Maria João Aleixo da Silva

2024

Challenges of the Application of In Vitro Digestion for Nanomaterials Safety Assessment

Vital, N., Gramacho, A. C., Silva, M., Cardoso, M., Alvito, P., Kranendonk, M., Silva, M. J. & Louro, H., Jun 2024, In: Foods. 13, 11, 1690.

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1 Citation (Scopus)

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HBM4EU e-waste study: Occupational exposure of electronic waste workers to phthalates and DINCH in Europe

Cleys, P., Hardy, E., Bamai, YA., Poma, G., Cseresznye, A., Malarvannan, G., Scheepers, PTJ., Viegas, S., Porras, SP., Santonen, T., Godderis, L., Verdonck, J., Poels, K., Martins, C., Silva, MJ., Louro, H., Martinsone, I., Akülova, L., van Nieuwenhuyse, A., Graumans, M., & 3 othersMahiout, S., Duca, RC. & Covaci, A., Jan 2024, In: International Journal Of Hygiene And Environmental Health. 255, 114286.

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1 Citation (Scopus)

2023

Assessing the Genotoxicity of Cellulose Nanomaterials in a Co-Culture of Human Lung Epithelial Cells and Monocyte-Derived Macrophages

Ventura, C., Pinto, F., Lourenço, A. F., Pedrosa, J. F. S., Fernandes, S. N., da Rosa, R. R., Godinho, M. H., Ferreira, P. J. T., Louro, H. & Silva, M. J., Aug 2023, In: Bioengineering. 10, 8, 986.

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How to use human biomonitoring in chemical risk assessment: Methodological aspects, recommendations, and lessons learned from HBM4EU

Santonen, T., Mahiout, S., Alvito, P., Apel, P., Bessems, J., Bil, W., Borges, T., Bose-O'Reilly, S., Buekers, J., Cañas Portilla, A. I., Calvo, A. C., de Alba González, M., Domínguez-Morueco, N., López, M. E., Falnoga, I., Gerofke, A., Caballero, M. D. C. G., Horvat, M., Huuskonen, P., Kadikis, N., & 22 othersKolossa-Gehring, M., Lange, R., Louro, H., Martins, C., Meslin, M., Niemann, L., Díaz, S. P., Plichta, V., Porras, S. P., Rousselle, C., Scholten, B., Silva, M. J., Šlejkovec, Z., Tratnik, J. S., Joksić, A. Š., Tarazona, J. V., Uhl, M., Van Nieuwenhuyse, A., Viegas, S., Vinggaard, A. M., Woutersen, M. & Schoeters, G., Apr 2023, In: International Journal Of Hygiene And Environmental Health. 249, 114139.

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8 Citations (Scopus)

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Interpreting biomonitoring data: Introducing the international human biomonitoring (i-HBM) working group's health-based guidance value (HB2GV) dashboard

Nakayama, S. F., St-Amand, A., Pollock, T., Apel, P., Bamai, Y. A., Barr, D. B., Bessems, J., Calafat, A. M., Castaño, A., Covaci, A., Duca, R. C., Faure, S., Galea, K. S., Hays, S., Hopf, N. B., Ito, Y., Jeddi, M. Z., Kolossa-Gehring, M., Kumar, E., LaKind, J. S., & 18 othersLópez, M. E., Louro, H., Macey, K., Makris, K. C., Melnyk, L., Murawski, A., Naiman, J., Nassif, J., Noisel, N., Poddalgoda, D., Quirós-Alcalá, L., Rafiee, A., Rambaud, L., Silva, M. J., Ueyama, J., Verner, M. A., Waras, M. N. & Werry, K., Jan 2023, In: International Journal Of Hygiene And Environmental Health. 247, 114046.

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17 Citations (Scopus)

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2022

Analysis of the In Vitro Toxicity of Nanocelluloses in Human Lung Cells as Compared to Multi-Walled Carbon Nanotubes

Pinto, F., Lourenço, A. F., Pedrosa, J. F. S., Gonçalves, L., Ventura, C., Vital, N., Bettencourt, A., Fernandes, S. N., da Rosa, R. R., Godinho, M. H., Louro, H., Ferreira, P. J. T. & Silva, M. J., 22 Apr 2022, In: Nanomaterials. 12, 9, 1432.

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16 Citations (Scopus)

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Aplicação da biomonitorização humana para avaliação da exposição ocupacional a hidrocarbonetos aromáticos policíclicos na Europa: uma revisão da literatura

Translated title of the contribution: Application of human biomonitoring to assess occupational exposure to polycyclic aromatic hydrocarbons in Europe: a literature reviewLouro, H., Costa Gomes, B., Saber, A. T., Iamiceli, A. L., Göen, T., Jones, K., Katsonouri, A., Neophytou, C. M., Vogel, U., Ventura, C., Oberemm, A., Duca, R. C., Fernandez, M. F., Olea, N., Santonen, T., Viegas, S. & Silva, M. J. A. D., 2022, In: Observações_Boletim Epidemiológico. 9, nº esp. 14, p. 54-59

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Caracterização de biomarcadores de genotoxicidade em trabalhadores expostos a crómio hexavalente: um estudo no âmbito da Iniciativa Europeia em Biomonitorização Humana

Translated title of the contribution: Genotoxicity biomarkers in workers exposed to hexavalent chromium: a study under the European Human Biomonitoring InitiativeTavares, A., Aimonen, K., Ndaw, S., Fucic, A., Catalán, J., Duca, R. C., Godderis, L., Costa Gomes, B., Janasik, B., Ladeira, C., Louro, H., Vieira, S. C. N. G. C., van Nieuwenhuyse, A., Norppa, H., Scheepers, P. T. J., Ventura, C., Verdonck, J., Viegas, S., Wasowicz, W., Santonen, T., & 1 othersSilva, M. J. A. D., 2022, In: Observações_Boletim Epidemiológico. 9, nº esp. 14, p. 40-46

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Genotoxicity of Three Micro/Nanocelluloses with Different Physicochemical Characteristics in MG-63 and V79 Cells

Ventura, C., Marques, C., Cadete, J., Vilar, M., Pedrosa, J. F. S., Pinto, F., Fernandes, S. N., Rosa, R. R. D., Godinho, M. H., Ferreira, P. J. T., Louro, H. & Silva, M. J., 21 Apr 2022, In: Journal of Xenobiotics. 12, 2, p. 91-108 18 p.

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6 Citations (Scopus)

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HBM4EU chromates study: determinants of exposure to hexavalent chromium in plating, welding and other occupational settings

Viegas, S., Martins, C., Bocca, B., Bousoumah, R., Duca, R. C., Galea, K. S., Godderis, L., Iavicoli, I., Janasik, B., Jones, K., Leese, E., Leso, V., Ndaw, S., van Nieuwenhuyse, A., Poels, K., Porras, S. P., Ruggieri, F., Silva, M. J., Verdonck, J., Wasowicz, W., & 2 othersScheepers, P. T. J. & Santonen, T., 1 Mar 2022, In: International Journal of Environmental Research and Public Health. 19, 6, 3683.

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15 Citations (Scopus)

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HBM4EU chromates study: usefulness of measurement of blood chromium levels in the assessment of occupational Cr(VI) exposure

Ndaw, S., Leso, V., Bousoumah, R., Rémy, A., Bocca, B., Duca, R. C., Godderis, L., Hardy, E., Janasik, B., van Nieuwenhuyse, A., Pinhal, H., Poels, K., Porras, S. P., Ruggieri, F., Santonen, T., Santos, S. R., Scheepers, P. T. J., Silva, M. J., Verdonck, J., Viegas, S., & 2 othersWasowicz, W. & Iavicoli, I., Nov 2022, In: Environmental Research. 214, Pt 1, 113758.

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13 Citations (Scopus)

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HBM4EU Chromates Study: urinary metabolomics study of workers exposed to hexavalent chromium

Kozłowska, L., Santonen, T., Duca, R. C., Godderis, L., Jagiello, K., Janasik, B., Van Nieuwenhuyse, A., Poels, K., Puzyn, T., Scheepers, P. T. J., Sijko, M., Silva, M. J., Sosnowska, A., Viegas, S., Verdonck, J., Wąsowicz, W., On Behalf Of Hbm Eu Chromates Study Team & On Behalf Of Statistical Team, 18 Apr 2022, In: Metabolites. 12, 4, 362.

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7 Citations (Scopus)

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HBM4EU Chromates Study-Genotoxicity and Oxidative Stress Biomarkers in Workers Exposed to Hexavalent Chromium

Tavares, A., Aimonen, K., Ndaw, S., Fučić, A., Catalán, J., Duca, R. C., Godderis, L., Gomes, B. C., Janasik, B., Ladeira, C., Louro, H., Namorado, S., Nieuwenhuyse, A. V., Norppa, H., Scheepers, P. T. J., Ventura, C., Verdonck, J., Viegas, S., Wasowicz, W., Santonen, T., & 1 othersSilva, M. J., 18 Aug 2022, In: Toxics. 10, 8, 483.

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8 Citations (Scopus)

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HBM4EU Diisocyanates Study-Research Protocol for a Collaborative European Human Biological Monitoring Study on Occupational Exposure

Jones, K., Galea, K. S., Scholten, B., Loikala, M., Porras, S. P., Bousoumah, R., Ndaw, S., Leese, E., Louro, H., Silva, M. J., Viegas, S., Godderis, L., Verdonck, J., Poels, K., Gӧen, T., Duca, R-C., Santonen, T. & Hbm Eu Diisocyanates Study Team, 20 Jul 2022, In: International Journal of Environmental Research and Public Health. 19, 14, 8811.

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8 Citations (Scopus)

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Investigation of the genotoxicity of digested titanium dioxide nanomaterials in human intestinal cells

Vieira, A., Vital, N., Rolo, D., Roque, R., Gonçalves, L. M., Bettencourt, A., Silva, M. J. & Louro, H., Mar 2022, In: Food and Chemical Toxicology. 161, 112841.

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7 Citations (Scopus)

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Occupational exposure to hexavalent chromium, nickel and PAHs: a mixtures risk assessment approach based on literature exposure data from european countries

Tavares, A. M., Viegas, S., Louro, H., Göen, T., Santonen, T., Luijten, M., Kortenkamp, A. & Silva, M. J., 29 Jul 2022, In: Toxics. 10, 8, 431.

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6 Citations (Scopus)

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Perceções da população portuguesa sobre biomonitorização humana segundo o inquérito aos cidadãos do HBM4EU: Portuguese population’s perceptions on Human Biomonitoring according to the HBM4EU citizen survey

Vieira, S. C. N. G. C., Louro, H., Isidro, G., Cavaleiro, R., Moura, I., Borges, T., Virgolino, A., Santos, O., Lobo Vicente, J. & Silva, M. J. A. D., 2022, In: Observações_Boletim Epidemiológico. 9, nº esp. 14, p. 5-10

Research output: Contribution to journal › Article

2021

Environmental Tobacco Smoke in Occupational Settings: Effect and Susceptibility Biomarkers in Workers From Lisbon Restaurants and Bars

Vital, N., Antunes, S., Louro, H., Vaz, F., Simões, T., Penque, D. & Silva, M. J., 4 Jun 2021, In: Frontiers in public health. 9, 674142.

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4 Citations (Scopus)

92 Downloads (Pure)

HBM4EU chromates study: reflection and lessons learnt from designing and undertaking a collaborative European biomonitoring study on occupational exposure to hexavalent chromium

Galea, K. S., Porras, S. P., Viegas, S., Bocca, B., Bousoumah, R., Duca, R. C., Godderis, L., Iavicoli, I., Janasik, B., Jones, K., Knudsen, L. E., Leese, E., Leso, V., Louro, H., Ndaw, S., Ruggieri, F., Sepai, O., Scheepers, P. T. J., Silva, M. J., Wasowicz, W., & 1 othersSantonen, T., May 2021, In: International Journal Of Hygiene And Environmental Health. 234, 113725.

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18 Citations (Scopus)

224 Downloads (Pure)

HBM4EU occupational biomonitoring study on e-waste: study protocol

Scheepers, P. T. J., Duca, R. C., Galea, K. S., Godderis, L., Hardy, E., Knudsen, L. E., Leese, E., Louro, H., Mahiout, S., Ndaw, S., Poels, K., Porras, S. P., Silva, M. J., Tavares, A. M., Verdonck, J., Viegas, S., Santonen, T. & Martins, C., 2021, In: International Journal of Environmental Research and Public Health. 18, 24, 12987.

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14 Citations (Scopus)

29 Downloads (Pure)

2020

Analysis of the characteristics and cytotoxicity of titanium dioxide nanomaterials following simulated in vitro digestion

Bettencourt, A., Gonçalves, L. M., Gramacho, A. C., Vieira, A., Rolo, D., Martins, C., Assunção, R., Alvito, P., Silva, M. J. & Louro, H., Aug 2020, In: Nanomaterials. 10, 8, 18 p., 1516.

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23 Citations (Scopus)

107 Downloads (Pure)

Combined cytotoxic and genotoxic effects of ochratoxin A and fumonisin B₁ in human kidney and liver cell models

Pinhão, M., Tavares, A. M., Loureiro, S., Louro, H., Alvito, P. & Silva, M. J., Oct 2020, In: Toxicology In Vitro. 68, 104949.

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25 Citations (Scopus)

Cytotoxicity and genotoxicity of MWCNT-7 and crocidolite: assessment in alveolar epithelial cells versus their coculture with monocyte-derived macrophages

Ventura, C., Pereira, J. F. S., Matos, P., Marques, B., Jordan, P., Sousa-Uva, A. & Silva, M. J., 20 Apr 2020, In: Nanotoxicology. 14, 4, p. 479-503

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25 Citations (Scopus)

Functional effects of differentially expressed microRNAs in A549 cells exposed to MWCNT-7 or crocidolite

Ventura, C., Vieira, L., Silva, C., Sousa-Uva, A. & Silva, M. J., 17 Apr 2020, (E-pub ahead of print) In: Toxicology Letters. 328, p. 7-18

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4 Citations (Scopus)

2019

A multi-endpoint approach to the combined toxic effects of patulin and ochratoxin a in human intestinal cells

Assunção, R., Pinhão, M., Loureiro, S., Alvito, P. & Silva, M. J., 1 Oct 2019, In: Toxicology Letters. 313, p. 120-129 10 p.

Research output: Contribution to journal › Article › peer-review

30 Citations (Scopus)

Biological impact of metal nanomaterials in relation to their physicochemical characteristics

Louro, H., Saruga, A., Santos, J., Pinhão, M. & Silva, M. J., 1 Apr 2019, In: Toxicology In Vitro. 56, p. 172-183 12 p.

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13 Citations (Scopus)

In vitro exposure to the next-generation plasticizer diisononyl cyclohexane-1,2-dicarboxylate (DINCH): cytotoxicity and genotoxicity assessment in human cells

Vasconcelos, A. L., Silva, M. J. & Louro, H., 3 May 2019, In: Journal of Toxicology and Environmental Health - Part A: Current Issues. 82, 9, p. 526-536

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22 Citations (Scopus)

Setting up a collaborative European human biological monitoring study on occupational exposure to hexavalent chromium

Santonen, T., Alimonti, A., Bocca, B., Duca, R. C., Galea, K. S., Godderis, L., Göen, T., Gomes, B., Hanser, O., Iavicoli, I., Janasik, B., Jones, K., Kiilunen, M., Koch, H. M., Leese, E., Leso, V., Louro, H., Ndaw, S., Porras, S. P., Robert, A., & 7 othersRuggieri, F., Scheepers, P. T. J., Silva, M. J., Viegas, S., Wasowicz, W., Castano, A. & Sepai, O., 1 Oct 2019, In: Environmental Research. 108583.

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55 Citations (Scopus)

2018

Evaluating the genotoxicity of cellulose nanofibrils in a co-culture of human lung epithelial cells and monocyte-derived macrophages

Ventura, C., Lourenço, A. F., Sousa-Uva, A., Ferreira, P. J. T. & Silva, M. J., 1 Jul 2018, In: Toxicology Letters. 291, p. 173-183 11 p.

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39 Citations (Scopus)

Using Eco-Sensors to Support Children's Participation in Environmental Health

Silva, M. J., Ferreira, E., Souza, A., Alves, A. R. & Batista, S., 2018, In: International Journal of Digital Literacy and Digital Competence. 9, 4, p. 33-45 12 p.

Research output: Contribution to journal › Article › peer-review

Open Access

2017

Environmental risk assessment in a contaminated estuary: An integrated weight of evidence approach as a decision support tool

Caeiro, S., Vaz-Fernandes, P., Martinho, A. P., Costa, P. M., Silva, M. J., Lavinha, J., Matias-Dias, C., Machado, A., Castanheira, I. & Costa, M. H., 1 Jul 2017, In: Ocean & Coastal Management. 143, p. 51-62 12 p.

Research output: Contribution to journal › Article › peer-review

11 Citations (Scopus)

Toxicity screening of a novel poly(methylmethacrylate)-Eudragit nanocarrier on L929 fibroblasts

Graça, D., Louro, H., Santos, J., Dias, K., Almeida, A. J., Gonçalves, L., Silva, M. J. & Bettencourt, A., 5 Jul 2017, In: Toxicology Letters. 276, p. 129-137 9 p.

Research output: Contribution to journal › Article › peer-review

13 Citations (Scopus)

2016

Challenges in risk assessment of multiple mycotoxins in food

Assuncao, R., Silva, M. J. & Alvito, P., 2016, In: World Mycotoxin Journal. 9, 5, SI, p. 791-811 21 p.

Research output: Contribution to journal › Article › peer-review

63 Citations (Scopus)

Evaluation of the cytotoxic and genotoxic effects of benchmark multi-walled carbon nanotubes in relation to their physicochemical properties

Louro, H., Pinhão, M., Santos, J., Tavares, A., Vital, N. & Silva, M. J., 16 Nov 2016, In: Toxicology Letters. 262, p. 123-134 12 p.

Research output: Contribution to journal › Article › peer-review

41 Citations (Scopus)

Ochratoxin A-induced cytotoxicity, genotoxicity and reactive oxygen species in kidney cells: An integrative approach of complementary endpoints

Costa, J. G., Saraiva, N., Guerreiro, P. S., Louro, H., Silva, M. J., Miranda, J. P., Castro, M., Batinic-Haberle, I., Fernandes, A. S. & Oliveira, N. G., Jan 2016, In: Food and Chemical Toxicology. 87, p. 65-76 12 p.

Research output: Contribution to journal › Article › peer-review

90 Citations (Scopus)

2015

Exploring the potential interference of estuarine sediment contaminants with the DNA repair capacity of human hepatoma cells

Pinto, M. F., Louro, H., Costa, P. M., Caeiro, S. & Silva, M. J., 3 May 2015, In: Journal of Toxicology and Environmental Health. 78, 9, p. 559-570 12 p.

Research output: Contribution to journal › Article › peer-review

9 Citations (Scopus)

2014

Integrated approach to the in vivo genotoxic effects of a titanium dioxide nanomaterial using LacZ plasmid-based transgenic mice

Louro, H., Tavares, A., Vital, N., Costa, P. M., Alverca, E., Zwart, E., de Jong, W. H., Fessard, V., Lavinha, J. & Silva, M. J., 2014, In: Environmental And Molecular Mutagenesis. 55, 6, p. 500-509 10 p.

Research output: Contribution to journal › Article › peer-review

22 Citations (Scopus)

2008

Mutagenic effects of poly (ADP-ribose) polymerase-1 deficiency in transgenic mice

Louro, H., Pinheiro, I., Costa, P., Sousa, C., Dias, A., Boavida, M. G. & Silva, M. J., 2 Apr 2008, In: Mutation Research - Fundamental and Molecular Mechanisms of Mutagenesis. 640, 1-2, p. 82-88 7 p.

Research output: Contribution to journal › Article › peer-review

7 Citations (Scopus)

2005

Comparative analysis of the mutagenic activity of oxaliplatin and cisplatin in the Hprt gene of CHO cells

Silva, M. J., Costa, P., Dias, A., Valente, M., Louro, H. & Boavida, M. G., 1 Aug 2005, In: Environmental And Molecular Mutagenesis. 46, 2, p. 104-115 12 p.

Research output: Contribution to journal › Article › peer-review