelho, C., Leimkühler, S., Garattini, E., Terao, M., Santos-Silva, T. & Romão, M. J., 1 Aug 2018, In : Coordination Chemistry Reviews. 368, p. 35-59 25 p.

Research output: Contribution to journalReview article

7 Citations (Scopus)
Open Access
File
7 Citations (Scopus)
25 Downloads (Pure)

Irreversible Magnetic Behaviour Caused by the Thermosalient Phenomenon in an Iron(III) Spin Crossover Complex

Martins, F. F., Joseph, A., Diogo, H. P., Minas da Piedade, M. E., Ferreira, L. P., Carvalho, M. D., Barroso, S., Romão, M. J., Calhorda, M. J. & Martinho, P. N., 6 Jul 2018, In : European Journal of Inorganic Chemistry. 2018, 25, p. 2976-2983 8 p.

Research output: Contribution to journalArticle

Open Access
3 Citations (Scopus)

Structural elucidation of macromolecules

Romão, M. J., Santos-Silva, T. S., Carvalho, A. L., Cabrita, E. J. & Marcelo, F. M. B. M., 2018, Essential Techniques for Medical and Life Scientists : A Guide to Contemporary Methods and Current Applications With the Protocols. Bentham Science Publishers Ltd., Vol. Pt.1. p. 30-91 61 p.

Research output: Chapter in Book/Report/Conference proceedingChapter

The crystal structure of human aldehyde oxidase

Romao, M. J., Jan 2018, In : DRUG METABOLISM AND PHARMACOKINETICS. 33, 1, p. S10-S11

Research output: Contribution to journalMeeting Abstract

The crystal structure of the R280K mutant of human p53 explains the loss of DNA binding

Gomes, A. S., Trovão, F., Andrade Pinheiro, B., Freire, F., Gomes, S., Oliveira, C., Domingues, L., Romão, M. J., Saraiva, L. & Carvalho, A. L., 13 Apr 2018, In : International Journal of Molecular Sciences. 19, 4, 1184.

Research output: Contribution to journalArticle

Open Access
File
5 Citations (Scopus)
7 Downloads (Pure)
2017

A synthetic route to novel 3-substituted-2,1-benzisoxazoles from 5-(2-nitrobenzylidene)(thio)barbiturates

Serrano, J. L., Cavalheiro, E., Barroso, S., Romão, M. J., Silvestre, S. & Almeida, P., 1 Nov 2017, In : Comptes Rendus Chimie. 20, 11-12, p. 990-995 6 p.

Research output: Contribution to journalArticle

5 Citations (Scopus)

Electron transfer through arsenite oxidase: Insights into Rieske interaction with cytochrome c

Watson, C., Niks, D., Hille, R., Vieira, M., Schoepp-Cothenet, B., Marques, A. T., Romão, M. J., Santos-Silva, T. & Santini, J. M., 1 Oct 2017, In : Biochimica et Biophysica Acta - Bioenergetics. 1858, 10, p. 865-872 8 p.

Research output: Contribution to journalArticle

3 Citations (Scopus)
4 Citations (Scopus)

Ion-Exchange Membranes for Stable Derivatization of Protein Crystals

Polino, M., Carvalho, A. L., Juknaite, L., Portugal, C. A. M., Coelhoso, I. M., Romão, M. J. & Crespo, J. G., 6 Sep 2017, In : Crystal Growth and Design. 17, 9, p. 4563-4572 10 p.

Research output: Contribution to journalArticle

5 Citations (Scopus)

Stability and Ligand Promiscuity of Type A Carbohydrate-binding Modules Are Illustrated by the Structure of Spirochaeta thermophila StCBM64C

Pires, V. M. R., Pereira, P. M., Brás, J. L. A., Correia, M., Cardoso, V., Bule, P., Alves, V. D., Najmudin, S., Venditto, I., Ferreira, L. M. A., Romão, M. J., Carvalho, A. L., Fontes, C. M. G. A. & Prazeres, D. M., 24 Mar 2017, In : Journal of Biological Chemistry. 292, 12, p. 4847-4860 14 p.

Research output: Contribution to journalArticle

3 Citations (Scopus)

Structural basis for the role of mammalian aldehyde oxidases in the metabolism of drugs and xenobiotics

Romão, M. J., Coelho, C., Santos-Silva, T., Foti, A., Terao, M., Garattini, E. & Leimkühler, S., 1 Apr 2017, In : Current Opinion in Chemical Biology. 37, p. 39-47 9 p.

Research output: Contribution to journalReview article

11 Citations (Scopus)
2016

An integrative strategy to decipher glycan recognition in the human gut microbiome

Correia, V. G., Bras, J. L. A., Liu, Y., Silva, L., Zhang, Y., Pinheiro, B. A., Romao, M. J., Carvalho, A. L., Chai, W., Fontes, C. M. G. A., Feizi, T. & Palma, A. S., Dec 2016, In : Glycobiology. 26, 12, p. 1398-1399 2 p.

Research output: Contribution to journalMeeting Abstract

Diverse specificity of cellulosome attachment to the bacterial cell surface

Brás, J. L. A., Pinheiro, B. A., Cameron, K., Cuskin, F., Viegas, A., Najmudin, S., Bule, P., Pires, V. M. R., Romão, M. J., Bayer, E. A., Spencer, H. L., Smith, S. P., Gilbert, H. J., Alves, V. D., Carvalho, A. L. & Fontes, C. M. G. A., 7 Dec 2016, In : Scientific Reports. 6, p. 38292

Research output: Contribution to journalArticle

Open Access
File
11 Citations (Scopus)
2 Downloads (Pure)

Optimization of the expression of human aldehyde oxidase for investigations of single-nucleotide polymorphisms

Foti, A., Hartmann, T., Coelho, C. M. C., Santos-Silva, T., Romão, M. J. & Leimkühler, S., 1 Aug 2016, In : Drug Metabolism And Disposition. 44, 8, p. 1277-1285 9 p.

Research output: Contribution to journalArticle

15 Citations (Scopus)

Structure and function of mammalian aldehyde oxidases

Terao, M., Romao, M. J., Leimkuehler, S., Bolis, M., Fratelli, M., Coelho, C. M. C., Santos-Silva, T. S. & Garattini, E., Apr 2016, In : Archives Of Toxicology. 90, 4, p. 753-780 28 p.

Research output: Contribution to journalLiterature review

Open Access
39 Citations (Scopus)

The Escherichia coli Periplasmic Aldehyde Oxidoreductase Is an Exceptional Member of the Xanthine Oxidase Family of Molybdoenzymes

Correia, M. A. S., Otrelo-Cardoso, A. R., Schwuchow, V., Sigfridsson Clauss, K. G. V., Haumann, M., Romão, M. J., Leimkühler, S. & Santos-Silva, T., 21 Oct 2016, In : ACS Chemical Biology. 11, 10, p. 2923-2935 13 p.

Research output: Contribution to journalArticle

8 Citations (Scopus)
2015

A contribution to the rational design of Ru(CO)3Cl2L complexes for in vivo delivery of CO

Seixas, J. D., Santos, M. F. A., Mukhopadhyay, A., Coelho, A. C., Reis, P. M., Veiros, L. F., Marques, A. R., Penacho, N., Gonçalves, A. M. L., Romão, M. J., Bernardes, G. J. L., Santos-Silva, T. S. & Romao, C. J., 21 Mar 2015, In : Dalton Transactions. 44, 11, p. 5058-5075 18 p.

Research output: Contribution to journalArticle

34 Citations (Scopus)
2 Citations (Scopus)

Insights into the structural determinants of substrate specificity and activity in mouse aldehyde oxidases

Cerqueira, N. M. F. S. A., Coelho, C. M. C., Brás, N. F., Fernandes, P. A., Garattini, E., Terao, M., Romão, M. J. & Ramos, M. J., 2015, In : Journal Of Biological Inorganic Chemistry. 20, 2, p. 209-217 9 p.

Research output: Contribution to journalArticle

16 Citations (Scopus)

Ionic-Liquid-Functionalized Mineral Particles for Protein Crystallization

Kowacz, M., Marchel, M., Juknaité, L., Esperança, J. M. S. S., Romão, M. J., Carvalho, A. L. & Rebelo, L. P. N., Jun 2015, In : Crystal Growth & Design. 15, 6, p. 2994-3003 10 p.

Research output: Contribution to journalArticle

5 Citations (Scopus)

Structural and mechanistic insights on nitrate reductases

Coelho, C. M. C. & Romão, M. J., 1 Dec 2015, In : Protein Science. 24, 12, p. 1901-1911 11 p.

Research output: Contribution to journalReview article

16 Citations (Scopus)

Structural insights into xenobiotic and inhibitor binding to human aldehyde oxidase

Coelho, C. M. C., Foti, A., Hartmann, T., Santos-Silva, T. S., Leimkühler, S. & Romão, M. J., 2015, In : Nature Chemical Biology. 11, 10, p. 779-783 5 p.

Research output: Contribution to journalArticle

45 Citations (Scopus)
2014

Biochemical, Stabilization and Crystallization Studies on a Molecular Chaperone (PaoD) Involved in the Maturation of Molybdoenzymes

Otrelo-Cardoso, A. R., Schwuchow, V., Rodrigues, D., Cabrita, E. J., Leimkuehler, S., Romao, M. J. & Santos-Silva, T., 31 Jan 2014, In : PlosOne. 9, 1, 9 p., e87295.

Research output: Contribution to journalArticle

6 Citations (Scopus)

Erratum: Use of gold nanoparticles as additives in protein crystallization (Crystal Growth and Design (2014) 14:1 (222-227) DOI:10.1021/cg4014398)

Ribeiro, D., Kulakova, A., Quaresma, P., Pereira, E., Bonifácio, C., Romão, M. J., Franco, R. & Carvalho, A. L., 5 Feb 2014, In : Crystal Growth & Design. 14, 2, p. 888 1 p.

Research output: Contribution to journalComment/debate

Open Access

Structural Data on the Periplasmic Aldehyde Oxidoreductase PaoABC from Escherichia coli: SAXS and Preliminary X-ray Crystallography Analysis

Otrelo-Cardoso, A. R., da Silva Correia, M. A., Schwuchow, V., Svergun, D. I., Romão, M. J., Leimkuehler, S. & Santos-silva, T. S., Feb 2014, In : International Journal of Molecular Sciences. 15, 2, p. 2223-2236

Research output: Contribution to journalArticle

Open Access
6 Citations (Scopus)

Use of gold nanoparticles as additives in protein crystallization

Ribeiro, D., Kulakova, A., Quaresma, P., Pereira, E., Bonifácio, C., Romão, M. J., Franco, R. & Carvalho, A. L., 2 Jan 2014, In : Crystal Growth & Design. 14, 1, p. 222-227 6 p.

Research output: Contribution to journalArticle

13 Citations (Scopus)
2013

Characterization of a versatile organometallic pro-drug (CORM) for experimental CO based therapeutics

Seixas, J. D., Mukhopadhyay, A., Santos-silva, T. S., Otterbein, L. E., Gallo, D. J., Rodrigues, S. S., Guerreiro, B., Gonçalves, A. M. L., Penacho, N., Marques, A. R., Coelho, A. C., Reis, P. M., Romão, M. J. & Romao, C. C., 7 May 2013, In : Dalton Transactions. 42, 17, p. 5985-5998

Research output: Contribution to journalArticle

39 Citations (Scopus)

Determinants of selective group reduction in the TNT-bound xenobiotic reductase B from P. putida

Carvalho, A. L. M. D. & Romão, M. J., 1 Jan 2013, 233 SPRING ST, NEW YORK, NY 10013 USA : Springer.

Research output: Other contribution

Identification of Crucial Amino Acids in Mouse Aldehyde Oxidase 3 That Determine Substrate Specificity

Romão, M. J., 1 Jan 2013, In : PLoS ONE. 8, 12, p. e82285

Research output: Contribution to journalArticle

Open Access
16 Citations (Scopus)
8 Citations (Scopus)

Interaction of vanadium (IV) with human serum apo-transferrin.

Santos-silva, T. S. & Romão, M. J., 1 Jan 2013, In : Journal of Inorganic Biochemistry. 121, NA, p. 187-95

Research output: Contribution to journalArticle

Open Access
50 Citations (Scopus)
Open Access
File
3 Citations (Scopus)
13 Citations (Scopus)

Unraveling new functions and modes of action of molybdenum-dependent enzymes

Romão, M. J., 1 Jan 2013, 233 SPRING ST, NEW YORK, NY 10013 USA : Springer.

Research output: Other contribution

Vanadium compounds as prospective therapeutics: X-ray structure of protein adducts

Santos-silva, T. S. & Romão, M. J., 1 Jan 2013, 233 SPRING ST, NEW YORK, NY 10013 USA : Springer.

Research output: Other contribution

2012

Escherichia coli expression, purification, crystallization, and structure determination of bacterial cohesin-dockerin complexes

Brás, J. L. A., Carvalho, A. L., Viegas, A., Najmudin, S., Alves, V. D., Prates, J. A. M., Ferreira, L. M. A., Romão, M. J., Gilbert, H. J. & Fontes, C. M. G. A., 22 May 2012, In : Methods in Enzymology. 510, p. 395-415 21 p.

Research output: Contribution to journalArticle

4 Citations (Scopus)
Open Access
27 Citations (Scopus)

Novel Clostridium thermocellum type I cohesin-dockerin complexes reveal a single binding mode

Brás, J. L. A., Alves, V. D., Carvalho, A. L., Najmudin, S., Prates, J. A. M., Ferreira, L. M. A., Bolam, D. N., Romão, M. J., Gilbert, H. J. & Fontes, C. M. G. A., 28 Dec 2012, In : Journal of Biological Chemistry. 287, 53, p. 44394-44405 12 p.

Research output: Contribution to journalArticle

Open Access
File
20 Citations (Scopus)