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Personal profile

Research interests

Overall, our lab is interested in determining how immune receptor signaling is able to convey distinct immune responses that protect us against disparate aggressions (fungus, virus, bacteria, cancer, etc.).
Our current research is comprised of three interconnected axis:
1- To establish how signaling architecture regulates immune responses;
2- To determine how alterations in signaling lead to auto-immunity;
3- To decipher how pathogens (HIV-1) exploit the immune signaling to their own advantage.

Education/Academic qualification

Biomedicine, Doctorate, The Rockefeller University

4 Nov 200427 Nov 2006

Pharmaceutical Sciences, Universidade de Coimbra

5 Nov 199529 Jun 2001

Fingerprint Dive into the research topics where Helena Isabel Martins Soares is active. These topic labels come from the works of this person. Together they form a unique fingerprint.

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Research Output at NOVA 2014 2018

  • 1259 Citations
  • 8 h-Index
  • 1 Meeting Abstract
  • 1 Article
  • 1 Short survey

MHC class I stability is modulated by cell surface sialylation in human dendritic cells

Ferro, T., Crespo, H., Silva, Z., Goncalves, M., Soares, H., Ferreira, J. A., Springer, S. & Videira, P., May 2018, In : European Journal of Immunology. 48, Suppl.1, p. 46-47

Research output: Contribution to journalMeeting Abstract

8 Citations (Scopus)

HIV-1 Nef Impairs the Formation of Calcium Membrane Territories Controlling the Signaling Nanoarchitecture at the Immunological Synapse.

Silva, J. G., Martins, N., Henriques, R. & Soares, H., 19 Oct 2016, In : Journal of Immunology . 11, 197, p. 042-4052 10 p., 10.4049/jimmunol.1601132.

Research output: Contribution to journalArticle

Immunological Synapses
nef Gene Products
4 Citations (Scopus)
7 Downloads (Pure)

HIV-1 intersection with CD4 T cell vesicle exocytosis: intercellular communication goes viral

Soares, H., Sep 2014, In : Frontiers in Immunology. 5, 454, p. Online

Research output: Contribution to journalShort survey

Open Access
Immunological Synapses
T-Cell Antigen Receptor


Bridging Innate and Adaptive Immunity through JAK signalling

Helena Isabel Martins Soares (Recipient), 30 Jun 2017

Prize: Fellowship awarded competitively

Development of Novel AZT Derivatives Based on Triazoles

Helena Isabel Martins Soares (Recipient), 30 Sep 2017

Prize: Fellowship awarded competitively

HIV-1 Replication in Follicular Sanctiaries

Helena Isabel Martins Soares (Recipient), 6 Apr 2017

Prize: Fellowship awarded competitively