• 932 Citations
  • 17 h-Index
20122020

Research output per year

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Research Output at NOVA

  • 932 Citations
  • 17 h-Index
  • 24 Article
  • 2 Chapter
2020

Molecular basis for fibroblast growth factor 23 O-glycosylation by GalNAc-T3

de las Rivas, M., Paul Daniel, E. J., Narimatsu, Y., Compañón, I., Kato, K., Hermosilla, P., Thureau, A., Ceballos-Laita, L., Coelho, H., Bernadó, P., Marcelo, F., Hansen, L., Maeda, R., Lostao, A., Corzana, F., Clausen, H., Gerken, T. A. & Hurtado-Guerrero, R., 1 Jan 2020, (Accepted/In press) In : Nature Chemical Biology.

Research output: Contribution to journalArticle

3 Citations (Scopus)

SLMP53-1 interacts with wild-type and mutant p53 DNA-binding domain and reactivates multiple hotspot mutations

Gomes, A. S., Ramos, H., Gomes, S., Loureiro, J. B., Soares, J., Barcherini, V., Monti, P., Fronza, G., Oliveira, C., Domingues, L., Bastos, M., Dourado, D. F. A. R., Carvalho, A. L., Romão, M. J., Pinheiro, B., Marcelo, F., Carvalho, A., Santos, M. M. M. & Saraiva, L., 1 Jan 2020, In : Biochimica et Biophysica Acta - General Subjects. 1864, 1, 129440.

Research output: Contribution to journalArticle

Open Access
3 Citations (Scopus)
2019

Identification of a secondary binding site in human macrophage galactose-type lectin by microarray studies: Implications for the molecular recognition of its ligands

Marcelo, F., Supekar, N., Corzana, F., Van Der Horst, J. C., Vuist, I. M., Live, D., Boons, G. J. P. H., Smith, D. F. & Van Vliet, S. J., 1 Jan 2019, In : Journal of Biological Chemistry. 294, 4, p. 1300-1311 12 p.

Research output: Contribution to journalArticle

9 Citations (Scopus)

The Plasticity of the Carbohydrate Recognition Domain Dictates the Exquisite Mechanism of Binding of Human Macrophage Galactose-Type Lectin

Diniz, A., Coelho, H., Dias, J. S., van Vliet, S. J., Jiménez-Barbero, J., Corzana, F., Cabrita, E. J. & Marcelo, F., 4 Nov 2019, In : Chemistry - A European Journal. 25, 61, p. 13945-13955

Research output: Contribution to journalArticle

8 Citations (Scopus)
2018

Acetylcholinesterase Choline-Based Ionic Liquid Inhibitors: In Vitro and in Silico Molecular Docking Studies

Siopa, F., Frade, R. F. M., Diniz, A., Andrade, J. M., Nicolai, M., Meirinhos, A., Lucas, S. D., Marcelo, F., Afonso, C. A. M. & Rijo, P., 12 Dec 2018, In : ACS Omega. 3, 12, p. 17145-17154 10 p.

Research output: Contribution to journalArticle

Open Access
1 Citation (Scopus)

Glycosyltransferase inhibitors: A promising strategy to pave a path from laboratory to therapy

Videira, P. A., Marcelo, F. & Grewal, R. K., 2018, Carbohydrate Chemistry: Chemical and Biological Approaches. Lindhorst, T. K., Queneau, Y. & Rauter, A. P. (eds.). Royal Society of Chemistry, p. 135-158 24 p. (Carbohydrate Chemistry; vol. 43).

Research output: Chapter in Book/Report/Conference proceedingChapter

4 Citations (Scopus)

Molecular Recognition of a Thomsen–Friedenreich Antigen Mimetic Targeting Human Galectin-3

Santarsia, S., Grosso, A. S., Trovão, F., Jiménez-Barbero, J., Carvalho, A. L., Nativi, C. & Marcelo, F., 8 Oct 2018, In : Chemmedchem. 13, 19, p. 2030-2036 7 p.

Research output: Contribution to journalArticle

5 Citations (Scopus)

Structural Analysis of a GalNAc-T2 Mutant Reveals an Induced-Fit Catalytic Mechanism for GalNAc-Ts

de las Rivas, M., Coelho, H., Diniz, A., Lira-Navarrete, E., Compañón, I., Jiménez-Barbero, J., Schjoldager, K. T., Bennett, E. P., Vakhrushev, S. Y., Clausen, H., Corzana, F., Marcelo, F. & Hurtado-Guerrero, R., 12 Jun 2018, In : Chemistry - A European Journal. 24, 33, p. 8382-8392 11 p.

Research output: Contribution to journalArticle

7 Citations (Scopus)

Structural and Mechanistic Insights into the Catalytic-Domain-Mediated Short-Range Glycosylation Preferences of GalNAc-T4

De Las Rivas, M., Paul Daniel, E. J., Coelho, H., Lira-Navarrete, E., Raich, L., Compañón, I., Diniz, A., Lagartera, L., Jiménez-Barbero, J., Clausen, H., Rovira, C., Marcelo, F., Corzana, F., Gerken, T. A. & Hurtado-Guerrero, R., 26 Sep 2018, In : ACS Central Science. 4, 9, p. 1274-1290 17 p.

Research output: Contribution to journalArticle

11 Citations (Scopus)

Structural elucidation of macromolecules

Romão, M. J., Santos-Silva, T. S., Carvalho, A. L., Cabrita, E. J. & Marcelo, F. M. B. M., 2018, Essential Techniques for Medical and Life Scientists : A Guide to Contemporary Methods and Current Applications With the Protocols. Bentham Science Publishers Ltd., Vol. Pt.1. p. 30-91 61 p.

Research output: Chapter in Book/Report/Conference proceedingChapter

2017

Protein–Glycan Quinary Interactions in Crowding Environment Unveiled by NMR Spectroscopy

Diniz, A., Dias, J. S., Jiménez-Barbero, J., Marcelo, F. & Cabrita, E. J., 21 Sep 2017, In : Chemistry - A European Journal. 23, 53, p. 13213-13220 8 p.

Research output: Contribution to journalArticle

10 Citations (Scopus)

Role of the sugar moiety on the opioid receptor binding and conformation of a series of enkephalin neoglycopeptides

Rosa, M., Gonzalez-Nunez, V., Barreto-Valer, K., Marcelo, F., Sánchez-Sánchez, J., Calle, L. P., Arévalo, J. C., Rodríguez, R. E., Jiménez-Barbero, J., Arsequell, G. & Valencia, G., 1 Jan 2017, In : Bioorganic and Medicinal Chemistry. 25, 7, p. 2260-2265 6 p.

Research output: Contribution to journalArticle

2 Citations (Scopus)

The interdomain flexible linker of the polypeptide GalNAc transferases dictates their long-range glycosylation preferences

Rivas, M. D. L., Lira-Navarrete, E., Daniel, E. J. P., Companõn, I., Coelho, H., Diniz, A., Jiménez-Barbero, J., Peregrina, J. M., Clausen, H., Corzana, F., Marcelo, F., Jiménez-Osés, G., Gerken, T. A. & Hurtado-Guerrero, R., 1 Dec 2017, In : Nature Communications. 8, 1, 1959.

Research output: Contribution to journalArticle

13 Citations (Scopus)
2015

Beyond a Fluorescent Probe: Inhibition of Cell Division Protein FtsZ by mant-GTP Elucidated by NMR and Biochemical Approaches

Huecas, S., Marcelo, F., Perona, A., Ruiz-Ávila, L. B., Morreale, A., Canada, F. J., Jiménez-Barbero, J. & Andreu, J. M., 16 Oct 2015, In : ACS Chemical Biology. 10, 10, p. 2382-2392 11 p.

Research output: Contribution to journalArticle

6 Citations (Scopus)

D - And L -Mannose-Containing glyco-Oligoamides Show Distinct Recognition Properties When Interacting with DNA

Blázquez-Sánchez, M. T., Marcelo, F., Fernández-Alonso, M. D. C., Del Villar-Guerra, R., Samadi, A., Cañada, F. J., Jiménez-Barbero, J. & Vicent, C., 1 Oct 2015, In : European Journal of Organic Chemistry. 2015, 28, p. 6180-6193 14 p.

Research output: Contribution to journalArticle

8 Citations (Scopus)

Influence of polar side chains modifications on the dual enkephalinase inhibitory activity and conformation of human opiorphin, a pain perception related peptide

Rosa, M., Marcelo, F., Calle, L. P., Rougeot, C., Jiménez-Barbero, J., Arsequell, G. & Valencia, G., 15 Nov 2015, In : Bioorganic and Medicinal Chemistry Letters. 25, 22, p. 5190-5193 4 p.

Research output: Contribution to journalArticle

1 Citation (Scopus)

The Quest for Anticancer Vaccines: Deciphering the Fine-Epitope Specificity of Cancer-Related Monoclonal Antibodies by Combining Microarray Screening and Saturation Transfer Difference NMR

Coelho, H., Matsushita, T., Artigas, G., Hinou, H., Javier Canada, F., Lo-Man, R., Leclerc, C., Cabrita, E. J., Jimenez-Barbero, J., Nishimura, S-I., Garcia-Martin, F. & Marcelo, F. M. B. M., 7 Oct 2015, In : Journal of the American Chemical Society. 137, 39, p. 12438-12441 4 p.

Research output: Contribution to journalArticle

25 Citations (Scopus)
2014

Cooperative Hydrogen Bonding in Glyco-Oligoamides: DNA Minor Groove Binders in Aqueous Media

Teresa Blazquez-Sanchez, M., Marcelo, F., Carmen Fernandez-Alonso, M., Poveda, A., Jimenez-Barbero, J. & Vicent, C., 22 Dec 2014, In : Chemistry-A European Journal. 20, 52, p. 17640-17652 13 p.

Research output: Contribution to journalArticle

7 Citations (Scopus)

Delineating binding modes of Gal/GalNAc and structural elements of the molecular recognition of tumor-associated mucin glycopeptides by the human macrophage galactose-type lectin

Marcelo, F., Garcia-Martin, F., Matsushita, T., Sardinha, J., Coelho, H., Oude-Vrielink, A., Koller, C., André, S., Cabrita, E. J., Gabius, H. J., Nishimura, S. I., Jiménez-Barbero, J. & Cañada, F. J., 12 Jan 2014, In : Chemistry - A European Journal. 20, 49, p. 16147-16155 9 p.

Research output: Contribution to journalArticle

31 Citations (Scopus)

Exploiting the Therapeutic Potential of 8-beta-D-Glucopyranosylgenistein: Synthesis, Antidiabetic Activity, and Molecular Interaction with Islet Amyloid Polypeptide and Amyloid beta-Peptide (1-42)

Jesus, A. R., Dias, C., Matos, A. M., de Almeida, R. F. M., Viana, A. S., Marcelo, F. M. B. M., Ribeiro, R. T., Macedo, M. P., Airoldi, C., Nicotra, F., Martins, A., Cabrita, E. J., Jimenez-Barbere, J. & Rauter, A. P., 27 Nov 2014, In : Journal Of Medicinal Chemistry. 57, 22, p. 9463-9472 10 p.

Research output: Contribution to journalArticle

24 Citations (Scopus)
2013

Diametrically opposed carbenes on an α-cyclodextrin: Synthesis, characterization of organometallic complexes and Suzuki-Miyaura coupling in ethanol and in water

Guitet, M., Marcelo, F., De Beaumais, S. A., Zhang, Y., Jiménez-Barbero, J., Tilloy, S., Monflier, E., Ménand, M. & Sollogoub, M., 1 Jun 2013, In : European Journal of Organic Chemistry. 18, p. 3691-3699 9 p.

Research output: Contribution to journalArticle

31 Citations (Scopus)

Interactions of bacterial cell division protein FtsZ with C8-substituted guanine nucleotide inhibitors. A combined NMR, biochemical and molecular modeling perspective

Marcelo, F., Huecas, S., Ruiz-Ávila, L. B., Cañada, F. J., Perona, A., Poveda, A., Martín-Santamaría, S., Morreale, A., Jiménez-Barbero, J. & Andreu, J. M., 6 Nov 2013, In : Journal of the American Chemical Society. 135, 44, p. 16418-16428 11 p.

Research output: Contribution to journalArticle

26 Citations (Scopus)

Molecular recognition of rosmarinic acid from Salvia sclareoides extracts by acetylcholinesterase: A new binding site detected by NMR spectroscopy

Marcelo, F., Dias, C., Martins, A., Madeira, P. J., Jorge, T., Florêncio, M. H., Cañada, F. J., Cabrita, E. J., Jiménez-Barbero, J. & Rauter, A. P., 17 May 2013, In : Chemistry - A European Journal. 19, 21, p. 6641-6649 9 p.

Research output: Contribution to journalArticle

24 Citations (Scopus)

NHC-Capped Cyclodextrins (ICyDs): Insulated Metal Complexes, Commutable Multicoordination Sphere, and Cavity-Dependent Catalysis

Guitet, M., Zhang, P., Marcelo, F. M. B. M., Tugny, C., Jimenez-Barbere, J., Buriez, O., Amatore, C., Mouriès-Mansuy, V., Goddard, J-P., Fensterbank, L., Zhang, Y., Roland, S., Ménand, M. & Sollogoub, M., 3 Jun 2013, In : Angewandte Chemie-International Edition. 52, 28, p. 7213-7218

Research output: Contribution to journalArticle

Open Access
81 Citations (Scopus)
2012

α-N-Linked glycopeptides: Conformational analysis and bioactivity as lectin ligands

Marcelo, F., Cañada, F. J., André, S., Colombo, C., Doro, F., Gabius, H. J., Bernardi, A. & Jiménez-Barbero, J., 14 Aug 2012, In : Organic and Biomolecular Chemistry. 10, 30, p. 5916-5923 8 p.

Research output: Contribution to journalArticle

7 Citations (Scopus)