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Personal profile

Research interests

I am interested in molecular and cellular mechanisms underlying bacterial virulence. I focus on intracellular bacterial pathogens that multiply within host cells in unique membrane-bound organelles (pathogen-containing vacuoles) and cause important human diseases. I aim to understand the function of individual bacterial proteins (effectors) injected into host cells by specialised secretion systems of Chlamydia, Legionella and Salmonella and how this may relate to the infections caused by these bacteria. The expectation is that this basic knowledge might help to develop new strategies to combat infectious diseases.

Keywords: Bacterial infections; virulence factors; Chlamydia; Salmonella; bacterial protein secretion

Education/Academic qualification

Biology, Doctorate, Instituto de Tecnologia Química e Biológica António Xavier (ITQB)

Applied Chemistry-Biotechnology, Bachelor, Faculdade de Ciências e Tecnologia (FCT)

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Chlamydia trachomatis Medicine & Life Sciences
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Bacillus subtilis Medicine & Life Sciences
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Proteins Medicine & Life Sciences
Vacuoles Medicine & Life Sciences
Operon Medicine & Life Sciences
Chlamydia Medicine & Life Sciences

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Research Output at NOVA 1997 2019

  • 447 Citations
  • 13 h-Index
  • 20 Article
  • 2 Review article
  • 1 Chapter
2 Citations (Scopus)

CteG is a Chlamydia trachomatis effector protein that associates with the Golgi complex of infected host cells

Pais, S. V., Key, C. E., Borges, V., Pereira, I. S., Gomes, J. P., Fisher, D. J. & Mota, L. J., 1 Dec 2019, In : Scientific Reports. 9, 1, 6133.

Research output: Contribution to journalArticle

Open Access
File
Chlamydia trachomatis
Golgi Apparatus
Proteins
Cell Membrane
Eye Infections
3 Citations (Scopus)
4 Downloads (Pure)

Ssav interacts with SsaL to control the translocon-to-effector switch in the salmonella SPI-2 type three secretion system

Yu, X. J., Grabe, G. J., Liu, M., Mota, L. J. & Holden, D. W., 1 Sep 2018, In : mBio. 9, 5, e01149-18.

Research output: Contribution to journalArticle

Open Access
File
Salmonella
Proteins
Genomic Islands
Vacuoles
Bacteria
2 Citations (Scopus)
Open Access
Chlamydia
Chlamydia trachomatis
Vacuoles
Membrane Proteins
Proteins

Effector translocation assay: Differential solubilization

Franco, I. S., Pais, S. V., Charro, N. & Mota, L. J., 1 Jan 2017, Methods in Molecular Biology. Humana Press Inc., Vol. 1615. p. 501-515 15 p. (Methods in Molecular Biology; vol. 1615).

Research output: Chapter in Book/Report/Conference proceedingChapter

Cell Membrane
Bacterial Proteins
Octoxynol
Immunoblotting
Detergents
6 Citations (Scopus)
24 Downloads (Pure)

The Chlamydia trachomatis type III secretion substrates CT142, CT143, and CT144 are secreted into the lumen of the inclusion

Cunha, M. D., Pais, S. V., Bugalhão, J. N. & Mota, L. J., 1 Jun 2017, In : PLoS ONE. 12, 6, e0178856.

Research output: Contribution to journalArticle

Open Access
File
Chlamydia trachomatis
secretion
Substrates
Microscopic examination
cells