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Research Output at NOVA 1982 2019

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Article
2019
1 Downloads (Pure)
Open Access
File
MicroRNAs
Drug Resistance
Neoplasms
Small Untranslated RNA
3' Untranslated Regions
Open Access
File
MicroRNAs
Drug Resistance
Doxorubicin
Breast Neoplasms
Real-Time Polymerase Chain Reaction
1 Citation (Scopus)
Philadelphia Chromosome
Genetic Predisposition to Disease
Caspases
Population
Genes

Thyroid cancer: The quest for genetic susceptibility involving dna repair genes

Santos, L. S., Gomes, B. C., Bastos, H. N., Gil, O. M., Azevedo, A. P., Ferreira, T. C., Limbert, E., Silva, S. N. & Rueff, J., 1 Aug 2019, In : Genes. 10, 8, 586.

Research output: Contribution to journalArticle

Genetic Predisposition to Disease
Thyroid Neoplasms
Single Nucleotide Polymorphism
DNA Repair
Genes
2018
1 Citation (Scopus)
Critical Pathways
Hydroxyurea
Caspases
DNA Repair
Polymorphism
2 Citations (Scopus)
alternative medicine
herbal medicines
flavorings
Risk assessment
functional foods

Human cytochrome P450 expression in bacteria: Whole-cell high-throughput activity assay for CYP1A2, 2A6 and 3A4

Esteves, F., Campelo, D., Urban, P., Bozonnet, S., Lautier, T., Rueff, J., Truan, G. & Kranendonk, M., Dec 2018, In : Biochemical pharmacology. 158, p. 134-140 7 p.

Research output: Contribution to journalArticle

Cytochrome P-450 CYP1A2
Cytochromes
Cytochrome P-450 Enzyme System
Assays
Bacteria
1 Citation (Scopus)
4 Downloads (Pure)

Mismatch repair single nucleotide polymorphisms and thyroid cancer susceptibility

Santos, L. S., Silva, S. N., Gil, O. M., Ferreira, T. C., Limbert, E. & Rueff, J., May 2018, In : Oncology Letters. 15, 5, p. 6715-6726 12 p.

Research output: Contribution to journalArticle

Open Access
File
DNA Mismatch Repair
Thyroid Neoplasms
Single Nucleotide Polymorphism
Genotype
Genetic Predisposition to Disease
4 Downloads (Pure)
Open Access
File
NADPH-Ferrihemoprotein Reductase
hinges
cytochromes
Hinges
Cytochrome P-450 Enzyme System
Proximal Kidney Tubule
Facilitative Glucose Transport Proteins
Accessories
Glucose
Kidney
2017
3 Citations (Scopus)
14 Downloads (Pure)
Open Access
File
Genetic Predisposition to Disease
DNA Repair
Alleles
DNA Glycosylases
X-Rays
5 Citations (Scopus)
p53 Genes
Genetic Predisposition to Disease
Pancreatitis
Single Nucleotide Polymorphism
Oxidative Stress
3 Citations (Scopus)
13 Downloads (Pure)

Prevalence of the Janus kinase 2 V617F mutation in Philadelphia‑negative myeloproliferative neoplasms in a Portuguese population

Azevedo, A. P., Silva, S., Reichert, A., Lima, F., Júnior, E. & Rueff, J., Oct 2017, In : Biomedical Reports. 7, 4, p. 370-376 7 p.

Research output: Contribution to journalArticle

Open Access
File
Janus Kinase 2
Essential Thrombocythemia
Polycythemia Vera
Mutation
Primary Myelofibrosis
2016
2 Citations (Scopus)
Cytochrome P-450 CYP1A2
Cytochrome P-450 Enzyme System
2-amino-3-methylimidazo(4,5-f)quinoline
Mutagens
NADPH-Ferrihemoprotein Reductase
3 Citations (Scopus)

Glycidamide genotoxicity modulated by Caspases genes polymorphisms

de Lima, J. P., Silva, S. N., Rueff, J. & Pingarilho, M., 1 Aug 2016, In : Toxicology In Vitro. 34, p. 123-127 5 p.

Research output: Contribution to journalArticle

Caspases
Polymorphism
Genes
DNA Damage
Sister Chromatid Exchange
1 Citation (Scopus)
Human Genome
Viruses
Genes
HIV
Virus Integration
14 Citations (Scopus)

MicroRNAs and Cancer Drug Resistance

Gomes, B. C., Rueff, J. & Rodrigues, A. S., 2016, In : Methods In Molecular Biology (Clifton, N.J.). 1395, p. 137-62 26 p.

Research output: Contribution to journalArticle

MicroRNAs
Drug Resistance
Small Untranslated RNA
Neoplasms
Epithelial-Mesenchymal Transition

Preface

Rueff, J. & Rodrigues, AS., 2016, In : Methods In Molecular Biology (Clifton, N.J.). 1395, p. v-vii

Research output: Contribution to journalArticle

10 Citations (Scopus)

Prognostic value of microRNA-203a expression in breast cancer

Gomes, B. C., Martins, M., Lopes, P., Morujão, I., Oliveira, M., Araújo, A., Rueff, J. & Rodrigues, AS., 1 Sep 2016, In : Oncology Reports. 36, 3, p. 1748-1756 9 p.

Research output: Contribution to journalArticle

MicroRNAs
Breast Neoplasms
Neoplasms
Lobular Carcinoma
Carcinoma, Intraductal, Noninfiltrating
2 Citations (Scopus)
Metabolites
Cytochrome P-450 Enzyme System
DNA Damage
Throughput
Assays
2014
4 Citations (Scopus)
Nevirapine
Metabolites
Liver
Skin
Mutagenicity Tests
13 Citations (Scopus)
Myristica fragrans
K562 Cells
DNA Damage
Leukemia
Down-Regulation
2013
16 Citations (Scopus)

Functional characterization of eight human CYP1A2 variants: The role of cytochrome b5

Palma, B. B., Silva E Sousa, M., Urban, P., Rueff, J. & Kranendonk, M., 1 Feb 2013, In : Pharmacogenetics And Genomics. 23, 2, p. 41-52 12 p.

Research output: Contribution to journalArticle

Cytochromes b5
Cytochrome P-450 CYP1A2
Cytochrome P-450 Enzyme System
Oxidoreductases
NADPH-Ferrihemoprotein Reductase
10 Citations (Scopus)
Sister Chromatid Exchange
Acrylamide
DNA Repair
Lymphocytes
Genes
24 Citations (Scopus)
RNA Stability
Leukemia, Myelogenous, Chronic, BCR-ABL Positive
Pharmaceutical Preparations
Genes
Therapeutics
12 Citations (Scopus)

Mechanistic insights into the cytotoxicity and genotoxicity induced by glycidamide in human mammary cells

Gaspar, J. & Rueff, J., 2013, In : Mutagenesis. 28, 6, p. 721-729 9 p.

Research output: Contribution to journalArticle

Cytotoxicity
Breast
Acrylamide
Breast Neoplasms
Industrial chemicals
1 Citation (Scopus)

New neo-Clerodanes from Tinnea antiscorbutica Welv.

Gaspar, J., Martins, C. & Rueff, J., 2013, In : Journal Of The Brazilian Chemical Society. 24, 12, p. 1950-1956 7 p.

Research output: Contribution to journalArticle

Clerodane Diterpenes
Methanol
Cells
pinocembrin

Predominance of constitutional chromosomal rearrangements in human chromosomal fragile sites

Sequeira, I. J. D. S., Mexia, J. T. P. N., Santiago, J., Mamede, R., Silva, E., Santos, J., Faria, D., Rueff, J. & Brás, A., 1 Jan 2013, In : Open Journal of Genetics. 3, NA, p. 8-13

Research output: Contribution to journalArticle

Open Access
File
13 Citations (Scopus)
Thyroid Neoplasms
DNA Repair
Alleles
Single Nucleotide Polymorphism
Genotype
2012
19 Citations (Scopus)

Altered Human CYP3A4 Activity Caused by Antley-Bixler Syndrome-Related Variants of NADPH-Cytochrome P450 Oxidoreductase Measured in a Robust In Vitro System

Moutinho, D., Marohnic, C. C., Panda, S. P., Rueff, J., Masters, B. S. S. S. S. & Kranendonk, M., Apr 2012, In : Drug Metabolism And Disposition. 40, 4, p. 754-760 7 p.

Research output: Contribution to journalArticle

Antley-Bixler Syndrome Phenotype
Cytochrome P-450 CYP3A
NADPH-Ferrihemoprotein Reductase
Human Activities
Cytochrome P-450 Enzyme System
6 Citations (Scopus)
oxaliplatin
Oxidation-Reduction
Toxicity
Copper
Breast
14 Citations (Scopus)
5 Citations (Scopus)

DNA damage response in imatinib resistant chronic myeloid leukemia K562 cells.

Dinis, J., Silva, V., Gromicho, M., Martins, C., Laires, A., Tavares, P., Rendeiro, P., Torres, F., Rueff, J. & Rodrigues, AS., 2012, In : Leukemia & Lymphoma. 53, 10, p. 2004-14 11 p.

Research output: Contribution to journalArticle

K562 Cells
Leukemia, Myelogenous, Chronic, BCR-ABL Positive
DNA Damage
DNA Repair
Protein-Tyrosine Kinases
15 Citations (Scopus)

Estragole: A weak direct-acting food-borne genotoxin and potential carcinogen

Martins, C., Cação, R., Cole, K. J., Phillips, D. H., Laires, A., Rueff, J. & Rodrigues, A. S., 2012, In : Mutation Research-Genetic Toxicology And Environmental Mutagenesis. 747, 1, p. 86-92 7 p.

Research output: Contribution to journalArticle

Mutagens
Carcinogens
Comet Assay
Food
DNA Adducts
31 Citations (Scopus)

Genomics and Cancer Drug Resistance

Rodrigues, A. S., Dinis, J., Gromicho, M., Martins, C., Laires, A. & Rueff, J., 1 Jan 2012, In : Current Pharmaceutical Biotechnology. 13, 5, p. 651-673

Research output: Contribution to journalArticle

31 Citations (Scopus)
9 Downloads (Pure)

Polymorphisms in base excision repair genes and thyroid cancer risk

Silva, S. N., Azevedo, A. P. D. S., Rueff, J. & Gaspar, J. F., 2012, In : Oncology Reports. 28, 5, p. 1859-1868

Research output: Contribution to journalArticle

Open Access
File
Thyroid Neoplasms
DNA Repair
Genes
Iodine
Sample Size
2 Citations (Scopus)
15 Downloads (Pure)

SNPs/Pools: A methodology for the identification of relevant SNPs in breast cancer epidemiology

Silva, S. N., Guerreiro, D., Gomes, M., Azevedo, A. P., Castro, G. B., Rueff, J. & Gaspar, J. F., Feb 2012, In : Oncology Reports. 27, 2, p. 511-516 6 p.

Research output: Contribution to journalArticle

Open Access
File
Single Nucleotide Polymorphism
Epidemiology
Breast Neoplasms
DNA
Population
3 Citations (Scopus)

Three New Labdanes Isolated from Eragrostis viscosa

Gaspar, J. F., Martins, C. & Rueff, J., Oct 2012, In : Journal Of The Brazilian Chemical Society. 23, 10, p. 1940-1950 11 p.

Research output: Contribution to journalArticle

Open Access
File
Diterpenes
Assays
Methylene Chloride
Peroxides
Toluene
2011
42 Citations (Scopus)
18 Citations (Scopus)

Effect of kidney disease on glucose handling (including genetic defects)

Calado, J., Santer, R. & Rueff, J., 1 Jan 2011, In : Kidney International. 79, NA, p. S7S13

Research output: Contribution to journalArticle

Kidney Diseases
Renal Glycosuria
Glucose
5-chloro-3-tert-butyl-2'-chloro-4'-nitrosalicylanilide
ethyl-2-methylthio-4-methyl-5-pyrimidine carboxylate
27 Citations (Scopus)
Eugenol
eugenol
flavorings
Assays
foods
23 Citations (Scopus)
Glutathione Transferase
Doxorubicin
Genotype
Lymphocytes
Micronucleus Tests
2 Citations (Scopus)
2010
8 Citations (Scopus)

8,15-Epoxylabdane and norlabdane diterpenoids from Eragrostis viscosa

Gaspar, J. F. D. R., Martins, C. M. D. S. & Rueff, J., 1 Jan 2010, In : Phytochemistry. 71, 7, p. 798-803

Research output: Contribution to journalArticle

6 Citations (Scopus)

Alkylating Potential of Oxetanes

Gomez-Bombarelli, R., Palma, B. B., Martins, C., Kranendonk, M., Rodrigues, A. S., Calle, E., Rueff, J. & Casado, J., Jul 2010, In : Chemical Research In Toxicology. 23, 7, p. 1275-1281 7 p.

Research output: Contribution to journalArticle

Alkylating Agents
Epoxy Compounds
Lactones
Assays
Antimitotic Agents
17 Citations (Scopus)

Cytogenetic and DNA damage on workers exposed to styrene

Gaspar, J. F. D. R., Silva, S. N. & Rueff, J., 1 Jan 2010, In : Mutagenesis. 25, 6, p. 617-621

Research output: Contribution to journalArticle

20 Citations (Scopus)

Functional characterization of eight human cytochrome P450 1A2 gene variants by recombinant protein expression

Palma, B. B., Sousa, M. S., Vosmeer, C. R., Lastdrager, J., Rueff, J., Vermeulen, N. P. E. & Kranendonk, M., Dec 2010, In : Pharmacogenomics Journal. 10, 6, p. 478-488 9 p.

Research output: Contribution to journalArticle

Cytochrome P-450 CYP1A2
Recombinant Proteins
Apoproteins
Genes
Carcinogens
39 Citations (Scopus)
9 Downloads (Pure)

Human Cytochrome P450 Oxidoreductase Deficiency Caused by the Y181D Mutation: Molecular Consequences and Rescue of Defect

Marohnic, C. C., Panda, S. P., McCammon, K. M., Rueff, J., Masters, B. S. S. & Kranendonk, M., 1 Jan 2010, In : Drug Metabolism And Disposition. 38, 2, p. 332-340

Research output: Contribution to journalArticle

Open Access
File