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Research Output at NOVA 1982 2019

2019
Microsomes
Salmonella
Toxicology
Mutation
Research
1 Downloads (Pure)
Open Access
File
MicroRNAs
Drug Resistance
Neoplasms
Small Untranslated RNA
3' Untranslated Regions
Open Access
File
MicroRNAs
Drug Resistance
Doxorubicin
Breast Neoplasms
Real-Time Polymerase Chain Reaction
1 Citation (Scopus)
Philadelphia Chromosome
Genetic Predisposition to Disease
Caspases
Population
Genes

Thyroid cancer: The quest for genetic susceptibility involving dna repair genes

Santos, L. S., Gomes, B. C., Bastos, H. N., Gil, O. M., Azevedo, A. P., Ferreira, T. C., Limbert, E., Silva, S. N. & Rueff, J., 1 Aug 2019, In : Genes. 10, 8, 586.

Research output: Contribution to journalArticle

Genetic Predisposition to Disease
Thyroid Neoplasms
Single Nucleotide Polymorphism
DNA Repair
Genes
5 Citations (Scopus)
7 Downloads (Pure)

Down syndrome and microRNAs

Brás, A., Rodrigues, A. S., Gomes, B. & Rueff, J., Jan 2018, In : Biomedical Reports. 8, 1, p. 11-16 6 p.

Research output: Contribution to journalReview article

Open Access
File
Down Syndrome
MicroRNAs
Chromosomes
Pathology
Genes
1 Citation (Scopus)
Critical Pathways
Hydroxyurea
Caspases
DNA Repair
Polymorphism
2 Citations (Scopus)
alternative medicine
herbal medicines
flavorings
Risk assessment
functional foods

Handbook of Foodborne Diseases

Martins, C. M. D. S., Rueff, J. & Rodrigues, A. S., Sep 2018, Handbook of Foodborne Diseases. Liu, D. (ed.). CRC Press

Research output: Chapter in Book/Report/Conference proceedingChapter

Human cytochrome P450 expression in bacteria: Whole-cell high-throughput activity assay for CYP1A2, 2A6 and 3A4

Esteves, F., Campelo, D., Urban, P., Bozonnet, S., Lautier, T., Rueff, J., Truan, G. & Kranendonk, M., Dec 2018, In : Biochemical pharmacology. 158, p. 134-140 7 p.

Research output: Contribution to journalArticle

Cytochrome P-450 CYP1A2
Cytochromes
Cytochrome P-450 Enzyme System
Assays
Bacteria
1 Citation (Scopus)
4 Downloads (Pure)

Mismatch repair single nucleotide polymorphisms and thyroid cancer susceptibility

Santos, L. S., Silva, S. N., Gil, O. M., Ferreira, T. C., Limbert, E. & Rueff, J., May 2018, In : Oncology Letters. 15, 5, p. 6715-6726 12 p.

Research output: Contribution to journalArticle

Open Access
File
DNA Mismatch Repair
Thyroid Neoplasms
Single Nucleotide Polymorphism
Genotype
Genetic Predisposition to Disease
4 Downloads (Pure)
Open Access
File
NADPH-Ferrihemoprotein Reductase
hinges
cytochromes
Hinges
Cytochrome P-450 Enzyme System
Proximal Kidney Tubule
Facilitative Glucose Transport Proteins
Accessories
Glucose
Kidney
2017
3 Citations (Scopus)
14 Downloads (Pure)
Open Access
File
Genetic Predisposition to Disease
DNA Repair
Alleles
DNA Glycosylases
X-Rays
5 Citations (Scopus)
p53 Genes
Genetic Predisposition to Disease
Pancreatitis
Single Nucleotide Polymorphism
Oxidative Stress
3 Citations (Scopus)
13 Downloads (Pure)

Prevalence of the Janus kinase 2 V617F mutation in Philadelphia‑negative myeloproliferative neoplasms in a Portuguese population

Azevedo, A. P., Silva, S., Reichert, A., Lima, F., Júnior, E. & Rueff, J., Oct 2017, In : Biomedical Reports. 7, 4, p. 370-376 7 p.

Research output: Contribution to journalArticle

Open Access
File
Janus Kinase 2
Essential Thrombocythemia
Polycythemia Vera
Mutation
Primary Myelofibrosis
2016
28 Citations (Scopus)

Cancer drug resistance: A brief overview from a genetic viewpoint

Rueff, J. & Rodrigues, AS., 2016, Methods in Molecular Biology. Humana Press Inc, Vol. 1395. p. 1-18 18 p. (Methods in Molecular Biology; vol. 1395).

Research output: Chapter in Book/Report/Conference proceedingChapter

Drug Resistance
Neoplasms
Pharmaceutical Preparations
Treatment Failure
Tumor Microenvironment
2 Citations (Scopus)
Cytochrome P-450 CYP1A2
Cytochrome P-450 Enzyme System
2-amino-3-methylimidazo(4,5-f)quinoline
Mutagens
NADPH-Ferrihemoprotein Reductase

Dynamics of expression of drug transporters: Methods for Appraisal

Gromicho, M., Rueff, J. & Rodrigues, AS., 2016, Methods in Molecular Biology. Humana Press Inc, Vol. 1395. p. 75-85 11 p. (Methods in Molecular Biology; vol. 1395).

Research output: Chapter in Book/Report/Conference proceedingChapter

Cell Line
Leukemia, Myelogenous, Chronic, BCR-ABL Positive
Pharmaceutical Preparations
Protein-Tyrosine Kinases
Mutation
3 Citations (Scopus)

Glycidamide genotoxicity modulated by Caspases genes polymorphisms

de Lima, J. P., Silva, S. N., Rueff, J. & Pingarilho, M., 1 Aug 2016, In : Toxicology In Vitro. 34, p. 123-127 5 p.

Research output: Contribution to journalArticle

Caspases
Polymorphism
Genes
DNA Damage
Sister Chromatid Exchange
1 Citation (Scopus)
Human Genome
Viruses
Genes
HIV
Virus Integration
6 Citations (Scopus)

Methods for studying microrna expression and their targets in formalin-fixed, paraffin-embedded (FFpe) breast cancer tissues

Gomes, BC., Santos, B., Rueff, J. & Rodrigues, AS., 2016, Methods in Molecular Biology. Humana Press Inc, Vol. 1395. p. 189-205 17 p. (Methods in Molecular Biology; vol. 1395).

Research output: Chapter in Book/Report/Conference proceedingChapter

MicroRNAs
Paraffin
Formaldehyde
Breast Neoplasms
Drug Resistance
14 Citations (Scopus)

MicroRNAs and Cancer Drug Resistance

Gomes, B. C., Rueff, J. & Rodrigues, A. S., 2016, In : Methods In Molecular Biology (Clifton, N.J.). 1395, p. 137-62 26 p.

Research output: Contribution to journalArticle

MicroRNAs
Drug Resistance
Small Untranslated RNA
Neoplasms
Epithelial-Mesenchymal Transition

Preface

Rueff, J. & Rodrigues, AS., 2016, In : Methods In Molecular Biology (Clifton, N.J.). 1395, p. v-vii

Research output: Contribution to journalArticle

10 Citations (Scopus)

Prognostic value of microRNA-203a expression in breast cancer

Gomes, B. C., Martins, M., Lopes, P., Morujão, I., Oliveira, M., Araújo, A., Rueff, J. & Rodrigues, AS., 1 Sep 2016, In : Oncology Reports. 36, 3, p. 1748-1756 9 p.

Research output: Contribution to journalArticle

MicroRNAs
Breast Neoplasms
Neoplasms
Lobular Carcinoma
Carcinoma, Intraductal, Noninfiltrating
2 Citations (Scopus)
Metabolites
Cytochrome P-450 Enzyme System
DNA Damage
Throughput
Assays

The human chromosomal fragile sites more often involved in constitutional deletions and duplications - A genetic and statistical assessment

Gomes, D. P., Sequeira, I. J., Figueiredo, C., Rueff, J. & Brás, A., 6 Dec 2016, International Conference of Computational Methods in Sciences and Engineering 2016, ICCMSE 2016. American Institute of Physics Inc., Vol. 1790. 080003

Research output: Chapter in Book/Report/Conference proceedingConference contribution

deletion
genome
chromosomes
loci
regression analysis
2015
6 Citations (Scopus)

Epigenetic changes after prolonged exposure to alkenylbenzenes - An important signature of potential toxicological effects

Martins, C., Silva, I., Rueff, J. & Rodrigues, A., 16 Oct 2015, In : Toxicology Letters. 238, 2, p. S86-S86 1 p.

Research output: Contribution to journalMeeting Abstract

Erratum: Mechanistic insights into the cytotoxicity and genotoxicity induced by glycidamide in human mammary cells (Mutagenesis (2013) 28:6 (721-729))

Bandarra, S., Fernandes, A. S., Magro, I., Guerreiro, P. S., Pingarilho, M., Churchwell, M. I., Gil, O. M., Batinic-Haberle, I., Gonçalves, S., Rueff, J., Miranda, J. P., Marques, M. M., Beland, F. A., Castro, M., Gaspar, J. F. & Oliveira, N. G., 2014, In : Mutagenesis. 29, 1, 1 p.

Research output: Contribution to journalComment/debate

4 Citations (Scopus)
Nevirapine
Metabolites
Liver
Skin
Mutagenicity Tests
13 Citations (Scopus)
Myristica fragrans
K562 Cells
DNA Damage
Leukemia
Down-Regulation

DNA Repair and Resistance to Cancer Therapy

Rodrigues, A. S., Costa, B., Martins, C., Gromicho, M., G., N., Guerreiro, P. & Rueff, J., 22 May 2013, New Research Directions in DNA Repair. Chen, C. (ed.). InTech

Research output: Chapter in Book/Report/Conference proceedingChapter

16 Citations (Scopus)

Functional characterization of eight human CYP1A2 variants: The role of cytochrome b5

Palma, B. B., Silva E Sousa, M., Urban, P., Rueff, J. & Kranendonk, M., 1 Feb 2013, In : Pharmacogenetics And Genomics. 23, 2, p. 41-52 12 p.

Research output: Contribution to journalArticle

Cytochromes b5
Cytochrome P-450 CYP1A2
Cytochrome P-450 Enzyme System
Oxidoreductases
NADPH-Ferrihemoprotein Reductase
1 Downloads (Pure)

Genetic and statistical study of HIV integration in the human genome

Sequeira, I. J., Gonçalves, J., Moreira, E., Mexia, J. T., Rueff, J. & Brás, A., 19 Nov 2013, 11th International Conference of Numerical Analysis and Applied Mathematics 2013, ICNAAM 2013. Simos, T., Psihoyios, G. & Tsitouras, C. (eds.). American Institute of Physics Inc., p. 813-816 4 p. (AIP Conference Proceedings; vol. 1558).

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Open Access
File
human immunodeficiency virus
genome
analysis of variance
chromosomes
deoxyribonucleic acid
10 Citations (Scopus)
Sister Chromatid Exchange
Acrylamide
DNA Repair
Lymphocytes
Genes
24 Citations (Scopus)
RNA Stability
Leukemia, Myelogenous, Chronic, BCR-ABL Positive
Pharmaceutical Preparations
Genes
Therapeutics
12 Citations (Scopus)

Mechanistic insights into the cytotoxicity and genotoxicity induced by glycidamide in human mammary cells

Gaspar, J. & Rueff, J., 2013, In : Mutagenesis. 28, 6, p. 721-729 9 p.

Research output: Contribution to journalArticle

Cytotoxicity
Breast
Acrylamide
Breast Neoplasms
Industrial chemicals
1 Citation (Scopus)

New neo-Clerodanes from Tinnea antiscorbutica Welv.

Gaspar, J., Martins, C. & Rueff, J., 2013, In : Journal Of The Brazilian Chemical Society. 24, 12, p. 1950-1956 7 p.

Research output: Contribution to journalArticle

Clerodane Diterpenes
Methanol
Cells
pinocembrin

Predominance of constitutional chromosomal rearrangements in human chromosomal fragile sites

Sequeira, I. J. D. S., Mexia, J. T. P. N., Santiago, J., Mamede, R., Silva, E., Santos, J., Faria, D., Rueff, J. & Brás, A., 1 Jan 2013, In : Open Journal of Genetics. 3, NA, p. 8-13

Research output: Contribution to journalArticle

Open Access
File
13 Citations (Scopus)
Thyroid Neoplasms
DNA Repair
Alleles
Single Nucleotide Polymorphism
Genotype
2012
19 Citations (Scopus)

Altered Human CYP3A4 Activity Caused by Antley-Bixler Syndrome-Related Variants of NADPH-Cytochrome P450 Oxidoreductase Measured in a Robust In Vitro System

Moutinho, D., Marohnic, C. C., Panda, S. P., Rueff, J., Masters, B. S. S. S. S. & Kranendonk, M., Apr 2012, In : Drug Metabolism And Disposition. 40, 4, p. 754-760 7 p.

Research output: Contribution to journalArticle

Antley-Bixler Syndrome Phenotype
Cytochrome P-450 CYP3A
NADPH-Ferrihemoprotein Reductase
Human Activities
Cytochrome P-450 Enzyme System
6 Citations (Scopus)
oxaliplatin
Oxidation-Reduction
Toxicity
Copper
Breast
14 Citations (Scopus)
5 Citations (Scopus)

DNA damage response in imatinib resistant chronic myeloid leukemia K562 cells.

Dinis, J., Silva, V., Gromicho, M., Martins, C., Laires, A., Tavares, P., Rendeiro, P., Torres, F., Rueff, J. & Rodrigues, AS., 2012, In : Leukemia & Lymphoma. 53, 10, p. 2004-14 11 p.

Research output: Contribution to journalArticle

K562 Cells
Leukemia, Myelogenous, Chronic, BCR-ABL Positive
DNA Damage
DNA Repair
Protein-Tyrosine Kinases
15 Citations (Scopus)

Estragole: A weak direct-acting food-borne genotoxin and potential carcinogen

Martins, C., Cação, R., Cole, K. J., Phillips, D. H., Laires, A., Rueff, J. & Rodrigues, A. S., 2012, In : Mutation Research-Genetic Toxicology And Environmental Mutagenesis. 747, 1, p. 86-92 7 p.

Research output: Contribution to journalArticle

Mutagens
Carcinogens
Comet Assay
Food
DNA Adducts