• 3143 Citations
  • 32 h-Index
1990 …2019

Research output per year

If you made any changes in Pure these will be visible here soon.

Personal profile

Research interests

Upstream and downstream processes with physico – mathematical tools towards the development of bioprocesses for complex and novel biopharmaceuticals. Simplicity, feasibility, transferability and economics are criteria used to design processes that may find industrialization opportunities. Such criteria, design and process applications have been extended to vaccines (e.g. multivalent Influenza VLPs, retro-VLPs, HIG Gag-VLPs, ZIKV-VLPs, viral vaccines…) and viral vectors for gene therapy (e.g. adenoviruses, retroviruses, lentiviruses, AAVs,…), drawing from the expertise and research achievements of the other labs in the ACTU.

Optimization of mammalian and insect cells expression systems (stable or transient expression), evaluation of different bioreactor operation modes (e.g. fed-batch and perfusion), application of scale-down models for high-throughput screening, design of novel continuous purification processes, modelling towards biological and chemical process control, and scale-up for pre-clinical applications. More recently, metabolic systems biology (e.g. 13C tracer experiments for fluxome estimation and exometabolome profiling by 1H-NMR) has been assisting bioprocess development in areas such as cancer cell metabolism (e.g. lung and breast), brain cell metabolism in normal and pathological conditions, stem cell metabolism along cardiac and neural differentiation, and cell metabolic response to virus infection.

Keywords: Biopharmaceuticals, Vaccines, Virus, Proteins, Stem cells, Gene Therapy, Engineering, Process Development, GMP

Fingerprint Dive into the research topics where Manuel José Teixeira Carrondo is active. These topic labels come from the works of this person. Together they form a unique fingerprint.

  • 9 Similar Profiles

Network Recent external collaboration on country level. Dive into details by clicking on the dots.

Research Output at NOVA

Current challenges in biotherapeutic particles manufacturing

Moleirinho, M. G., Silva, R. J. S., Alves, P. M., Carrondo, M. J. T. & Peixoto, C., 1 Jan 2019, (Accepted/In press) In : Expert Opinion on Biological Therapy.

Research output: Contribution to journalReview article

Open Access
  • 6 Citations (Scopus)

    Efficient filtration strategies for the clarification of influenza virus-like particles derived from insect cells

    Carvalho, S. B., Silva, R. J. S., Moreira, A. S., Cunha, B., Clemente, J. J., Alves, P. M., Carrondo, M. J. T., Xenopoulos, A. & Peixoto, C., 1 Jul 2019, In : Separation and Purification Technology. 218, p. 81-88 8 p.

    Research output: Contribution to journalArticle

  • 7 Citations (Scopus)
  • 2 Citations (Scopus)
  • 3 Citations (Scopus)

    Flexible 3d cell-based platforms for the discovery and profiling of novel drugs targeting plasmodium hepatic infection

    Arez, F., Rebelo, S. P., Fontinha, D., Simaõ, D., Martins, T. R., MacHado, M., Fischli, C., Oeuvray, C., Badolo, L., Carrondo, M. J. T., Rottmann, M., Spangenberg, T., Brito, C., Greco, B., Prudêncio, M. & Alves, P. M., 8 Nov 2019, In : ACS Infectious Diseases . 5, 11, p. 1831-1842 12 p.

    Research output: Contribution to journalArticle

  • 4 Citations (Scopus)