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Research Output at NOVA 1990 2018

Article
15 Citations (Scopus)

293 Cell Cycle Synchronisation In Adenovirus Vector Production

Carrondo, M. J. T. & Alves, P. M., 1 Jan 2009, In : Biotechnology Progress. 25, 1, p. 235-243

Research output: Contribution to journalArticle

Open Access
6 Citations (Scopus)
Open Access
26 Citations (Scopus)

Adenovirus purification by two-column, size-exclusion, simulated countercurrent chromatography

Nestola, P., Silva, R. J. S., Peixoto, C., Alves, P. M., Carrondo, M. J. T. & Mota, J. P. B., 20 Jun 2014, In : Journal Of Chromatography A. 1347, p. 111-121 11 p.

Research output: Contribution to journalArticle

Countercurrent Distribution
Distillation columns
Chromatography
Adenoviridae
Purification
3 Citations (Scopus)
8 Downloads (Pure)

A detection and quantification label-free tool to speed up downstream processing of model mucins

Carvalho, S. B., Moreira, A. S., Gomes, J., Carrondo, M. J. T., Thornton, D. J., Alves, P. M., Costa, J. & Peixoto, C., 1 Jan 2018, In : PLoS ONE. 13, 1, e0190974.

Research output: Contribution to journalArticle

Open Access
File
mucins
Mucins
Labels
lectins
Processing
118 Citations (Scopus)
Open Access
8 Citations (Scopus)
Open Access
61 Citations (Scopus)
Open Access
8 Citations (Scopus)

Bioorthogonal Strategy for Bioprocessing of Specific-Site-Functionalized Enveloped Influenza-Virus-Like Particles

Carvalho, S. B., Freire, J. M., Moleirinho, M. G., Monteiro, F., Gaspar, D., Castanho, M. A. R. B., Carrondo, M. J. T., Alves, P. M., Bernardes, G. J. L. & Peixoto, C., 19 Oct 2016, In : Bioconjugate Chemistry. 27, 10, p. 2386-2399 14 p.

Research output: Contribution to journalArticle

Orthomyxoviridae
Viruses
Virion
Vaccines
Azides
11 Citations (Scopus)

Bioprocess integration for human mesenchymal stem cells: From up to downstream processing scale-up to cell proteome characterization

Cunha, B., Aguiar, T., Carvalho, S. B., Silva, M. M., Gomes, R. A., Carrondo, M. J. T., Gomes-Alves, P., Peixoto, C., Serra, M. & Alves, P. M., 20 Apr 2017, In : Journal of Biotechnology. 248, p. 87-98 12 p.

Research output: Contribution to journalArticle

Proteome
Stem cells
Mesenchymal Stromal Cells
Proteins
Processing
19 Citations (Scopus)
Open Access
Bioreactors
Cluster Analysis
Population
5 Citations (Scopus)
Recombinant proteins
Baculoviridae
Cell death
Recombinant Proteins
Catalase
68 Citations (Scopus)
Open Access
Baculoviridae
Metabolism
Insects
Cell Count
Sf9 Cells
2 Citations (Scopus)
1 Downloads (Pure)

Clinical-grade oncolytic adenovirus purification using polysorbate 20 as an alternative for cell lysis

Moleirinho, M. G., Rosa, S., Carrondo, M. J. T., Silva, R. J. S., Hagner-McWhirter, Å., Ahlén, G., Lundgren, M., Alves, P. M. & Peixoto, C., 1 Jan 2018, In : Current Gene Therapy. 18, 6, p. 366-374 9 p.

Research output: Contribution to journalArticle

Open Access
File
Polysorbates
Octoxynol
Adenoviridae
Clinical Trials, Phase I
Surface-Active Agents
30 Citations (Scopus)

Combining Hypoxia and Bioreactor Hydrodynamics Boosts Induced Pluripotent Stem Cell Differentiation Towards Cardiomyocytes

Correia, C., Serra, M., Espinha, N., Sousa, M., Montes, A. C., Burkert, K., Zheng, Y., Hescheler, J., Carrondo, M. J. T., Šarić, T. & Alves, P. M., 2014, In : Stem Cell Reviews and Reports. 10, 6, p. 786-801 16 p.

Research output: Contribution to journalArticle

Induced Pluripotent Stem Cells
Bioreactors
Hydrodynamics
Cardiac Myocytes
Cell Differentiation
7 Citations (Scopus)

Combining stable insect cell lines with baculovirus-mediated expression for multi-HA influenza VLP production

Sequeira, D. P., Correia, R., Carrondo, M. J. T., Roldão, A., Teixeira, A. P. & Alves, P. M., 24 May 2018, In : Vaccine. 36, 22(SI), p. 3112-3123 12 p.

Research output: Contribution to journalArticle

virus-like particles
Baculoviridae
Hemagglutinins
hemagglutinins
Orthomyxoviridae
2 Citations (Scopus)

Disclosing the Parameters Leading to High Productivity of Retroviral Producer Cells Lines: Evaluating Random Versus Targeted Integration

Bandeira, V. S., Tomás, H. A., Alici, E., Carrondo, M. J. T. & Coroadinha, A. S., 1 Apr 2017, In : Human Gene Therapy Methods. 28, 2, p. 78-90 13 p.

Research output: Contribution to journalArticle

Gibbon ape leukemia virus
Transgenes
Cell Line
Gammaretrovirus
env Genes
6 Citations (Scopus)
Open Access
25 Citations (Scopus)
Open Access
2 Citations (Scopus)
Microfiltration
Fermentation
Fermenters
Theology
Viscosity
261 Citations (Scopus)
Hydrogen Sulfide
Hydrogen sulfide
Sulfates
Bacteria
Growth
48 Citations (Scopus)
Open Access
Baculoviridae
Costs and Cost Analysis
Endpoint Determination
Workflow
Infection
10 Citations (Scopus)

Evaluation of novel large cut-off ultrafiltration membranes for adenovirus serotype 5 (Ad5) concentration

Nestola, P., Martins, D. L., Peixoto, C., Roederstein, S., Schleuss, T., Alves, P. M., Mota, J. P. B. & Carrondo, M. J. T., 29 Dec 2014, In : PlosOne. 9, 12, e115802.

Research output: Contribution to journalArticle

Ultrafiltration
Adenoviridae
ultrafiltration
Viruses
serotypes
14 Citations (Scopus)
Desulfovibrio
Hydrogen Sulfide
Sulfates
Bacteria
9 Citations (Scopus)

Exploring analytical proteomics platforms toward the definition of human cardiac stem cells receptome

Gomes-Alves, P., Serra, M., Montes, A. C., R.-Borlado, L., López, J. A., Vázquez, J., Carrondo, M. J. T., Bernad, A. & Alves, P. M., 1 Apr 2015, In : Proteomics. 15, 7, p. 1332-1337 6 p.

Research output: Contribution to journalArticle

Cell membranes
Stem cells
Proteomics
Stem Cells
Cell Membrane
28 Citations (Scopus)

Exploring continuous and integrated strategies for the up- and downstream processing of human mesenchymal stem cells

Cunha, B., Aguiar, T., Silva, M. M., Silva, R. J. S., Sousa, M. F. Q., Pineda, E., Peixoto, C., Carrondo, M. J. T., Serra, M. & Alves, P. M., 10 Nov 2015, In : Journal of Biotechnology. 213, p. 97-108 12 p.

Research output: Contribution to journalArticle

Stem cells
Mesenchymal Stromal Cells
Processing
Cell death
Perfusion
2 Citations (Scopus)

Extracellular Purine and Pyrimidine Catabolism in Cell Culture

Carrondo, M., 1 Jan 2011, In : Biotechnology Progress. 27, 5, p. 1373-1382

Research output: Contribution to journalArticle

Open Access
20 Citations (Scopus)

Filtration methodologies for the clarification and concentration of human mesenchymal stem cells

Cunha, B., Peixoto, C., Silva, M. M., Carrondo, M. J. T., Serra, M. & Alves, P. M., 5 Mar 2015, In : Journal of Membrane Science. 478, p. 117-129 13 p.

Research output: Contribution to journalArticle

stem cells
Stem cells
Mesenchymal Stromal Cells
methodology
cells
3 Citations (Scopus)

Finding the design space of a filtration-based operation for the concentration of human pluripotent stem cells

Cunha, B., Silva, R. J. S., Correia, C., Koshkin, A., Alves, P. M., Serra, M., Peixoto, C. & Carrondo, M. J. T., 1 Jan 2017, In : Journal of Membrane Science. 542, p. 399-407 9 p.

Research output: Contribution to journalArticle

Pluripotent Stem Cells
stem cells
Induced Pluripotent Stem Cells
Stem cells
Shear deformation
7 Citations (Scopus)
Open Access
25 Citations (Scopus)
Open Access
7 Citations (Scopus)

Human amniocyte-derived cells are a promising cell host for adenoviral vector production under serum-free conditions

Silva, A. C., Simão, D., Küppers, C., Lucas, T., Sousa, M. F. Q., Cruz, P., Carrondo, M. J. T., Kochanek, S. & Alves, P. M., 1 May 2015, In : Biotechnology Journal. 10, 5, p. 760-771 12 p.

Research output: Contribution to journalArticle

Adenoviridae
Cell Count
Cell Line
Infection
Serum
101 Citations (Scopus)
Open Access
48 Citations (Scopus)

Hybrid elementary flux analysis/nonparametric modeling: application for bioprocess control

Alves, P. M., Carrondo, M. J. T., Oliveira, R. M. F. & DQ Group Author, 1 Jan 2007, In : BMC Bioinformatics. 8, NA, p. n/d

Research output: Contribution to journalArticle

Open Access
Bioreactors
Metabolic Networks and Pathways
Glutamine
Glucose
Information Systems

Hybrid metabolic flux analysis/data-driven modelling of bioprocesses

Teixeira, A., Alves, C. M. L., Alves, P. M., Carrondo, M. J. T. & Oliveira, R., 1 Dec 2006, In : Computer Aided Chemical Engineering. 21, C, p. 1667-1672 6 p.

Research output: Contribution to journalArticle

Data structures
Fluxes
Bioreactors
Metabolism
Kinetics
18 Citations (Scopus)
Open Access
Systems Biology
Process engineering
Biological systems
Animal cell culture
Metabolites
12 Citations (Scopus)

Impact of grafting on the design of new membrane adsorbers for adenovirus purification

Nestola, P., Villain, L., Peixoto, C., Martins, D. L., Alves, P. M., Carrondo, M. J. T. & Mota, J. P. B., 10 Jul 2014, In : Journal of Biotechnology. 181, p. 1-11

Research output: Contribution to journalArticle

Open Access
Adenoviridae
Purification
Membranes
Viruses
Hydrogel
16 Citations (Scopus)
Open Access
103 Citations (Scopus)
Open Access
Bioreactors
Stem cells
Oxygen
Metabolism
Industrial applications
8 Citations (Scopus)

Improving washing strategies of human mesenchymal stem cells using negative mode expanded bed chromatography

Cunha, B., Silva, R. J. S., Aguiar, T., Serra, M., Daicic, J., Maloisel, J. L., Clachan, J., Åkerblom, A., Carrondo, M. J. T., Peixoto, C. & Alves, P. M., 15 Jan 2016, In : Journal Of Chromatography A. 1429, p. 292-303 12 p.

Research output: Contribution to journalArticle

Chromatography
Stem cells
Mesenchymal Stromal Cells
Washing
Adsorption
24 Citations (Scopus)
Acetic acid
Acetic Acid
Sulfates
Bacteria
Growth
17 Citations (Scopus)

Influence of sulfates and operational parameters on volatile fatty acids concentration profile in acidogenic phase

Reis, M. A. M., Lemos, P. C., Martins, M. J., Costa, P. C., Gonçalves, L. M. D. & Carrondo, M. J. T., 1 Apr 1991, In : Bioprocess Engineering. 6, 4, p. 145-151 7 p.

Research output: Contribution to journalArticle

Volatile Fatty Acids
Sulfates
Acetic Acid
Bacteria
Butyric Acid
46 Citations (Scopus)

Insect cells as production platform of complex virus-like particles

Fernandes, F., Teixeira, A. P., Carinhas, N., Carrondo, M. J. T. & Alves, P. M., 1 Jan 2013, In : Expert Review of Vaccines. 12, 2, p. 225-236

Research output: Contribution to journalArticle

Open Access
Virion
Insects
Viral Structural Proteins
Baculoviridae
Viral Genome
52 Citations (Scopus)
Open Access
Recombinant proteins
Fluorometry
Glycoproteins
Cell culture
Recombinant Proteins
13 Citations (Scopus)
Open Access
Rotavirus
Viral Proteins
Proteins
Viral DNA
Coinfection
8 Citations (Scopus)

In vitro expansion of human cardiac progenitor cells: Exploring 'omics tools for characterization of cell-based allogeneic products

Gomes-Alves, P., Serra, M., Brito, C., Ricardo, C. P., Cunha, J. R., Sousa, M. F., Teresa Blazquez-Sanchez, M., Bernad, A., Carrondo, M. J. T., Rodriguez-Borlado, L. & Alves, P. M., 1 May 2016, In : Translational Research. 171, p. 96-110 15 p.

Research output: Contribution to journalArticle

Stem cells
Stem Cells
Monolayers
Production platforms
Proteome
22 Citations (Scopus)
Liquid membranes
Ion Exchange
Mass transfer
membranes
Kinetics