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Research Output at NOVA 2015 2019

  • 203 Citations
  • 8 h-Index
  • 9 Article
  • 1 Review article
  • 1 Other contribution
2019
8 Citations (Scopus)
12 Downloads (Pure)

Extracellular aggregated alpha synuclein primarily triggers lysosomal dysfunction in neural cells prevented by trehalose

Hoffmann, A. C., Minakaki, G., Menges, S., Salvi, R., Savitskiy, S., Kazman, A., Vicente Miranda, H., Mielenz, D., Klucken, J., Winkler, J. & Xiang, W., 24 Jan 2019, In : Scientific Reports. 9, 1, 544.

Research output: Contribution to journalArticle

Open Access
File
alpha-Synuclein
Trehalose
Lysosomes
Endosomes
Autophagy
2018
4 Citations (Scopus)

Alpha-Synuclein Glycation and the Action of Anti-Diabetic Agents in Parkinson's Disease

König, A., Vicente Miranda, H. & Outeiro, T. F., 18 Feb 2018, In : Journal of Parkinson's Disease. 8, 1, p. 33-43 11 p.

Research output: Contribution to journalReview article

alpha-Synuclein
Parkinson Disease
Advanced Glycosylation End Products
Proteins
Diabetes Complications
2017

Correction: The mechanism of sirtuin 2-mediated exacerbation of alpha-synuclein toxicity in models of Parkinson disease

de Oliveira, R. M., Vicente Miranda, H., Francelle, L., Pinho, R., Szegö, É. M., Martinho, R., Munari, F., Lázaro, D. F., Moniot, S., Guerreiro, P., Fonseca-Ornelas, L., Marijanovic, Z., Antas, P., Gerhardt, E., Enguita, F. J., Fauvet, B., Penque, D., Pais, T. F., Tong, Q., Becker, S. & 5 othersKügler, S., Lashuel, H. A., Steegborn, C., Zweckstetter, M. & Outeiro, T. F., Apr 2017

Research output: Other contribution

Sirtuin 2
alpha-Synuclein
Parkinson Disease
35 Citations (Scopus)

Glycation potentiates α-synuclein-associated neurodegeneration in synucleinopathies

Vicente Miranda, H., Szego, É. M., Oliveira, L. M. A., Breda, C., Darendelioglu, E., De Oliveira, R. M., Ferreira, D. G., Gomes, M. A., Rott, R., Oliveira, M., Munari, F., Enguita, F. J., Simões, T., Rodrigues, E. F., Heinrich, M., Martins, I. C., Zamolo, I., Riess, O., Cordeiro, C., Ponces-Freire, A. & 12 othersLashuel, H. A., Santos, N. C., Lopes, L. V., Xiang, W., Jovin, T. M., Penque, D., Engelender, S., Zweckstetter, M., Klucken, J., Giorgini, F., Quintas, A. & Outeiro, T. F., 1 May 2017, In : Brain. 140, 5, p. 1399-1419 21 p.

Research output: Contribution to journalArticle

Synucleins
Poisons
Drosophila
Post Translational Protein Processing
Synaptic Transmission
16 Citations (Scopus)
6 Downloads (Pure)

Posttranslational modifications of blood-derived alpha-synuclein as biochemical markers for Parkinson's disease

Miranda, H. V., Cássio, R., Correia-Guedes, L., Gomes, M. A., Chegão, A., Miranda, E., Soares, T., Coelho, M., Rosa, M. M., Ferreira, J. J. & Outeiro, T. F., 2017, In : Scientific Reports. 7, 1, p. Online 11 p., 13713.

Research output: Contribution to journalArticle

Open Access
File
alpha-Synuclein
Post Translational Protein Processing
Parkinson Disease
Biomarkers
Disease Progression
1 Citation (Scopus)

Synthesis and Biological Evaluation of Novel 2-Aryl Benzimidazoles as Chemotherapeutic Agents

Morais, G. R., Palma, E., Marques, F., Gano, L., Oliveira, M. C., Abrunhosa, A., Miranda, H. V., Outeiro, T. F., Santos, I. & Paulo, A., Jan 2017, In : Journal Of Heterocyclic Chemistry. 54, 1, p. 255-267

Research output: Contribution to journalArticle

Benzimidazoles
Brain
Benzothiazoles
Derivatives
Chemotherapy
34 Citations (Scopus)
3 Downloads (Pure)

The mechanism of sirtuin 2–mediated exacerbation of alpha-synuclein toxicity in models of Parkinson disease

de Oliveira, R. M., Vicente Miranda, H., Francelle, L., Pinho, R., Szegö, É. M., Martinho, R., Munari, F., Lázaro, D. F., Moniot, S., Guerreiro, P., Fonseca, L., Marijanovic, Z., Antas, P., Gerhardt, E., Enguita, F. J., Fauvet, B., Penque, D., Pais, T. F., Tong, Q., Becker, S. & 5 othersKügler, S., Lashuel, H. A., Steegborn, C., Zweckstetter, M. & Outeiro, T. F., Mar 2017, In : PLoS Biology. 15, 3, p. Online 27 p.

Research output: Contribution to journalArticle

Open Access
File
Synucleins
Sirtuin 2
alpha-Synuclein
Parkinson disease
acetylation
53 Citations (Scopus)

α-synuclein interacts with PrP C to induce cognitive impairment through mGluR5 and NMDAR2B

Ferreira, D. G., Temido-Ferreira, M., Miranda, H. V., Batalha, V. L., Coelho, J. E., Szegö, É. M., Marques-Morgado, I., Vaz, S. H., Rhee, J. S., Schmitz, M., Zerr, I., Lopes, L. V. & Outeiro, T. F., 1 Jan 2017, In : Nature Neuroscience. 20, 11, p. 1569-1579 11 p.

Research output: Contribution to journalArticle

Synucleins
Metabotropic Glutamate 5 Receptor
N-Methyl-D-Aspartate Receptors
Phosphorylation
Lewy Bodies
2016
32 Citations (Scopus)

Glycation in Parkinson's disease and Alzheimer's disease

Vicente Miranda, H., El-Agnaf, O. M. A. & Outeiro, T. F., Jun 2016, In : Movement disorders : official journal of the Movement Disorder Society. 31, 6, p. 782-90 9 p.

Research output: Contribution to journalArticle

Parkinson Disease
Alzheimer Disease
Synucleins
Lewy Bodies
Proteins
11 Citations (Scopus)
4 Downloads (Pure)

Glycation potentiates neurodegeneration in models of Huntington's disease

Miranda, H. V., Gomes, M. A., Branco-Santos, J., Breda, C., Lazaro, D. F., Lopes, L. V., Herrera, F., Giorgini, F. & Outeiro, T. F., 18 Nov 2016, In : Scientific Reports. 6

Research output: Contribution to journalArticle

Open Access
File
Huntington Disease
Exons
Protein Folding
Autophagy
Post Translational Protein Processing
2015
9 Citations (Scopus)

Isostructural Re(I)/Tc-99m(I) tricarbonyl complexes for cancer theranostics

Nunes, P., Morais, G. R., Palma, E., Silva, F., Oliveira, M. C., Ferreira, V. F. C., Mendes, F., Gano, L., Vicente Miranda, H., Outeiro, T. F., Santos, I. & Paulo, A., 2015, In : Organic & Biomolecular Chemistry. 13, 18, p. 5182-5194 13 p.

Research output: Contribution to journalArticle