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Research Output at NOVA 2002 2019

  • 384 Citations
  • 12 h-Index
  • 34 Article
2019

Structure of hierridin c, synthesis of hierridins b and c, and evidence for prevalent alkylresorcinol biosynthesis in picocyanobacteria

Margarida Sofia, C., Ivo E., S-D., Raquel, C-B., Hugo, S., Roberta C., R. D. C., Silva, A. M. S., Maria Paula Cruz, S., Maria João, A., Martins, R., Domingues, V. F., Nogueira, F., Vera, C., Vasconcelos, V. & Pedro Nuno, L., 22 Feb 2019, In : Journal Of Natural Products. Vol. 82, n.º 2, p. 393-402 9 p.

Research output: Contribution to journalArticle

Prochlorococcus
Synechococcus
Bacterial Genomes
Halogenation
Biosynthesis
2018

Clinical, laboratorial and immunological aspects of severe malaria in children from Guinea-Bissau

Janine, D., Anaxore, C., Daniela, P-C., Varandas, L., Nogueira, F. & Silva, MS., 21 Apr 2018, In : Acta Tropica. Vol. 185, p. 46-51 6 p.

Research output: Contribution to journalArticle

Guinea-Bissau
Malaria
Plasmodium falciparum
Immunodominant Epitopes
Immunoblotting

In vitro antiplasmodial activity, pharmacokinetic profiles and interference in isoprenoid pathway of 2-aniline-3-hydroxy-1.4-naphthoquinone derivatives

Valeska Santana, D. S. P., Flávio, D. S. E., Lis Tavares Coelho, L., Nogueira, F., Jonas I.N., O., Umberto L., F., Eudenílson Lins De, A., Alejandro Miguel, K. & De Andrade-Neto, V. F., 19 Dec 2018, In : Malaria Journal. Vol. 17, n.º 1, p. 482-493 11 p., 482.

Research output: Contribution to journalArticle

Open Access
Naphthoquinones
Terpenes
Pharmacokinetics
Chloroquine
Antimalarials
5 Citations (Scopus)

New endoperoxides highly active in vivo and in vitro against artemisinin-resistant Plasmodium falciparum

Lobo, L., Cabral, L. I. L., Sena, M. I., Guerreiro, B., Rodrigues, A. S., De Andrade-Neto, V. F., Cristiano, M. L. S. & Nogueira, F., 3 Apr 2018, In : Malaria Journal. 17, 1, 145.

Research output: Contribution to journalArticle

Open Access
Plasmodium falciparum
Antimalarials
Plasmodium berghei
Parasitemia
Tetraoxanes
2017
4 Citations (Scopus)

On the ordeal of quinolone preparation via cyclisation of aryl-enamines; Synthesis and structure of ethyl 6-methyl-7-iodo-4-(3-iodo-4-methylphenoxy)-quinoline-3-carboxylate

Horta, P., Henriques, M. S. C., Brás, E. M., Murtinheira, F., Nogueira, F., O'Neill, P. M., Paixaõ, J. A., Fausto, R. & Cristiano, M. L. S., 27 Jun 2017, In : Pure and Applied Chemistry. 89, 6, p. 765-780 16 p.

Research output: Contribution to journalArticle

Cyclization
Quinolones
Esters
Enzymes
quinoline
2016
1 Citation (Scopus)
1 Downloads (Pure)

Highly active ozonides selected against drug resistant malaria

Lobo, L., de Sousa, B., Cabral, L. I. L., Cristiano, M. L. S. & Nogueira, F., 1 Jul 2016, In : Memorias do Instituto Oswaldo Cruz. 111, 7, p. 450-453 4 p.

Research output: Contribution to journalArticle

Open Access
File
dihydroartemisinin
Plasmodium falciparum
Malaria
Plasmodium chabaudi
Mefloquine
12 Citations (Scopus)

Primaquine-based ionic liquids as a novel class of antimalarial hits

Ferraz, R., Noronha, J., Murtinheira, F., Nogueira, F., Machado, M., Prudêncio, M., Parapini, S., D'Alessandro, S., Teixeira, C., Gomes, A., Prudêncio, C. & Gomes, P., 2016, In : RCS Advances. 6, 61, p. 56134-56138 5 p.

Research output: Contribution to journalArticle

Primaquine
Ionic Liquids
Antimalarials
Ionic liquids
Pharmaceutical Preparations
9 Downloads (Pure)

Whole-cell SYBR Green I assay for antimalarial activity assessment

Machado, M., Murtinheira, F., Lobo, E. & Nogueira, F., 2016, In : Annals of Clinical and Medical Microbiology. 2

Research output: Contribution to journalArticle

Open Access
File
Antimalarials
Centrifugation
Detergents
Nucleic Acids
Malaria
2015
10 Citations (Scopus)

Exploring the 3-piperidin-4-yl-1H-indole scaffold as a novel antimalarial chemotype

Santos, S. A., Lukens, A. K., Coelho, L., Nogueira, F., Wirth, D. F., Mazitschek, R., Moreira, R. & Paulo, A., 18 Sep 2015, In : European Journal of Medicinal Chemistry. 102, p. 320-333 14 p., 8031.

Research output: Contribution to journalArticle

Antimalarials
Scaffolds
Indoles
Chloroquine
Plasmodium falciparum
9 Citations (Scopus)

N10,N11-di-alkylamine indolo[3,2-b]quinolines as hemozoin inhibitors: Design, synthesis and antiplasmodial activity

Figueiras, M., Coelho, L., Wicht, K. J., Santos, S. A., Lavrado, J., Gut, J., Rosenthal, P. J., Nogueira, F., Egan, T. J., Moreira, R. & Paulo, A., 1 Apr 2015, In : Bioorganic & Medicinal Chemistry. 23, 7, p. 1530-1539 10 p.

Research output: Contribution to journalArticle

Quinolines
Chloroquine
Antimalarials
Growth Inhibitors
Hemin
11 Citations (Scopus)

N-Cinnamoylation of Antimalarial Classics: Effects of Using Acyl Groups Other than Cinnamoyl toward Dual-Stage Antimalarials

Gomes, A., Machado, M., Lobo, L., Nogueira, F., Prudêncio, M., Teixeira, C. & Gomes, P., 1 Aug 2015, In : Chemmedchem. 10, 8, p. 1344-1349 6 p.

Research output: Contribution to journalArticle

Antimalarials
Liver
Blood
Plasmodium berghei
Plasmodium falciparum
18 Citations (Scopus)
2 Downloads (Pure)

Polymorphisms in Plasmodium falciparum K13-propeller in angola and mozambique after the introduction of the ACTs

Escobar, C., Pateira, S., Lobo, E., Lobo, L., Teodosio, R., Dias, F., Fernandes, N., Arez, A. P., Varandas, L. & Nogueira, F., 19 Mar 2015, In : PlosOne. 10, 3, e0119215.

Research output: Contribution to journalArticle

Open Access
File
Angola
Mozambique
Functional analysis
Plasmodium falciparum
Public health
11 Citations (Scopus)

Quinolone-Hydroxyquinoline Tautomerism in Quinolone 3-Esters. Preserving the 4-Oxoquinoline Structure To Retain Antimalarial Activity

Horta, P., Kuş, N., Henriques, M. S. C., Paixão, J. A., Coelho, L., Nogueira, F., O'Neill, P. M., Fausto, R. & Cristiano, M. L. S., 9 Nov 2015, In : Journal of Organic Chemistry. 80, 24, p. 12244-12257 14 p.

Research output: Contribution to journalArticle

Hydroxyquinolines
4-Quinolones
Quinolones
Antimalarials
Esters
10 Citations (Scopus)

Synthesis and antimalarial evaluation of prodrugs of novel fosmidomycin analogues

Phillips, A. M. M. M. F., Nogueira, F., Murtinheira, F. & Barros, M. T., 15 May 2015, In : Bioorganic & Medicinal Chemistry Letters. 25, 10, p. 2112-2116 5 p.

Research output: Contribution to journalArticle

2014
Open Access
Malaria
Portugal
Angola
Research
Vivax Malaria
17 Citations (Scopus)

N-cinnamoylation of antimalarial classics: Quinacrine analogues with decreased toxicity and dual-stage activity

Gomes, A., Prez, B., Albuquerque, I., Machado, M., Prudpncio, M., Nogueira, F., Teixeira, C. & Gomes, P., 2014, In : Chemmedchem. 9, 2, p. 305-310 6 p.

Research output: Contribution to journalArticle

Quinacrine
Antimalarials
Toxicity
Inhibitory Concentration 50
Chemotherapy
41 Citations (Scopus)

Plasmodium vivax chloroquine resistance and anemia in the western brazilian amazon

Marques, M. M., Costa, M. R. F., Santana Filho, F. S., Vieira, J. L. F., Nascimento, M. T. S., Brasil, L. W., Nogueira, F., Silveira, H., Reyes-Lecca, R. C., Monteiro, W. M., Lacerda, M. V. G. & Alecrim, M. G. C., Jan 2014, In : Antimicrobial Agents and Chemotherapy. 58, 1, p. 342-347 6 p.

Research output: Contribution to journalArticle

Plasmodium vivax
Chloroquine
Anemia
Parasitemia
Malaria
18 Citations (Scopus)

Prevalence of pfmdr1 alleles associated with artemether-lumefantrine tolerance/resistance in Maputo before and after the implementation of artemisinin-based combination therapy

Lobo, E., De Sousa, B., Rosa, S., Figueiredo, P., Lobo, L., Pateira, S., Fernandes, N. & Nogueira, F., 6 Aug 2014, In : Malaria Journal. 13, 1, 300.

Research output: Contribution to journalArticle

Alleles
Haplotypes
Codon
Mozambique
Therapeutics
29 Citations (Scopus)

Probing the aurone scaffold against Plasmodium falciparum: Design, synthesis and antimalarial activity

Carrasco, M. P., Newton, A. S., Gonçalves, L., Góis, A., Machado, M., Gut, J., Nogueira, F., Hänscheid, T., Guedes, R. C., Dos Santos, D. J. V. A., Rosenthal, P. J. & Moreira, R., 10 Jun 2014, In : European Journal of Medicinal Chemistry. 80, p. 523-534 12 p.

Research output: Contribution to journalArticle

Antimalarials
Plasmodium falciparum
Scaffolds
Palladium
Vacuoles
2013

Differences between synthetic β-haematin and native hemozoin crystals.

Nogueira, M. D. F. C., 1 Jan 2013, In : Microscopy and Microanalysis. 19, Suppl. 4, p. 49-50

Research output: Contribution to journalArticle

10 Citations (Scopus)

Immunoproteomic analysis of Plasmodium falciparum antigens using sera from patients with clinical history of imported malaria.

Costa, R. M. ., Nogueira, M. D. F. C., De Sousa, K. P. ., Vitorino, R. . & Silva, M., 1 Jan 2013, In : Malaria Journal. 12, NA, p. 100

Research output: Contribution to journalArticle

Open Access
23 Citations (Scopus)

In vitro chloroquine resistance for Plasmodium vivax isolates from the Western Brazilian Amazon

Chehuan, Y. F., Costa, M. R., Costa, J. S., Alecrim, M. G., Nogueira, F., Silveira, H., Brasil, L. W., Melo, G. C., Monteiro, W. M. & Lacerda, M. V., 11 Jul 2013, In : Malaria Journal. 12, 1, 226.

Research output: Contribution to journalArticle

Plasmodium vivax
Chloroquine
Mefloquine
L-Lactate Dehydrogenase
Vivax Malaria
2012
28 Citations (Scopus)

Novel potent metallocenes against liver stage malaria.

Nogueira, M. D. F. C. & Rosário, V. E. D., 1 Jan 2012, In : Antimicrobial Agents and Chemotherapy. 56, 3, p. 1564-1570

Research output: Contribution to journalArticle

Open Access
2011
10 Citations (Scopus)

SLC40A1 Q248H allele frequencies and associated SLC40A1 haplotypes in three West African population samples.

Albuquerque, D., Manco, L., Loua, KM., Arez, A. P. M. D. R., Trovoada, MJ., Relvas, L., Millimono, TS., Rath, SL., Ferreira, D., Nogueira, M. D. F. C., Varandas, L. M., Alvarez, M. & Ribeiro, ML., 1 Jan 2011, In : Annals Of Human Biology. 38, 3, p. 378-381

Research output: Contribution to journalArticle

Open Access
2010
20 Citations (Scopus)

Early transcriptional response to chloroquine of the Plasmodium falciparum antioxidant defence in sensitive and resistant clones

Nogueira, M. D. F. C., Diez, A., Radfar, A., Pérez-Benavente, S., Rosário, V. E. D., Puyet, A. & Bautista, JM., 1 Jan 2010, In : Acta Tropica. 114, 2, p. 109-115

Research output: Contribution to journalArticle

Open Access
2009
33 Citations (Scopus)

Imidazoquines as Antimalarial and Antipneumocystis Agents

Rosário, V. E. D. & Nogueira, M. D. F. C., 1 Jan 2009, In : Journal Of Medicinal Chemistry. 52, 23, p. 7800-7807

Research output: Contribution to journalArticle

Open Access

Is the expression of genes encoding enzymes of glutathione (GSH) metabolism involved in chloroquine resistance in Plasmodium chabaudi parasites?

Ferreira, I. D., Nogueira, F., Borges, S. T., do Rosário, V. E. & Cravo, P., Jul 2004, In : Molecular And Biochemical Parasitology. 136, 1, p. 43-50 8 p.

Research output: Contribution to journalArticle

Plasmodium chabaudi
Chloroquine
Glutathione
Parasites
Gene Expression
2003
39 Citations (Scopus)

Detection of atovaquone and Malarone™ resistance conferring mutations in Plasmodium falciparum cytochrome b gene (cytb)

Gil, J. P., Nogueira, F., Strömberg-Nörklit, J., Lindberg, J., Carrolo, M., Casimiro, C., Lopes, D., Arez, A. P., Cravo, P. V. & Rosário, V. E., Apr 2003, In : Molecular and Cellular Probes. 17, 2-3, p. 85-89 5 p.

Research output: Contribution to journalArticle

Atovaquone
Cytochromes b
Plasmodium falciparum
Restriction Fragment Length Polymorphisms
Mutation
2002
3 Downloads (Pure)

Molecular characterisation of drug-resistant Plasmodium falciparum from Thailand

Lopes, D., Rungsihirunrat, K., Nogueira, F., Seugorn, A., Gil, J. P., do Rosário, V. E. & Cravo, P., 14 Oct 2002, In : Malaria Journal. 1, p. 12

Research output: Contribution to journalArticle

Open Access
File
Chloroquine
Thailand
Plasmodium falciparum
Mefloquine
Amodiaquine