• 385 Citations
  • 10 h-Index
20132019
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Research Output at NOVA 2013 2019

  • 385 Citations
  • 10 h-Index
  • 14 Article
  • 2 Chapter
2019
2 Citations (Scopus)

Identification of a secondary binding site in human macrophage galactose-type lectin by microarray studies: Implications for the molecular recognition of its ligands

Marcelo, F., Supekar, N., Corzana, F., Van Der Horst, J. C., Vuist, I. M., Live, D., Boons, G. J. P. H., Smith, D. F. & Van Vliet, S. J., 1 Jan 2019, In : Journal of Biological Chemistry. 294, 4, p. 1300-1311 12 p.

Research output: Contribution to journalArticle

Molecular recognition
Macrophages
Microarrays
Galactose
Lectins
2018
1 Citation (Scopus)

Acetylcholinesterase Choline-Based Ionic Liquid Inhibitors: In Vitro and in Silico Molecular Docking Studies

Siopa, F., Frade, R. F. M., Diniz, A., Andrade, J. M., Nicolai, M., Meirinhos, A., Lucas, S. D., Marcelo, F., Afonso, C. A. M. & Rijo, P., 12 Dec 2018, In : ACS Omega. 3, 12, p. 17145-17154 10 p.

Research output: Contribution to journalArticle

Open Access
Ionic Liquids
Acetylcholinesterase
Choline
Ionic liquids
Galantamine

Glycosyltransferase inhibitors: a promising strategy to pave a path from laboratory to therapy

Videira, P. A., Marcelo, F. M. B. M. & Grewal, R. K., 2018, Carbohydrate Chemistry: Chemical and Biological Approaches. Rauter, A. P., Lindhorst, T. & Queneau, Y. (eds.). Royal Society Chemistry, Vol. 43. p. 135-158

Research output: Chapter in Book/Report/Conference proceedingChapter

Glycosyltransferases
Glycoside Hydrolases
Therapeutics
Glycosylation
Substrate Specificity
3 Citations (Scopus)

Molecular Recognition of a Thomsen–Friedenreich Antigen Mimetic Targeting Human Galectin-3

Santarsia, S., Grosso, A. S., Trovão, F., Jiménez-Barbero, J., Carvalho, A. L., Nativi, C. & Marcelo, F., 8 Oct 2018, In : Chemmedchem. 13, 19, p. 2030-2036 7 p.

Research output: Contribution to journalArticle

Galectin 3
Molecular recognition
Antigens
Neoplasm Metastasis
Neoplasms
6 Citations (Scopus)

Structural Analysis of a GalNAc-T2 Mutant Reveals an Induced-Fit Catalytic Mechanism for GalNAc-Ts

de las Rivas, M., Coelho, H., Diniz, A., Lira-Navarrete, E., Compañón, I., Jiménez-Barbero, J., Schjoldager, K. T., Bennett, E. P., Vakhrushev, S. Y., Clausen, H., Corzana, F., Marcelo, F. & Hurtado-Guerrero, R., 12 Jun 2018, In : Chemistry - A European Journal. 24, 33, p. 8382-8392 11 p.

Research output: Contribution to journalArticle

Uridine Diphosphate
Structural analysis
Enzymes
Glycosylation
Proteins
8 Citations (Scopus)

Structural and Mechanistic Insights into the Catalytic-Domain-Mediated Short-Range Glycosylation Preferences of GalNAc-T4

De Las Rivas, M., Paul Daniel, E. J., Coelho, H., Lira-Navarrete, E., Raich, L., Compañón, I., Diniz, A., Lagartera, L., Jiménez-Barbero, J., Clausen, H., Rovira, C., Marcelo, F., Corzana, F., Gerken, T. A. & Hurtado-Guerrero, R., 26 Sep 2018, In : ACS Central Science. 4, 9, p. 1274-1290 17 p.

Research output: Contribution to journalArticle

Glycosylation
Lectins
Glycopeptides
Binding sites
Binding Sites

Structural elucidation of macromolecules

Romão, M. J., Santos-Silva, T. S., Carvalho, A. L., Cabrita, E. J. & Marcelo, F. M. B. M., 2018, Essential Techniques for Medical and Life Scientists : A Guide to Contemporary Methods and Current Applications With the Protocols. Bentham Science Publishers Ltd., Vol. Pt.1. p. 30-91 61 p.

Research output: Chapter in Book/Report/Conference proceedingChapter

Macromolecules
Ligands
X ray crystallography
X ray scattering
Nucleic Acids
2017
10 Citations (Scopus)

Protein–Glycan Quinary Interactions in Crowding Environment Unveiled by NMR Spectroscopy

Diniz, A., Dias, J. S., Jiménez-Barbero, J., Marcelo, F. & Cabrita, E. J., 21 Sep 2017, In : Chemistry - A European Journal. 23, 53, p. 13213-13220 8 p.

Research output: Contribution to journalArticle

Galectin 3
Nuclear magnetic resonance spectroscopy
Lactose
Ficoll
Glycoproteins
1 Citation (Scopus)

Role of the sugar moiety on the opioid receptor binding and conformation of a series of enkephalin neoglycopeptides

Rosa, M., Gonzalez-Nunez, V., Barreto-Valer, K., Marcelo, F., Sánchez-Sánchez, J., Calle, L. P., Arévalo, J. C., Rodríguez, R. E., Jiménez-Barbero, J., Arsequell, G. & Valencia, G., 1 Jan 2017, In : Bioorganic and Medicinal Chemistry. 25, 7, p. 2260-2265 6 p.

Research output: Contribution to journalArticle

Glycopeptides
Enkephalins
Opioid Receptors
Sugars
Conformations
12 Citations (Scopus)

The interdomain flexible linker of the polypeptide GalNAc transferases dictates their long-range glycosylation preferences

Rivas, M. D. L., Lira-Navarrete, E., Daniel, E. J. P., Companõn, I., Coelho, H., Diniz, A., Jiménez-Barbero, J., Peregrina, J. M., Clausen, H., Corzana, F., Marcelo, F., Jiménez-Osés, G., Gerken, T. A. & Hurtado-Guerrero, R., 1 Dec 2017, In : Nature Communications. 8, 1, 1959.

Research output: Contribution to journalArticle

Glycosylation
polypeptides
Peptides
Lectins
molecular dynamics
2015
1 Citation (Scopus)

Influence of polar side chains modifications on the dual enkephalinase inhibitory activity and conformation of human opiorphin, a pain perception related peptide

Rosa, M., Marcelo, F., Calle, L. P., Rougeot, C., Jiménez-Barbero, J., Arsequell, G. & Valencia, G., 15 Nov 2015, In : Bioorganic and Medicinal Chemistry Letters. 25, 22, p. 5190-5193 4 p.

Research output: Contribution to journalArticle

glutaminyl-arginyl-phenylalanyl-seryl-arginine
Neprilysin
Pain Perception
Human Activities
Conformations
22 Citations (Scopus)

The Quest for Anticancer Vaccines: Deciphering the Fine-Epitope Specificity of Cancer-Related Monoclonal Antibodies by Combining Microarray Screening and Saturation Transfer Difference NMR

Coelho, H., Matsushita, T., Artigas, G., Hinou, H., Javier Canada, F., Lo-Man, R., Leclerc, C., Cabrita, E. J., Jimenez-Barbero, J., Nishimura, S-I., Garcia-Martin, F. & Marcelo, F. M. B. M., 7 Oct 2015, In : Journal of the American Chemical Society. 137, 39, p. 12438-12441 4 p.

Research output: Contribution to journalArticle

2014
7 Citations (Scopus)

Cooperative Hydrogen Bonding in Glyco-Oligoamides: DNA Minor Groove Binders in Aqueous Media

Teresa Blazquez-Sanchez, M., Marcelo, F., Carmen Fernandez-Alonso, M., Poveda, A., Jimenez-Barbero, J. & Vicent, C., 22 Dec 2014, In : Chemistry-A European Journal. 20, 52, p. 17640-17652 13 p.

Research output: Contribution to journalArticle

27 Citations (Scopus)

Delineating binding modes of Gal/GalNAc and structural elements of the molecular recognition of tumor-associated mucin glycopeptides by the human macrophage galactose-type lectin

Marcelo, F., Garcia-Martin, F., Matsushita, T., Sardinha, J., Coelho, H., Oude-Vrielink, A., Koller, C., André, S., Cabrita, E. J., Gabius, H. J., Nishimura, S. I., Jiménez-Barbero, J. & Cañada, F. J., 12 Jan 2014, In : Chemistry - A European Journal. 20, 49, p. 16147-16155 9 p.

Research output: Contribution to journalArticle

Molecular recognition
Glycopeptides
Macrophages
Mucins
Lectins
21 Citations (Scopus)

Exploiting the Therapeutic Potential of 8-beta-D-Glucopyranosylgenistein: Synthesis, Antidiabetic Activity, and Molecular Interaction with Islet Amyloid Polypeptide and Amyloid beta-Peptide (1-42)

Jesus, A. R., Dias, C., Matos, A. M., de Almeida, R. F. M., Viana, A. S., Marcelo, F. M. B. M., Ribeiro, R. T., Macedo, M. P., Airoldi, C., Nicotra, F., Martins, A., Cabrita, E. J., Jimenez-Barbere, J. & Rauter, A. P., 27 Nov 2014, In : Journal Of Medicinal Chemistry. 57, 22, p. 9463-9472 10 p.

Research output: Contribution to journalArticle

Islet Amyloid Polypeptide
Hypoglycemic Agents
Amyloid
Genista
Atomic Force Microscopy
2013
75 Citations (Scopus)

NHC-Capped Cyclodextrins (ICyDs): Insulated Metal Complexes, Commutable Multicoordination Sphere, and Cavity-Dependent Catalysis

Guitet, M., Zhang, P., Marcelo, F. M. B. M., Tugny, C., Jimenez-Barbere, J., Buriez, O., Amatore, C., Mouriès-Mansuy, V., Goddard, J-P., Fensterbank, L., Zhang, Y., Roland, S., Ménand, M. & Sollogoub, M., 3 Jun 2013, In : Angewandte Chemie-International Edition. 52, 28, p. 7213-7218

Research output: Contribution to journalArticle

Open Access