• 548 Citations
  • 9 h-Index
20072019

Research output per year

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Personal profile

Research interests

Since my Ph.D. thesis my work has focused on the study of the mechanisms responsible for the emergence of drug resistance in bacteria, namely the contribution of efflux pumps. In particular, I have studied the contribution of efflux pumps in the development of drug resistance in Mycobacterium tuberculosis and other mycobacteria. Moreover, I was involved in the development of methods that allow the detection of efflux activity in bacteria and the in vitro testing of efflux inhibitors. I am also interested in the identification of new drugs, or adjuvants of already existent anti-tuberculosis drugs, that may be used as new therapeutical approaches. From 2011 to 2016, I worked as a post-doctoral researcher at the University of Zaragoza in Spain and was involved in the FP7 project More Medicines for Tuberculosis. Presently, I’m a Marie Curie Fellow (H2020-MSCA-IF-2017: iCHEMGENODRUGS_TB) at GHTM and my main research interest is to explore the novel concepts of drug repurposing and comparative chemogenomics to find new drugs against tuberculosis.

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Research Output at NOVA

Design, Synthesis, and Efficacy Testing of Nitroethylene- and 7-Nitrobenzoxadiazol-Based Flavodoxin Inhibitors against Helicobacter pylori Drug-Resistant Clinical Strains and in Helicobacter pylori-Infected Mice

Salillas, S., Alías, M., Michel, V., Mahía, A., Lucía, A., Rodrigues, L., Bueno, J., Galano-Frutos, J. J., De Reuse, H., Velázquez-Campoy, A., Carrodeguas, J. A., Sostres, C., Castillo, J., Aínsa, J. A., Díaz-De-Villegas, M. D., Lanas, Á., Touati, E. & Sancho, J., 7 Jun 2019, In : Journal Of Medicinal Chemistry. Vol. 62, n.º 13, p. 6102-6115 14 p.

Research output: Contribution to journalArticle

  • 5 Citations (Scopus)

    Mycobacterial aminoglycoside acetyltransferases: a little of drug resistance, and a lot of other roles

    Sanz-García, F., Anoz-Carbonell, E., Pérez-Herrán, E., Martín, C., Lucía, A., Rodrigues, L. & Aínsa, J. A., 30 Jan 2019, In : Frontiers in Microbiology. Vol. 10, n.º JAN, p. 46-57 11 p., 46.

    Research output: Contribution to journalArticle

    Open Access
  • 1 Citation (Scopus)

    O contributo dos serviços de diagnóstico laboratorial para o acesso universal à saúde nos países da Comunidade de Língua Portuguesa

    Translated title of the contribution: Laboratory services contribution to supporting public health and health services in Portuguese-speaking countriesML, V., Rodrigues, L., Almeida, F., Fortes, F., Germano de, S., Sandra, M., Silveira, H. & Viveiros, M., 5 Dec 2019, In : Anais do Instituto de Higiene e Medicina Tropical. Vol. 18, p. 42-51 10 p.

    Research output: Contribution to journalArticle

    Open Access
  • Boldine-derived Alkaloids inhibit the activity of DNA topoisomerase I and growth of Mycobacterium tuberculosis

    M. Teresa, G., David, C. D., José Manuel, T-V., María José, F., Rodrigues, L. I. D., Begoña, G., M., A., Aínsa, J. A. & Adela G., D. L. C. A. G., 24 Jul 2018, In : Frontiers in Microbiology. Vol. 9, JUL, p. p. 1659-1667 9 p., 1659.

    Research output: Contribution to journalArticle

    Open Access
  • Synergy between circular bacteriocin AS-48 and ethambutol against mycobacterium tuberculosis

    Aguilar-Pérez, C., Gracia, B., Rodrigues, L., Vitoria, A., Cebrián, R., Deboosère, N., Song, O. R., Brodin, P., Maqueda, M. & Aínsaa, J. A., 1 Sep 2018, In : Antimicrobial Agents and Chemotherapy. 62, 9, e00359-18.

    Research output: Contribution to journalArticle

  • 4 Citations (Scopus)