Research output

Research output per year 2005 2020

• 1377 Citations
• 19 h-Index
• 22 Article
• 11 Abstract
• 7 Poster
• 5 Chapter
• 7 More
  • 2 Meeting Abstract
  • 2 Review article
  • 1 Paper
  • 1 Book/Film/Article review
  • 1 Doctoral Thesis

Research output per year

Research output per year

Search results

• 2020

  Efflux pump inhibitors as a promising adjunct therapy against drug resistant tuberculosis: a new strategy to revisit mycobacterial targets and repurpose old drugs

  Rodrigues, L., Cravo, P. & Viveiros, M., 2 Aug 2020, In : Expert Review of Anti-Infective Therapy. Vol. 18, n.º 8, p. 741-757 17 p.

  Research output: Contribution to journal › Review article

  Open Access

  File

  • Drug Repositioning
  • Multidrug-Resistant Tuberculosis
  • Drug Resistance
  • Mycobacterium tuberculosis
  • Pharmaceutical Preparations
  4 Citations (Scopus)

  6 Downloads (Pure)

• Targeting membrane transporters and energy metabolism in Mycobacterium tuberculosis through in silico drug repurposing

  Rodrigues, L., Cravo, P. V. L. & Viveiros, M., 2020.

  Research output: Contribution to conference › Poster
• 2019

  Chemogenomics and in silico repurposing as an innovative approach for rapid drug discovery in tuberculosis

  Rodrigues, L., Cravo, P. & Viveiros, M., 2019.

  Research output: Contribution to conference › Abstract

• In silico repurposing of approved drugs against tuberculosis: targeting membrane transporters and energy metabolism

  Rodrigues, L., Cravo, P. & Viveiros, M., 2019.

  Research output: Contribution to conference › Abstract

• O contributo dos serviços de diagnóstico laboratorial para o acesso universal à saúde nos países da Comunidade de Língua Portuguesa

  ML, V., Rodrigues, L., Almeida, F., Fortes, F., Germano de, S., Sandra, M., Silveira, H. & Viveiros, M., 5 Dec 2019, In : Anais do Instituto de Higiene e Medicina Tropical. 18, p. 42-51 10 p.

  Research output: Contribution to journal › Article

  Open Access

  • Cabo Verde
  • Health Services
  • Angola
  • Public Health
  • Portugal

• Targeting membrane transporters and energy metabolism in Mycobacterium tuberculosis using an in silico repurposing-chemogenomics strategy

  Rodrigues, L., Cravo, P. V. L. & Viveiros, M., 2019.

  Research output: Contribution to conference › Poster
• 2017

  New strategies to fight MDR-TB: from early detection to innovative drug discovery

  Couto, I. & Rodrigues, L., 2017.

  Research output: Contribution to conference › Abstract
• 2015

  Measuring efflux and permeability in Mycobacteria

  Rodrigues, L. I. D., Viveiros, M. & Aínsa, J., 2015, Methods in molecular biology: mycobacteria protocols. Parish, T. & Roberts, D. M. (eds.). 2015 ed. New York: Springer Science Business Media, Vol. 1285. p. 227-239 13 p.

  Research output: Chapter in Book/Report/Conference proceeding › Chapter

  • Mycobacterium
  • Cell Wall
  • Permeability
  • Cells
  • Pumps
  17 Citations (Scopus)
• 2014

  A simple method based on a reliable genetic marker for identification of Mycobacterium tuberculosis Beijing genotype

  Fuentes, D., Villellas, C., Vitoria, M. A., Samper, S., Aínsa, J. A. & Rodrigues, L., 2014.

  Research output: Contribution to conference › Poster
• 2013

  Role of the Mmr efflux pump in drug resistance in Mycobacterium tuberculosis.

  Rodrigues, L., Villellas, C., Bailo, R., Bettencourt, M. V. & Aínsa, J. A., 1 Jan 2013, In : Antimicrobial Agents and Chemotherapy. 57, 2, p. 751-757

  Research output: Contribution to journal › Article

  Open Access

  • Ethidium
  • Isoniazid
  • Mycobacterium tuberculosis
  • Drug Resistance
  • Cetrimonium
  52 Citations (Scopus)

• Significance of efflux in multidrug resistance in Mycobacterium tuberculosis

  Viveiros, M., Rodrigues, L., Machado, D., Martins, M., Couto, I. & Amaral, L., 2013.

  Research output: Contribution to conference › Abstract

• Targeting multidrug efflux pumps in Mycobacterium tuberculosis

  Rodrigues, L., 2013.

  Research output: Contribution to conference › Abstract
• 2012

  Contribution of efflux activity to isoniazid resistance in the Mycobacterium tuberculosis complex

  Rodrigues, L., Machado, D., Couto, I., Amaral, L. & Viveiros, M., Jun 2012, In : Infection, Genetics and Evolution. 12, 4, p. 695-700 6 p.

  Research output: Contribution to journal › Article

  • Mycobacterium tuberculosis complex
  • isoniazid
  • tuberculosis
  • Isoniazid
  • Mycobacterium tuberculosis
  93 Citations (Scopus)

• Contribution of Efflux to the Emergence of Isoniazid and Multidrug Resistance in Mycobacterium tuberculosis.

  Machado, D., Couto, I. M. D. S. L., Perdigão, J., Rodrigues, L., Portugal, I., Baptista, P., Veigas, B., Amaral, L. & Bettencourt, M. V., 6 Apr 2012, In : PLoS ONE. 7, 4, e34538.

  Research output: Contribution to journal › Article

  Open Access
  145 Citations (Scopus)

• Genetic regulation, physiology, assessment and inhibition of efflux pumps responsible for multi-drug resistant phenotypes of bacterial pathogens

  Amaral, L., Fanning, S., Spengler, G., Rodrigues, L., Iversen, C., Martins, M., Martins, A., Viveiros, M. & Couto, I., 1 Aug 2012, Bacterial Pathogens: Virulence Mechanisms, Diagnosis and Management. Nova Science Publishers, Inc., p. 91-116 26 p.

  Research output: Chapter in Book/Report/Conference proceeding › Chapter

  • Pathogens
  • Physiology
  • Pumps
  • Phenotype
  • Bacteria

• Genetic response of Salmonella enterica serotype Enteritidis to thioridazine rendering the organism resistant to the agent.

  Spengler, G., Rodrigues, L., Martins, A., Martins, M., McCusker, M., Cerca, P., Machado, L., Costa, SS., Ntokou, E., Couto, I., Viveiros, M., Fanning, S., Molnar, J. & Amaral, L., 1 Jan 2012, In : International Journal Of Antimicrobial Agents. 39, 1, p. 16-21

  Research output: Contribution to journal › Article

  Open Access
  20 Citations (Scopus)

• Inhibitors of mycobacterial efflux pumps as potential boosters for anti-tubercular drugs.

  Bettencourt, M. V., Martins, M., Rodrigues, L., Machado, D., Couto, I. M. D. S. L., Aínsa, J. A. & Amaral, L., 1 Jan 2012, In : Expert Review of Anti-Infective Therapy. 10, 9, p. 983-998

  Research output: Contribution to journal › Article

  Open Access

  • Macrophages
  • Pumps
  • Anti-Bacterial Agents
  • Mutation
  • Bacteria
  61 Citations (Scopus)

• Novel compounds active against Mycobacterium tuberculosis: testing competitive inhibitors of type II dehydroquinase

  Begoña, G. & Rodrigues, L., 2012.

  Research output: Contribution to conference › Abstract

• Stress response and resistance of Salmonella enterica serotype Enteritidis to the efflux pump inhibitor neuropleptic drug thioridazine

  Spengler, G., Rodrigues, L., Martins, M., McCusker, M., Costa, SS., Ntokou, E., Szabo, Á. M., Horváth, Á., Varga, Z. G., Fanning, S., Molnár, J. & Amaral, L., 31 Mar 2012, p. P1224.

  Research output: Contribution to conference › Poster

• Structure, genetic regulation, physiology and function of the acrab-tolc efflux pump of escherichia coli and salmonella

  Amaral, L., Martins, A., Spengler, G., Martins, M., Rodrigues, L., McCusker, M., Ntokou, E., Cerca, P., Machado, L., Viveiros, M., Couto, I., Fanning, S., Kristiansen, J. & Molnar, J., 31 Aug 2012, Antimicrobial drug discovery: emerging strategies. Tegos, A. & Mylonakis, E. (eds.). CABI Publishing, p. 44-61 18 p.

  Research output: Chapter in Book/Report/Conference proceeding › Chapter

  • Salmonella
  • Phenothiazines
  • Genetic Structures
  • Escherichia coli
  • Physiology
  1 Citation (Scopus)
• 2011

  Ethidium bromide transport across Mycobacterium smegmatis cell-wall: correlation with antibiotic resistance.

  Rodrigues, L., Ramos, J., Couto, I. M. D. S. L., Amaral, L. & Bettencourt, M. V., 1 Jan 2011, In : Bmc Microbiology. 11, p. 35

  Research output: Contribution to journal › Article

  Open Access

  • Mycobacterium smegmatis
  • Porins
  • Ethidium
  • Cell Wall
  • Microbial Drug Resistance
  70 Citations (Scopus)

• Genetic regulation, physiology, assessment and inhibition of efflux pumps responsible for multi-drug resistant phenotypes of bacterial pathogens

  Amaral, L., Fanning, S., Spengler, G., Rodrigues, L., Iversen, C., Martins, M., Martins, A., Viveiros, M. & Couto, I., 1 Feb 2011, Antibiotic Resistance: Causes and Risk Factors, Mechanisms and Alternatives. Nova Science Publishers, Inc., p. 313-332 20 p.

  Research output: Chapter in Book/Report/Conference proceeding › Chapter

  • Pathogens
  • Physiology
  • Pumps
  • Phenotype
  • Bacteria
  3 Citations (Scopus)

• Inhibition of drug efflux in mycobacteria with phenothiazines and other putative efflux inhibitors

  Rodrigues, L., Aínsa, J. A., Amaral, L. & Bettencourt, M. V., May 2011, In : Recent Patents On Anti-Infective Drug Discovery. 6, 2, p. 118-127 10 p.

  Research output: Contribution to journal › Book/Film/Article review

  • Phenothiazines
  • Mycobacterium
  • Drug Resistance
  • Pharmaceutical Preparations
  • Tuberculosis
  37 Citations (Scopus)
• 2010

  Contribution of efflux activity to isoniazid resistance in Mycobacterium tuberculosis complex. (1)

  Rodrigues, L., Machado, D., Couto, I., Amaral, L. & Viveiros, M., 2010.

  Research output: Contribution to conference › Poster

  • Isoniazid
  • Mycobacterium tuberculosis
  • Pumps
  • Genes
  • Ethidium

• Contribution of the Mmr efflux pump to antimicrobial resistance in M. tuberculosis: construction of a mmr knockout mutant by allelic exchange.

  Bettencourt, M. V. & Rodrigues, L., 1 Jan 2010.

  Research output: Contribution to conference › Abstract

• Efflux pumps of bacteria and cancer cells: structure, genetic regulation in response to an agent; physiochemical mechanisms and clinical relevance

  Amaral, L., Spengler, G., Rodrigues, L., Martins, A., Martins, M., Costa, SS., Couto, I. & Viveiros, M., Apr 2010.

  Research output: Contribution to conference › Paper

• Evaluation of efflux activity of bacteria by a semi-automated fluorometric system

  Viveiros, M., Rodrigues, L., Martins, M., Couto, I., Spengler, G., Martins, A. & Amaral, L., 3 Mar 2010, In : Methods In Molecular Biology (Clifton, N.J.). 642, p. 159-172 14 p.

  Research output: Contribution to journal › Article

  • Bacteria
  • Ethidium
  • Phosphates
  • Enterobacter aerogenes
  • Mycobacterium smegmatis
  63 Citations (Scopus)

• Genetic regulation, physiology, assessment and inhibition of efflux pumps responsible for multi-drug resistant phenotypes of bacterial pathogens

  Amaral, L., Fanning, S., Spengler, G., Rodrigues, L., Iversen, C., Martins, M., Martins, A., Viveiros, M. & Couto, I., 1 Jan 2010, Multiple drug resistance. New York: Nova Science Publishers, Inc., p. 225-244

  Research output: Chapter in Book/Report/Conference proceeding › Chapter

  • Pathogens
  • Physiology
  • Pumps
  • Phenotype
  • Bacteria

• Identification of nontuberculous mycobacteria in clinical samples using molecular methods: a 3-year study.

  Couto, I. M. D. S. L., Machado, D., Bettencourt, M. V., Rodrigues, L. & Amaral, L., 1 Jan 2010, In : Clinical Microbiology and Infection. 16, 8, p. 1161-1164

  Research output: Contribution to journal › Article

  Open Access

  • Clinical laboratories
  • Pathogens
  • Nontuberculous Mycobacteria
  • Assays
  • Mycobacterium avium Complex
  21 Citations (Scopus)

• Molecular tools for rapid identification and novel effective therapy against MDRTB/XDRTB infections.

  Bettencourt, M. V., Martins, M., Couto, I. M. D. S. L., Rodrigues, L., Machado, D., Portugal, I. & Amaral, L., 1 Jan 2010, In : Expert Review of Anti-Infective Therapy. 8, 4, p. 465-80

  Research output: Contribution to journal › Article

  Open Access

  • Macrophages
  • Alveolar Macrophages
  • Mycobacterium tuberculosis
  • Portugal
  • Tuberculosis
  13 Citations (Scopus)

• Mutational and physiological dynamic of drug resistance in Mycobacterium tuberculosis, OP-8.

  Machado, D., Couto, I. M. D. S. L., Rodrigues, L., Amaral, L. & Bettencourt, M. V., 1 Jan 2010.

  Research output: Contribution to conference › Abstract

• Phenothiazines, bacterial efflux pumps and targeting the macrophage for enhanced killing of intracellular XDRTB

  Amaral, L., Martins, A., Molnár, J., Kristiansen, J. E., Martins, M., Viveiros, M., Rodrigues, L., Spengler, G., Couto, I., Ramos, J., Dastidar, S., Fanning, S., McCusker, M. & Pagès, J. M., Jun 2010, In : In Vivo. 24, 4, p. 409-424 16 p.

  Research output: Contribution to journal › Article

  • Macrophages
  • Phenothiazines
  • phenothiazine
  • Cell membranes
  • Pumps
  39 Citations (Scopus)

• Physiological characterisation of the efflux pump system of antibiotic-susceptible and multidrug-resistant Enterobacter aerogenes.

  Martins, A., Spengler, G., Martins, M., Rodrigues, L., Viveiros, M., Davin-Regli, A., Chevalier, J., Couto, I., Pagès, J. M. & Amaral, L., 1 Jan 2010, In : International Journal Of Antimicrobial Agents. 36, 4, p. 313-318

  Research output: Contribution to journal › Article

  Open Access

  • Enterobacter aerogenes
  • Pumps
  • Proton-Motive Force
  • Anti-Bacterial Agents
  • beta-Lactam Resistance
  10 Citations (Scopus)

• The role of the efflux mechanisms in multidrug resistance in Mycobacterium tuberculosis

  Rodrigues, L., 2010, Lisboa. 258 p.

  Research output: Thesis › Doctoral Thesis

  • Multiple Drug Resistance
  • Mycobacterium tuberculosis
  • Tuberculosis
  • Mycobacterium smegmatis
  • Escherichia coli
• 2009

  An AcrAB-mediated multidrug-resistant phenotype is maintained following restoration of wild-type activities by efflux pump genes and their regulators

  Martins, A., Iversen, C., Rodrigues, L., Spengler, G., Ramos, J., Kern, W. V., Couto, I., Viveiros, M., Fanning, S., Pagès, J. M. & Amaral, L., 1 Jan 2009, In : International Journal Of Antimicrobial Agents. 34, 6, p. 602-604

  Research output: Contribution to journal › Article

  Open Access

  • Tetracycline
  • Regulator Genes
  • Restoration
  • Genes
  • Pumps
  25 Citations (Scopus)

• Characterization of efflux pumps of mycobacteria by real-time RT-PCR and a semi-automated fluorometric method

  Rodrigues, L., 2009.

  Research output: Contribution to conference › Abstract

• Characterization of intrinsic efflux activity of Enterococcus faecalis ATCC29212 by a semi-automated ethidium bromide method

  Spengler, G., Martins, A., Schelz, Z., Rodrigues, L., Aagaard, L., Martins, M., Costa, S. S., Couto, I., Viveiros, M., Fanning, S., Kristiansen, J. E., Molnar, J. & Amaral, L., 1 Jan 2009, In : In Vivo. 23, 1, p. 81-87 7 p.

  Research output: Contribution to journal › Article

  • Ethidium
  • Enterococcus faecalis
  • Protons
  • Anti-Bacterial Agents
  • Carbonyl Cyanide m-Chlorophenyl Hydrazone
  12 Citations (Scopus)

• Contribution of efflux pump activity of macrolide resistance in M. avium complex.

  Rodrigues, L., Sampaio, D., Couto, I., Machado, D., Kern, W. V., Amaral, L. & Viveiros, M., 2009, p. 70.

  Research output: Contribution to conference › Abstract

  • Mycobacterium avium Complex
  • Macrolides
  • Pumps
  • Thioridazine
  • Clarithromycin

• Demonstration of the activity of P-glycoprotein by a semi-automated fluorometric method

  Spengler, G., Viveiros, M., Martins, M., Rodrigues, L., Martins, A., Molnar, J., Couto, I. & Amaral, L., Jun 2009, In : Anticancer Research. 29, 6, p. 2173-2177 5 p.

  Research output: Contribution to journal › Article

  • Ethidium
  • ATP Binding Cassette Transporter, Subfamily B, Member 1
  • Reserpine
  • ATP-Binding Cassette Transporters
  • Verapamil
  19 Citations (Scopus)

• Early detection of MDRTB by molecular tools in the control of drug resistant tuberculosis in Portugal: a case of success.

  Machado, D., Bettencourt, M. V., Rodrigues, L., Couto, I. M. D. S. L. & Amaral, L., 2009, p. 96.

  Research output: Contribution to conference › Poster

  • Portugal
  • Multidrug-Resistant Tuberculosis
  • Rifampin
  • Tuberculosis
  • Assays

• Efflux pumps in Escherichia coli and Mycobacterium sp.: Methods to assess their importance in multidrug resistance

  Rodrigues, L., 2009.

  Research output: Contribution to conference › Abstract

• Fluorometric determination of ethidium bromide efflux kinetics in Escherichia coli.

  Paixão, L., Rodrigues, L., Couto, I. M. D. S. L., Martins, M., Fernandes, P., de Carvalho, C. CCR., Monteiro, G. A., Sansonetty, F., Amaral, L. & Viveiros, M., 1 Jan 2009, In : Journal Of Biological Engineering. 3, 18.

  Research output: Contribution to journal › Article

  Open Access

  • Ethidium
  • Escherichia coli
  • Kinetics
  • Pumps
  • Bacteria
  93 Citations (Scopus)

• pH Modulation of efflux pump activity of multi-drug resistant Escherichia coli protection during its passage and eventual colonization of the colon

  Martins, A., Spengler, G., Rodrigues, L., Viveiros, M., Ramos, J., Martins, M., Couto, I., Fanning, S., Pagès, J. M., Bolla, J. M., Molnar, J. & Amaral, L., 17 Aug 2009, In : PlosOne. 4, 8, 9 p., e6656.

  Research output: Contribution to journal › Article

  Open Access

  • Ethidium
  • Escherichia coli
  • phenylalanylarginine
  • Colon
  • Modulation
  43 Citations (Scopus)

• The role of efflux pumps in macrolide resistance in Mycobacterium avium complex

  Rodrigues, L., Sampaio, D., Couto, I., Machado, D., Kern, W. V., Amaral, L. & Viveiros, M., 1 Jan 2009, In : International Journal Of Antimicrobial Agents. 34, 6, p. 529-533

  Research output: Contribution to journal › Article

  Open Access

  • Mycobacterium avium Complex
  • Macrolides
  • Pumps
  • Thioridazine
  • Ethidium
  43 Citations (Scopus)

• The role played by efflux pumps in macrolide resistance in Mycobacterium avium complex.

  Rodrigues, L., Sampaio, D., Couto, I. M. D. S. L., Machado, D., Kern, W. V., Amaral, L. & Bettencourt, M. V., 2009.

  Research output: Contribution to conference › Poster
• 2008

  Assessment and comparison of efflux pumps of cancer cells and MDR bacteria under physiological conditions by a real-time semi-automated system

  Amaral, L., Spengler, G., Viveiros, M., Rodrigues, L., Martins, A., Couto, I., Martins, M., Fanning, S., Pages, J-M. & Molnar, J., 2008, In : Anticancer Research. 28, 5C, p. 3193-3194 2 p.

  Research output: Contribution to journal › Meeting Abstract

• Demonstration of intrinsic efflux activity of Escherichia coli K-12 AG100 by an automated ethidium bromide method

  Viveiros, M., Martins, A., Paixão, L., Rodrigues, L., Martins, M., Couto, I., Fähnrich, E., Kern, W. V. & Amaral, L., May 2008, In : International Journal Of Antimicrobial Agents. Vol. 31, n.º 5, p. 458-462 5 p.

  Research output: Contribution to journal › Article

  • Ethidium
  • Escherichia coli
  • Libraries
  • Temperature
  • Glucose
  101 Citations (Scopus)

• Demonstration of the activity of P-Glycoprotein by a fully automated ethidium bromide method

  Spengler, G., Viveiros, M., Martins, A., Rodrigues, L., Martins, M., Molnar, J., Couto, I. & Amaral, L., 2008, In : Anticancer Research. 28, 5C, p. 3493-3493 1 p.

  Research output: Contribution to journal › Meeting Abstract

• New methods for the identification of efflux mediated MDR bacteria, genetic assessment of regulators and efflux pump constituents, characterization of efflux systems and screening for inhibitors of efflux pumps

  Viveiros, M., Martins, M., Couto, I., Rodrigues, L., Spengler, G., Martins, A., Kristiansen, J. E., Molnar, J. & Amaral, L., Sep 2008, In : Current Drug Targets. Vol. 9, n.º 9, p. 760-778 19 p.

  Research output: Contribution to journal › Review article

  • Bacteria
  • Screening
  • Pumps
  • Bacteriology
  • Genes
  41 Citations (Scopus)

• Thioridazine and chlorpromazine inhibition of ethidium bromide efflux in Mycobacterium avium and Mycobacterium smegmatis

  Rodrigues, L., Wagner, D., Viveiros, M., Sampaio, D., Couto, I., Vavra, M., Kern, W. V. & Amaral, L., May 2008, In : Journal of Antimicrobial Chemotherapy. 61, 5, p. 1076-1082 7 p.

  Research output: Contribution to journal › Article

  • Thioridazine
  • Mycobacterium smegmatis
  • Mycobacterium avium
  • Ethidium
  • Chlorpromazine
  92 Citations (Scopus)